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Neurocognitive Development and Behavioral Outcome of 2-Year-Old Children with Univentricular Heart

Published online by Cambridge University Press:  13 October 2011

Riina Puosi ,
Marit Korkman ,
Anne Sarajuuri ,
Eero Jokinen ,
Leena Mildh ,
Ilkka Mattila  and
Tuula Lönnqvist
Riina Puosi*
Affiliation:
Division of Child Neurology, Helsinki University Central Hospital, Helsinki, Finland
Marit Korkman
Affiliation:
University of Helsinki, Helsinki, Finland
Anne Sarajuuri
Affiliation:
Division of Child Neurology, Helsinki University Central Hospital, Helsinki, Finland
Eero Jokinen
Affiliation:
Division of Pediatrics, Helsinki University Central Hospital, Helsinki, Finland
Leena Mildh
Affiliation:
Department of Anesthesia and Intensive Care, Helsinki University Central Hospital, Helsinki, Finland
Ilkka Mattila
Affiliation:
Division of Pediatric Surgery, Helsinki University Central Hospital, Helsinki, Finland
Tuula Lönnqvist
Affiliation:
Division of Child Neurology, Helsinki University Central Hospital, Helsinki, Finland
*
Correspondence and reprint requests to: Riina Puosi, Division of Child Neurology, Helsinki University Central Hospital, P.O. Box 280, 00029 HUS, Finland. E-mail: riina.puosi@hus.fi
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Abstract

Recent advances in the treatment of children with severe congenital heart defects, such as hypoplastic left heart syndrome (HLHS) and other forms of univentricular heart (UVH), have significantly improved their survival rates. However, these children are at risk for various neurodevelopmental deficits. The aim of the present study was to assess cognitive development, expressive language, and behavior in 30-month-old children with univentricular heart. The participants were 22 children with HLHS, 14 with UVH, and 41 healthy control subjects. The Bayley Scales of Infant Development II, MacArthur Communicative Development Inventories, and Child Behavior Checklist were used for assessments. The results revealed that children with HLHS exhibited a significantly lower mean mental development index, more delays in expressive language functions, and more behavioral problems than did the control children. Two children with HLHS (9%) had mental development indexes below 50, indicating significantly delayed performance. The children with UVH differed from the control children with respect to their lower mean mental development index. These findings suggest that at the age of 30 months, neurodevelopmental deficits are especially prevalent in children with HLHS. Thus, early developmental screening, intervention, and neuropsychological follow-up until school age is recommended particularly for the children with HLHS. (JINS, 2011, 17, 1094–1103)

Keywords

BehaviorCongenital heart defectExpressive languageHypoplastic left heart syndromeNeurodevelopmental deficits.
Type
Regular Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 6 , November 2011 , pp. 1094 - 1103
Copyright
Copyright © The International Neuropsychological Society 2011

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