Book contents
- Hormones and Pregnancy
- Hormones and Pregnancy
- Copyright page
- Contents
- Contributors
- Section I Hormones in the Physiology and Pharmacology of Pregnancy
- Section II Hormones and Gestational Disorders
- Chapter 8 Prolactin, Prolactinoma, and Pregnancy
- Chapter 9 Growth Hormone Disorders in Pregnancy
- Chapter 10 Gestational Diabetes
- Chapter 11 Obesity and Metabolic Syndrome in Pregnancy
- Chapter 12 Hormones and Pre-term Birth
- Chapter 13 Thyroid Dysfunction in Pregnancy and Postpartum
- Chapter 14 The Role of Hormones in Hypertensive Disorders of Pregnancy
- Chapter 15 Adrenal Disease in Pregnancy
- Chapter 16 Hormones and Multiple Pregnancy
- Chapter 17 Hormones in Pregnancy and the Developmental Origins of Health and Disease
- Index
- References
Chapter 14 - The Role of Hormones in Hypertensive Disorders of Pregnancy
from Section II - Hormones and Gestational Disorders
Published online by Cambridge University Press: 09 November 2022
Book contents
- Hormones and Pregnancy
- Hormones and Pregnancy
- Copyright page
- Contents
- Contributors
- Section I Hormones in the Physiology and Pharmacology of Pregnancy
- Section II Hormones and Gestational Disorders
- Chapter 8 Prolactin, Prolactinoma, and Pregnancy
- Chapter 9 Growth Hormone Disorders in Pregnancy
- Chapter 10 Gestational Diabetes
- Chapter 11 Obesity and Metabolic Syndrome in Pregnancy
- Chapter 12 Hormones and Pre-term Birth
- Chapter 13 Thyroid Dysfunction in Pregnancy and Postpartum
- Chapter 14 The Role of Hormones in Hypertensive Disorders of Pregnancy
- Chapter 15 Adrenal Disease in Pregnancy
- Chapter 16 Hormones and Multiple Pregnancy
- Chapter 17 Hormones in Pregnancy and the Developmental Origins of Health and Disease
- Index
- References
Summary
Hypertensive disorders of pregnancy including preeclampsia affect 5–7 percent of pregnancies and cause significant morbidity and mortality. The effects extend beyond pregnancy, being associated with increased risk of later life cardiovascular disease in the mother and programming of cardio-metabolic disease in the offspring. The profound changes in maternal metabolic and cardiovascular systems during pregnancy are mediated by altered production of hormones from the ovary, heart, brain, pineal gland, adrenal gland, and thyroid together with production and release of steroid and peptide hormones from the placenta. Production of these hormones is altered in hypertensive pregnancies, but distinction of cause from effect has been difficult to determine. Recent attention has focused on altered placental production of pro- and anti-angiogenic factors that may damage both the vasculature and renal systems. Although there is still debate as to the initiating factors for placenta dysfunction, syncytiotrophoblast stress has been postulated but without clear demonstration of cause versus effect.
- Type
- Chapter
- Information
- Hormones and PregnancyBasic Science and Clinical Implications, pp. 151 - 163Publisher: Cambridge University PressPrint publication year: 2022
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