Hostname: page-component-7c8c6479df-nwzlb Total loading time: 0 Render date: 2024-03-19T03:19:23.400Z Has data issue: false hasContentIssue false

Intake, status and dietary sources of riboflavin in a representative sample of Irish adults aged 18–90 years

Published online by Cambridge University Press:  06 September 2018

L. Kehoe
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Ireland
J. Walton
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Ireland Dept. Biological Sciences, Cork Institute of Technology, Ireland
S.M. Hopkins
Affiliation:
UCD Institute of Food and Health, University College Dublin, Ireland
B.A. McNulty
Affiliation:
UCD Institute of Food and Health, University College Dublin, Ireland
A.P. Nugent
Affiliation:
UCD Institute of Food and Health, University College Dublin, Ireland Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, Northern Ireland
H. McNulty
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
M. Ward
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
A. Flynn
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Ireland
Rights & Permissions [Opens in a new window]

Abstract

Type
Abstract
Copyright
Copyright © The Authors 2018 

Riboflavin is a water soluble B-vitamin which, in its coenzymatic forms flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) is required for numerous oxidation/reduction reactions and plays an integral role in the metabolism of other B-vitamins and the related metabolite homocysteine. The objective of this study was to estimate the usual intake, prevalance of inadequate intakes, biochemical status and dietary sources of riboflavin in Irish adults using data from the National Adult Nutrition Survey (2008–2010) (www.iuna.net). A 4-day semi-weighed food record was used to collect food and beverage intake data from a representative sample of 1500 Irish adults (18–90 years). Dietary intake data was analysed using WISP© based on UK(1) and Irish(Reference Black, Ireland and Moller2) food compositon tables. Blood samples (n 1126) were collected, processed and analysed using stardard operating procedures. Usual intakes were calculated via the NCI-method(Reference Tooze, Kipnis and Buckman3) using SAS© Enterprise Guide. The estimated average requirement (EAR) of 1·3 mg/d (for adults ≥18 years) established by the European Food Safety Authority(4) was used as a cut-off to assess the prevalence of inadequate intakes (excluding energy-underreporters). Determination of riboflavin biomarker status was by erythrocyte glutathione reductase activation coefficient (EGRac), calculated as the ratio of flavin-dependent glutathione reductase activity before and after in vitro reactivation with its prosthetic group FAD, with a cut-off value of >1·3 generally used to indicate low/deficient status(Reference McAuley, McNulty and Huges5).

Table 1. Prevalence of low/deficient riboflavin intakes/biomarker status and key dietary sources of riboflavin

The mean daily intake (MDI) of riboflavin from the total diet was 2·5 mg/d (ranging from 2·2–3·1 mg/d range across population groups) with 18% having inadequate intakes (10–26% range across ages). Blood sample analysis showed that 61% of adults exceeded the EGRac cut-off of 1·3. The key dietary sources of riboflavin in the population were milks (20–24% across ages), ‘meat & meat products’ (14–18%), ready-to-eat breakfast cereals (6–14%), ‘beverages’ (7–12%) and ‘bread & rolls’ (4–7%). Nutritional supplements provided 4–10% of intakes. Results were similar when analysis was restricted to those with biochemical data only (n 1126). These findings show that a significant proportion of Irish adults have low dietary intakes of riboflavin. Even higher proportions have evidence of deficient/low biomarker status; however, the functional significance of an EGRac value >1·3 is unclear and requires further research.

This publication has emanated from research supported in part by a Grant from Science Foundation Ireland (Grant number 16/ERA-HDHL/3357) within the programme of ERA-HDHL – Biomarkers for Nutrition & Health. (www.healthydietforhealthylife.eu/index.php/64-open-calls/311-derive). The National Adult Nutrition Survey was funded by the Irish Department of Agriculture, Fisheries & Food under the Food for Health Research Initiative (2007–2012).

References

1.Food Standards Agency (2002) The Composition of Foods. Cambridge: Royal Society of ChemistryGoogle Scholar
2.Black, LJ, Ireland, J, Moller, A et al. (2011) J Food Compost Anal 24(7), 10171023.Google Scholar
3.Tooze, JA, Kipnis, V, Buckman, DW et al. (2010) Stat Med 29(27), 28572868.Google Scholar
4.EFSA (2017) EFSA J 15(8), 4919.Google Scholar
5.McAuley, E, McNulty, H, Huges, C et al. (2016) Proc Nutr Soc 75(3), 405414.Google Scholar
Figure 0

Table 1. Prevalence of low/deficient riboflavin intakes/biomarker status and key dietary sources of riboflavin