Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-17T21:39:08.920Z Has data issue: false hasContentIssue false
  • English
  • Français

Neurocognitive functions of heavy cannabis using schizophrenia patients

Published online by Cambridge University Press:  15 April 2020

S. Lev-Ran ,
A. Segev ,
Y. Braw  and
Y. Levkovitz
S. Lev-Ran*
Affiliation:
Cognitive and Emotional Laboratory, Shalvata Mental Health Center, POB 94, Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A. Segev
Affiliation:
Cognitive and Emotional Laboratory, Shalvata Mental Health Center, POB 94, Hod-Hasharon, Israel
Y. Braw
Affiliation:
Cognitive and Emotional Laboratory, Shalvata Mental Health Center, POB 94, Hod-Hasharon, Israel Department of Behavioral Sciences, Ariel University Center of Samaria, Ariel, Israel
Y. Levkovitz
Affiliation:
Cognitive and Emotional Laboratory, Shalvata Mental Health Center, POB 94, Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
*
*Corresponding author. Tel.: +972 9 7478644; fax: +972 9 7478643. E-mail address: shauli.levran@gmail.com (S. Lev-Ran).
Get access

Abstract

This current study assessed neurocognitive functioning in a carefully selected sample of schizophrenia patients with and without heavy cannabis use and healthy controls. All subjects were negative for any other substance use. Schizophrenia subjects had impaired neurocognitive functions across a wide range of tasks compared to healthy controls. Cannabis using schizophrenia patients had focused impairments on tasks of attention, and the findings suggest an impulsive pattern of response among these patients.

