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Effects of arginine-containing total parenteral nutrition on N balance and phagocytic activity in rats undergoing a partial gastrectomy

Published online by Cambridge University Press:  08 March 2007

Chiu-Li Yeh ,
Chen-Hsien Lee ,
Soul-Chin Chen ,
Yu-Chen Hou  and
Sung-Ling Yeh
Chiu-Li Yeh
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Chen-Hsien Lee
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Soul-Chin Chen
Affiliation:
Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan
Yu-Chen Hou
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Sung-Ling Yeh*
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
*
*Corresponding author: Dr Sung-Ling Yeh, fax +886 2 27373112, email sangling@tmu.edu.tw
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Abstract

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The present study investigated the effect of arginine (Arg)-containing parenteral nutrition on phagocytic activity to elucidate the possible roles of Arg in the secretion of anabolic hormones and N balance in rats undergoing gastrectomy. Rats were divided into two experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN, the other group replaced 2 % of the total energy as Arg. After receiving TPN for 3 d, one-third of the rats in each experimental group were killed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 or 3 d after surgery. The results showed that there were no differences in N balance, plasma growth hormone and insulin-like growth factor-1 levels between the two groups before or after surgery. The phagocytic activity of peritoneal macrophages was higher in the Arg group than in the control group 1 d after surgery. There were no differences in the phagocytic activities of blood polymorphonuclear neutrophils between the two groups at various time points. TNF-α levels in peritoneal lavage fluid were lower in the Arg group than in the control group on post-operative day 3. These results suggest that parenterally infused Arg enhances phagocytic activity and reduces the production of inflammatory mediators at the site of injury. However, Arg supplementation did not influence the secretion of anabolic hormones nor N balance in rats with a partial gastrectomy.

Keywords

ArginineGastrectomyPhagocytosisNitrogen balance
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 2 , February 2005 , pp. 267 - 272
Copyright
Copyright © The Nutrition Society 2005

