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Major depressive disorder is associated with subsequent adult-onset asthma: a population-based cohort study‡

Published online by Cambridge University Press:  19 September 2016

T-C. Shen ,
C-L. Lin ,
C.H. Liao ,
C-C. Wei ,
F-C. Sung  and
C-H. Kao
T-C. Shen
Affiliation:
Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
C-L. Lin
Affiliation:
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
C.H. Liao
Affiliation:
Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
C-C. Wei
Affiliation:
Children's Hospital, China Medical University Hospital, Taichung, Taiwan
F-C. Sung
Affiliation:
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan Department of Health Services Administration, China Medical University, Taichung, Taiwan Faculty of Public Health, Mahidol University, Bangkok, Thailand
C-H. Kao*
Affiliation:
Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
*
*Address for correspondence: C-H. Kao, MD, Professor, Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yude Road, Taichung 404, Taiwan. (Email: d10040@mail.cmuh.org.tw)
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Abstract

Aim.

To examine the incidence of asthma in adult patients with major depressive disorder (MDD).

Methods.

From the National Health Insurance database of Taiwan, we identified 30 169 adult patients who were newly diagnosed with MDD between 2000 and 2010. Individuals without depression were randomly selected four times and frequency matched for sex, age and year of diagnosis. Both cohorts were followed-up for the occurrence of asthma up to the end of 2011. Adjusted hazard ratios (aHRs) of asthma were estimated using the Cox proportional hazards method.

Results.

The overall incidence of asthma was 1.91-fold higher in the MDD cohort than in the non-depression cohort (7.55 v. 3.96 per 1000 person-years), with an aHR of 1.66 (95% confidence interval (CI) 1.55–1.78). In both cohorts, the incidence of asthma was higher in patients and controls who were female, aged, with comorbidities and users of aspirin or beta-adrenergic receptor blockers. No significant difference was observed in the occurrence of asthma between patients with MDD treated with selective serotonin reuptake inhibitors (SSRIs) and those treated with non-SSRIs (SSRIs to non-SSRIs aHR = 1.03, 95% CI 0.91–1.17).

Conclusion.

Adult patients with MDD are at a higher risk of asthma than those without depression are.

Keywords

Asthmacohort studymajor depressive disorder (MDD)selective serotonin reuptake inhibitors (SSRIs)
Type
Original Articles
Information
Epidemiology and Psychiatric Sciences , Volume 26 , Issue 6 , December 2017 , pp. 664 - 671
Copyright
Copyright © Cambridge University Press 2016 

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Footnotes

†

These authors contributed equally to this work.

‡

There was an error of omission in the title that has now been corrected and a notice has been published providing details.

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