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Obstetric complications in patients with schizophrenia and their unaffected siblings

  • M. Walshe (a1), C. McDonald (a1), M. Taylor (a1), J. Zhao (a1), P. Sham (a1), A. Grech (a1), K. Schulze (a1), E. Bramon (a1) and R.M. Murray (a1)...

Abstract

Objective

We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia.

Methods

The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group.

Results

OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings.

Conclusion

Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes.

Copyright

Corresponding author

*Corresponding author. E-mail address: c.mcdonald@iop.kcl.ac.uk (C. McDonald).

References

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Keywords

Obstetric complications in patients with schizophrenia and their unaffected siblings

  • M. Walshe (a1), C. McDonald (a1), M. Taylor (a1), J. Zhao (a1), P. Sham (a1), A. Grech (a1), K. Schulze (a1), E. Bramon (a1) and R.M. Murray (a1)...

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Obstetric complications in patients with schizophrenia and their unaffected siblings

  • M. Walshe (a1), C. McDonald (a1), M. Taylor (a1), J. Zhao (a1), P. Sham (a1), A. Grech (a1), K. Schulze (a1), E. Bramon (a1) and R.M. Murray (a1)...
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