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4 - The Connection between Cellular Senescence and Age-Related Diseases

from Part I - Biomedical Aspects

Published online by Cambridge University Press:  10 January 2019

By
Claire Falandry
Edited by
Rocío Fernández-Ballesteros ,
Athanase Benetos  and
Jean-Marie Robine
Rocío Fernández-Ballesteros
Affiliation:
Universidad Autónoma de Madrid
Athanase Benetos
Affiliation:
Université de Lorraine and Institut national de la santé et de la recherche médicale (INSERM) Nancy
Jean-Marie Robine
Affiliation:
INSERM
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Summary

Age is associated with a progressive decline in the functional reserve of multiple organ systems and, at the molecular and cellular level, with the accumulation of mutations. Cumulative evidence has demonstrated that senescence contributes both to tissue exhaustion as well as diseases associated with aging. This article seeks at answering to the simple following questions, on the basis on current knowledge and recent findings coming from basic and translational research: (i) why do somatic cells have to senesce?; (ii) how to define cell senescence(s)?; (iii) how senescence is activated?; (iv) what are the phenotypic changes are induced by senescence?; (v) what are the relationships between senescence and the longevity pathways? and (vi) what are the relationships between senescence and age-related diseases? In this last section, a special attention is paid to the more frequent age-related diseases: osteoporosis, neurodegenerative diseases, atherosclerosis, type 2 diabetes, cataract, respiratory diseases and cancer.
Type
Chapter
Information
The Cambridge Handbook of Successful Aging , pp. 41 - 52
Publisher: Cambridge University Press
Print publication year: 2019

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