Keywords

SchizophreniaCannabisNeurocognitive
Type
Short communications
Information
European Psychiatry , Volume 27 , Issue 5 , July 2012 , pp. 365 - 368
Copyright
Copyright © Elsevier Masson SAS 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addington, J., Addington, D.Substance abuse and cognitive functioning in schizophrenia. J Psychiatry Neurosci. 22 2: 1997 99–104.Google Scholar
Braw, Y., Bloch, Y., Mendelovich, S., Ratzoni, G., Gal, G., Harari, H.et al.Cognition in young schizophrenia outpatients: comparison of first-episode with multiepisode patients. Schizophr Bull. 34 3: 2008 544–554.CrossRefGoogle ScholarPubMed
Carey, K.B., Carey, M.P., Simons, J.S.Correlates of substance use disorder among psychiatric outpatients: focus on cognition, social role functioning, and psychiatric status. J Nerv Ment Dis. 191 5: 2003 300–308.CrossRefGoogle ScholarPubMed
Caspari, D.Cannabis and schizophrenia: results of a follow-up study. Eur Arch Psychiatry Clin Neurosci. 249 1: 1999 45–49.CrossRefGoogle ScholarPubMed
Cheniaux, E., Landeira-Fernandez, J., Lessa Telles, L., Lessa, J.L., Dias, A., Duncan, T.et al.Does schizoaffective disorder really exist? A systematic review of the studies that compared schizoaffective disorder with schizophrenia or mood disorders. J Affect Disord. 106 3: 2008 209–217.CrossRefGoogle ScholarPubMed
Degenhardt, L., Tennant, C., Gilmour, S., Schofield, D., Nash, L., Hall, W.et al.The temporal dynamics of relationships between cannabis, psychosis and depression among young adults with psychotic disorders: findings from a 10-month prospective study. Psychol Med. 37 7: 2007 927–934.CrossRefGoogle ScholarPubMed
DeRosse, P., Kaplan, A., Burdick, K.E., Lencz, T., Malhotra, A.K.Cannabis use disorders in schizophrenia: effects on cognition and symptoms. Schizophr Res. 120 1–3: 2010 95–100 [Epub ahead of print].CrossRefGoogle ScholarPubMed
Dervaux, A., Goldberger, C., Gourion, D., Bourdel, M.C., Laqueille, X., Loo, H.et al.Impulsivity and sensation seeking in cannabis abusing patients with schizophrenia. Schizophr Res. 123 2–3: 2010 278–280[Epub ahead of print].CrossRefGoogle ScholarPubMed
Dowson, J.H., Blackwell, A.D., Turner, D.C., Harvey, E., Malhotra, T., Robbins, T.W.et al.Questionnaire ratings of attention-deficit/hyperactivity disorder (ADHD) in adults are associated with spatial working memory. Eur Psychiatry. 22 4: 2007 256–263.CrossRefGoogle ScholarPubMed
D'Souza, D.C., Abi-Saab, W.M., Madonick, S., Forselius-Bielen, K., Doersch, A., Braley, G.et al.Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biol Psychiatry. 57 6: 2005 594–608.CrossRefGoogle ScholarPubMed
Grech, A., Van Os, J., Jones, P.B., Lewis, S.W., Murray, R.M.Cannabis use and outcome of recent onset psychosis. Eur Psychiatry. 20 4: 2005 349–353.CrossRefGoogle ScholarPubMed
Hides, L., Dawe, S., Kavanagh, D.J., Young, R.M.Psychotic symptom and cannabis relapse in recent-onset psychosis. Prospective study. Br J Psychiatry. 2006; 189: 137–143.CrossRefGoogle ScholarPubMed
Jockers-Scherubl, M.C., Wolf, T., Radzei, N., Schlattmann, P., Rentzsch, J., Gomez-Carrillo de Castro, A.et al.Cannabis induces different cognitive changes in schizophrenic patients and in healthy controls. Prog Neuropsychopharmacol Biol Psychiatry. 31 5: 2007 1054–1063.CrossRefGoogle ScholarPubMed
Koskinen, J., Lohonen, J., Koponen, H., Isohanni, M., Miettunen, J.Rate of cannabis use disorders in clinical samples of patients with schizophrenia: a meta-analysis. Schizophr Bull. 36 6: 2010 1115–1130.CrossRefGoogle ScholarPubMed
Moore, T.H., Zammit, S., Lingford-Hughes, A., Barnes, T.R., Jones, P.B., Burke, M.et al.Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet. 370 9584: 2007 319–328.CrossRefGoogle ScholarPubMed
Mueser, K.T., Drake, R.E., Wallach, M.A.Dual diagnosis: a review of etiological theories. Addict Behav. 23 6: 1998 717–734.CrossRefGoogle ScholarPubMed
Ramaekers, J.G., Kauert, G., Theunissen, E.L., Toennes, S.W., Moeller, M.R.Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. J Psychopharmacol. 23 3: 2009 266–277.CrossRefGoogle ScholarPubMed
Regier, D.A., Farmer, M.E., Rae, D.S., Locke, B.Z., Keith, S.J., Judd, L.L.et al.Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic catchment area (ECA) Study. JAMA. 264 19: 1990 2511–2518.CrossRefGoogle ScholarPubMed
Ruiz-Veguilla, M., Gurpegui, M., Barrigon, M.L., Ferrin, M., Marin, E., Rubio, J.L.et al.Fewer neurological soft signs among first episode psychosis patients with heavy cannabis use. Schizophr Res. 107 2–3: 2009 158–164.CrossRefGoogle ScholarPubMed
Solowij, N., Stephens, R.S., Roffman, R.A., Babor, T., Kadden, R., Miller, M.et al.Cognitive functioning of long-term heavy cannabis users seeking treatment. JAMA. 287 9: 2002 1123–1131.CrossRefGoogle ScholarPubMed
Yucel, M., Solowij, N., Respondek, C., Whittle, S., Fornito, A., Pantelis, C.et al.Regional brain abnormalities associated with long-term heavy cannabis use. Arch Gen Psychiatry. 65 6: 2008 694–701.CrossRefGoogle ScholarPubMed
Yucel, M., Bora, E., Lubman, D.I., Solowij, N., Brewer, W.J., Cotton, S.M.et al.The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample. Schizophr Bull. 2010 10.1093/schbul/sbp079 [Published online: 25 July 2010].Google Scholar
Zuardi, A.W., Crippa, J.A., Hallak, J.E., Moreira, F.A., Guimaraes, F.S.Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res. 39 4: 2006 421–429.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.