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Platelet Taurine Uptake in Spinocerebellar Degeneration

Published online by Cambridge University Press:  18 September 2015

A. Filla ,
R. F. Butterworth ,
G. Geoffroy ,
B. Lemieux  and
A. Barbeau
A. Filla
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal; Hôpital Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke
R. F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal; Hôpital Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke
G. Geoffroy
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal; Hôpital Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke
B. Lemieux
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal; Hôpital Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal; Hôpital Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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The uptake of 14C-laurine was studied in the platelets of 20 ataxic patients and 20 age-matched normal control subjects. No significant differences were found in uptake or kinetics of taurine between the two groups of subjects. If a transport defect in taurine exists in Friedreich's ataxia, it is not present in all tissues. Preliminary indication was obtained in favor of heterogenity of the uptake pattern between ataxic individuals.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 119 - 123
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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