As the population ages, the number of older people with frailty is expected to increase worldwide with consequent rising of expenditures for healthcare and long-term care. Effective methods for preventing or delaying the onset of frailty are urgently required. Frailty is a common and important geriatric condition characterized by age-associated declines in multiple physiological mechanisms, leading to increased vulnerability to stressors and higher risk for adverse health outcomes. Significant advancements have been made in the understanding of the frailty pathophysiological background. Chronic inflammation is likely a key mechanism contributing to frailty both directly as well as indirectly, by affecting a wide spectrum of systems (e.g., the musculoskeletal, endocrine, and hematologic systems). Given its multidimensional nature, preventing frailty requires a comprehensive approach. In this context, raising awareness about healthy lifestyle and improving health education are key interventions for the prevention of frailty. Every effort should be made by healthcare authorities in order to maximize efforts in this field, taking into account the need of balancing priorities, needs, and resources.