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Existence of a genetic risk factor on chromosome 5q in Italian Coeliac Disease families

Published online by Cambridge University Press:  26 April 2001

L. GRECO
Affiliation:
Dept. of Pediatrics, University of Naples Federico II, Italy & E.L.F.I.D.
M. C. BABRON
Affiliation:
INSERM U155, Le Kremlin-Bicêtre, France
G. R. CORAZZA
Affiliation:
Dept. of Gastroenterology, IRCCS, S. Matteo Hospital, Pavia, Italy
S. PERCOPO
Affiliation:
Dept. of Pediatrics, University of Naples Federico II, Italy & E.L.F.I.D.
R. SICA
Affiliation:
Dept. of Pediatrics, University of Naples Federico II, Italy & E.L.F.I.D.
F. CLOT
Affiliation:
Lab. de Cytogénétique et Biologie Moléculaire Humaine, Univ. de Versailles, France
M. C. FULCHIGNONI-LATAUD
Affiliation:
Lab. de Cytogénétique et Biologie Moléculaire Humaine, Univ. de Versailles, France
P. ZAVATTARI
Affiliation:
Genetica Umana, Dip. Di Scienze Mediche, II Univ. di Torino, Italy
P. MOMIGLIANO-RICHIARDI
Affiliation:
Genetica Umana, Dip. Di Scienze Mediche, II Univ. di Torino, Italy
G. CASARI
Affiliation:
Tigem, Milano, Italy
P. GASPARINI
Affiliation:
Casa Sollievo Della Sofferenza, S. G. Rotondo, Italy
R. TOSI
Affiliation:
Istituto di Biologia Cellulare, CNR, Roma, Italy
V. MANTOVANI
Affiliation:
Lab. D'Analisi, Osp. Suor Orsola Malpighi, Bologna, Italy
S. DE VIRGILIIS
Affiliation:
Ist. Di Clinica e Biologia Dell'Età Evolutiva, Malattie Metaboliche, Univ. di Cagliari, Italy
G. IACONO
Affiliation:
Clinica Pediatrica, Reparto Biondo, Ospedale dei Bambini, Univ. di Palermo, Italy
A. D'ALFONSO
Affiliation:
Genetica Umana, Dip. Di Scienze Mediche, II Univ. di Torino, Italy
H. SELINGER-LENEMAN
Affiliation:
INSERM U155, Le Kremlin-Bicêtre, France
A. LEMAINQUE
Affiliation:
Centre National de Genotypage, Evry, France
J. L. SERRE
Affiliation:
Lab. de Cytogénétique et Biologie Moléculaire Humaine, Univ. de Versailles, France
F. CLERGET-DARPOUX
Affiliation:
INSERM U155, Le Kremlin-Bicêtre, France
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Abstract

Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.

Type
Research Article
Copyright
University College London 2001

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