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Genetic and environmental pathways to suicidal behavior: Reflections of a genetic epidemiologist

Published online by Cambridge University Press:  16 April 2020

K.S. Kendler
K.S. Kendler*
Affiliation:
Room 1-123, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E. Leigh Street, Richmond, VA 23298-0126, VA, USA
*
*Tel.: +804 828 8590; fax: +804 828 1471. E-mail address: kendler@vcu.edu
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Abstract

This paper presents a tentative typology of genetic and environmental pathways to suicidal behavior. Ten pathways are proposed and briefly illustrated: (i) direct effects from psychiatric disorders; (ii) direct effects from personality; (iii) direct effects of early adversity; (iv) direct effects of current adversity; (v) indirect effects of genes on selection into adversity (gene–environment correlation); (vi) interactions between genetic risk and current adversity: gene–environment interaction; (vii) interactions between early and current adversity: environment–environment interaction; (viii) interactions between culture and genes; (ix) dynamic developmental pathways involving causal loops from genes to environment and back again; and (x) gene × environment × development interaction.

Keywords

SuicideGeneticsEnvironment
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 300 - 303
Copyright
Copyright © Elsevier Masson SAS 2010

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