Use of biochar (B) and poultry manure (PM) as soil amendments can improve the productivity and sustainability of tropical agriculture. Our fieldwork is the first research on the agronomic use of B and PM for the growth of cocoyam in sandy soil of the humid tropics. In this study, the effects of B, PM and their mixture were investigated on soil properties, mineral and nutrient concentrations, growth, and corm and cormel yields of cocoyam during the 2017 and 2018 cropping seasons. The experiment consisted of 4 × 2 factorial combinations of B (0, 10, 20, and 30 Mg ha−1) and PM (0 and 7.5 Mg ha−1). In both years, the application of B and PM either alone or in combination improved soil physical and chemical properties, plant nutritional status, growth, and corm and cormel yields of cocoyam. The combination of 30 Mg ha−1 B and 7.5 Mg ha−1 PM (B30 + PM7.5) gave the highest corm and cormel yields of cocoyam. Pooled over the 2 years, application of B at 30 Mg ha−1 and PM at 7.5 Mg ha−1 (B30 + PM7.5) significantly increased corm yield of cocoyam by 47 and 66%, respectively, when compared with sole PM at 7.5 Mg ha−1 and B at 30 Mg ha−1. Lowest corm and cormel yields were obtained for the unmanure control. The combination of 30 Mg ha−1 B and 7.5 Mg ha−1 PM is recommended for soil fertility management and cocoyam production in the rainforest agroecology of SW Nigeria.