References

Albina, JE, Mills, CD, Barbul, A, Thirkill, CE, Henry, WL, Mastrofrancesco, B & Caldwell, MD (1988) Arginine metabolism in wounds. Am J Physiol 254, E459–E467.Google ScholarPubMed
Baigrie, RJ, Lamont, PM, Kwiatkowski, D, Dallman, MJ & Morris, PJ (1992) Systemic cytokine response after major surgery. Br J Surg 79, 757–760.CrossRefGoogle ScholarPubMed
Barbul, A, Lazarou, SA, Efron, DT, Wasserkrug, HL & Efron, G (1990) Arginine enhances wound healing and lymphocyte immune response in humans. Surgery 108, 331–337.Google ScholarPubMed
Barbul, A, Wasserkrug, HL, Yoshimura, NN, Tao, R & Efron, G (1984) High arginine levels in intravenous hyperalimentation abrogate post-traumatic immune suppression. J Surg Res 36, 620–624.Google Scholar
Biffl, WL, Moore, EE, Moore, FA & Peterson, VM (1996) Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?. Ann Surg 224, 647–664.CrossRefGoogle ScholarPubMed
Böhmer, RH, Trinkle, LS & Staneck, JL (1992) Dose effects of LPS on neutrophils in a whole blood flow cytometric assay of phagocytosis and oxidative burst. Cytometry 13, 525–531.Google Scholar
Braga, M, Gianotti, L, Andrea, V, Andrea, C, Pietro, B & Valerio, DC (1998a) Artificial nutrition after major abdominal surgery: impact of route of administration and composition of the diet. Crit Care Med 26, 24–30.Google Scholar
Braga, M, Gianotti, L, Vignali, A & Carlo, VD (1998b) Immunonutrition in gastric cancer surgical patients. Nutrition 14, 831–835.Google Scholar
Cui, XL, Iwasa, M, Iwasa, Y & Ogoshi, S (2000) Arginine-supplemented diet decreases expression of inflammatory cytokines and improves survival in burn rats. J Parenter Enter Nutr 24, 89–96.Google Scholar
Currie, GA (1978) Activated macrophages kill tumor cells by releasing arginase. Nature 273, 758–759.CrossRefGoogle ScholarPubMed
Daly, JM, Reynolds, J, Thom, A, Kinsley, L, Dietruck-Gallagher, M, Shou, J & Ruggieri, B (1988) Immune and metabolic effects of arginine in the surgical patients. Ann Surg 208, 512–523.Google Scholar
De-Souza, DA & Greene, LJ (1998) Pharmacological nutrition after burn injury. J Nutr 128, 797–803.CrossRefGoogle ScholarPubMed
Ertel, W, Morrison, MH, Wang, P, Zheng, F, Ayala, A & Chaudry, IH (1991) The complex pattern of cytokines in sepsis. Ann Surg 214, 141–148.Google Scholar
Evoy, D, Lieberman, MD, Fahey, TJ, III, Daly JM (1998) Immunonutrition: the role of arginine. Nutrition 14, 611–617.CrossRefGoogle ScholarPubMed
Finley, RJ, Inculet, RI, Pace, R, Holliday, R, Rose, C, Duff, JH, Groves, AC & Woolf, LI (1986) Major operation trauma increases peripheral amino acid release during the steady-state infusion of total parenteral nutrition in man. Surgery 99, 491–499.Google Scholar
Foex, BA & Shelly, MP (1996) The cytokine response to critical illness. J Accid Emerg Med 13, 154–162.Google Scholar
Fong, Y, Moldawer, LL, Shires, GT & Lowry, SF (1990) The biological characteristics of cytokines and their implication in surgical injury. Surg Gynecol Obstet 170, 363–373.Google Scholar
Gianotti, L, Alexander, JW, Pyles, T & Fukushima, R (1993) Arginine-supplemented diets improve survival in gut-derived sepsis and bacterial clearance. Ann Surg 217, 644–653.CrossRefGoogle ScholarPubMed
Heyland, DK, Novak, F, Drover, JW, Jain, M, Su, X & Suchner, U (2001) Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA 286, 944–953.Google Scholar
Isgaard, J, Nilsson, A & Jansson, OGP (1986) Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats. Am J Physiol 250, E367–E372.Google ScholarPubMed
Jiang, ZM, He, GZ, Zhang, SY, Wang, XR, Yang, NF, Zhu, Y & Wilmore, DW (1989) Low-dose growth hormone and hypocaloric nutrition attenuate the protein-caloric response after major operation. Ann Surg 210, 513–525.Google Scholar
Kirk, S & Barbul, A (1990) Role of arginine in trauma, sepsis, and immunity. J Parenter Enter Nutr 14, 226S–229S.Google Scholar
Lin, MT, Yeh, SL, Liaw, KY, Lee, PH, Chang, KJ & Chen, WJ (2002) Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy. Clin Nutr 21, 39–43.Google Scholar
Lindblom, L, Cassuto, J, Yregard, L, Mattsson, U, Tarnow, P & Sinclair, R (2000) Role of nitric oxide in the control of burn perfusion. Burns 26, 19–23.CrossRefGoogle ScholarPubMed
Oka, T, Ohwada, K, Nagao, M & Kitazato, K (1993) Effect of arginine-enriched total parenteral nutrition on the host–tumor interaction in cancer-bearing rats. J Parenter Enter Nutr 17, 375–383.Google Scholar
Ponting, GA, Halliday, D, Teale, JD & Sim, AJ (1988) Postoperative positive N balance with intravenous hyponutrition and growth hormone. Lancet i, 438–440.Google Scholar
Ringer, TV & Zimmermann, JJ (1992) Inflammatory host responses in sepsis. Crit Care Clin 8, 163–189.Google Scholar
Saito, H, Trocki, O, Wang, SL, Gonce, SJ, Joffe, SN & Alexander, JW (1987) Metabolic and immune effects of dietary arginine supplementation after burn. Arch Surg 122, 784–789.Google Scholar
Schiffrin, EJ, Rochat, F, Link-Amster, H, Aeschlimann, JM, Donnet-Hughes, A (1995) Immunomodulation of human blood cells following ingestion of lactic acid bacteria. J Dairy Sci 78, 491–497.Google Scholar
Shang, HF, Wang, YY, Lai, YN, Chiu, WC & Yeh, SL (2004) Effect of arginine supplementation on mucosal immunity in rats with septic peritonitis. Clin Nutr 23, 561–569.CrossRefGoogle ScholarPubMed
Tashiro, T, Yamamori, H, Takagi, K, Morishima, Y & Nakajima, N (1996) Increased contribution by myofibrillar protein to whole-body protein breakdown according to severity of surgical stress. Nutrition 12, 685–689.CrossRefGoogle ScholarPubMed
Tsai, HJ, Shang, HF, Yeh, CL & Yeh, SL (2002) Effects of arginine supplementation on antioxidant enzyme activity and macrophage response in burned mice. Burns 28, 258–263.Google Scholar
Wang, YY, Shang, HF, Lei, YN & Yeh, SL (2003) Arginine supplementation enhances peritoneal macrophage phagocytic activity in rats with gut-derived sepsis. J Parenter Enter Nutr 27, 235–240.Google Scholar
Yeh, CL, Yeh, SL, Lin, MT & Chen, WJ (2002) Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T cell population in septic rats. Nutrition 18, 631–635.CrossRefGoogle Scholar