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Naturally acquired resistance to experimental infections of Schistosoma mansoni in the rhesus monkey (Macaca mulatta)

Published online by Cambridge University Press:  10 June 2015

S. R. Smithers  and
R. J. Terry
S. R. Smithers
Affiliation:
National Institute for Medical Research, London, N. W. 7 and S.E. Essex College of Technology, Dagenham, Essex
R. J. Terry
Affiliation:
National Institute for Medical Research, London, N. W. 7 and S.E. Essex College of Technology, Dagenham, Essex
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Extract

In recent years there has been a steadily growing interest in the immunology of schistosomiasis. Much work has been carried out using a variety of experimental hosts and many attempts have been made to vaccinate these hosts against schistosomes, both by exposing them to irradiated cercariae and by injecting them with various antigens derived from the parasites. These attempts have been attended by varying degrees of success. The ultimate object of much of this work has been its possible application to the disease in man. We believe, however, that work of this kind cannot really be profitably undertaken unless there already exists a sound understanding of the basic host-parasite relations between the schistosomes and their hosts. This knowledge is essential in order to decide whether a finding in one host is likely to be applicable in others. With this idea in mind, we report here our findings on naturally acquired resistance to Schistosoma mansoni in the rhesus monkey.

Type
Research Article
Information
Parasitology , Volume 55 , Issue 4 , November 1965 , pp. 701 - 710
Copyright
Copyright © Cambridge University Press 1965

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References

REFERENCES

Evans, A. S. & Stirewalt, M. A. (1951). Variations in infectivity of cereariae of Schistosoma mansoni. Expl Parasit. 1, 19–33.CrossRefGoogle Scholar
Hunter, G. W. III, Crandall, R. B., Zickafoose, D. E. & Purvis, Q. B. (1962). Studies on sehistosomiasis. XVIII. Some factors affecting resistance to Schistosoma mansoni infections in albino mice. Am. J. trop. Med. Hyg. 11, 17–24.CrossRefGoogle Scholar
Hunter, G. W. III, Hodges, E. P., Jahnes, W. G., Diamond, L. S. & Ingaills, J. W. (1948). Studies on schistosomiasis. II. Summary of further studies on methods of recovering eggs of S. japonicum from stools. Bull. U.S. Army Med. Dep. 8, 128–31.Google ScholarPubMed
Hsü, S. Y. Li & Hsü, H. F. (1963). Further studies on rhesus monkeys immunized against Schistosoma japonicum by administration of cercariae of the Formosan strain. Z. Tropenmed. Parasit. 14, 506–11.Google Scholar
Lichtenberg, F. von, Sadun, E. H. & Bruce, J. I. (1963). Host response to eggs of Schistosoma mansoni. III. The role of eggs in resistance. J. infect. Dis. 113, 113–22.CrossRefGoogle Scholar
Naimark, D. H., Benenson, A. S., Oliver-Gonzalez, J., McMullen, D. B. & Ritchie, L. S. (1960). Studies of schistosomiasis in primates: observations on acquired resistance (progress report). Am. J. trop. Med. Hyg. 9, 430–5.CrossRefGoogle ScholarPubMed
Newsome, J. (1956). Problems of fluke immunity; with special reference to schistosomiasis. Trans. R. Soc. trop. Med. Hyg. 50, 258–74.CrossRefGoogle ScholarPubMed
Ritchie, L. S., Knight, W. B. & Oliver-Gonzalez, J. (1964). Biology of Schistosoma mansoni in the green monkey (Cercopithecus) occurring on St Kitts Island (Br. W. Indies). J. Parasit. 50, (3), Sect. 2, 21–22 (abstract).Google Scholar
Sadun, E. H. & Bruce, J. I. (1964). Resistance induced in rats by previous exposure to and by vaccination with fresh homogenates of Schistosoma mansoni. Expl Parasit. 15, 32–43.CrossRefGoogle Scholar
Sadun, E. H., Bruce, J. I. & Macomber, P. B. (1964). Parasitologic, pathologic and serologic reactions to Schistosoma mansoni in monkeys exposed to irradiated cercariae. Am. J. trop. Med. Hyg. 13, 548–57.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965 a). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology, 55, 695.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965 b). Acquired resistance to experimental infections of Schistosoma mansoni in the albino rat. Parasitology, 55, 711.CrossRefGoogle ScholarPubMed
Vogel, H. & Minning, W. (1953). Über die erworbene Resistenz von Macacus rhesus gegenüber Schistosoma japonicum. Z. Tropenmed. Parasit. 4, 418–505.Google ScholarPubMed