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Genomic and transcriptomic evaluations of infertile or subfertile Arunachali yak sperm

Published online by Cambridge University Press:  17 October 2024

Pranab Jyoti Das ,
Aneet Kour Open the ORCID record for Aneet Kour [Opens in a new window] ,
Jyotika Bhati ,
Dwijesh Chandra Mishra  and
Mihir Sarkar
Pranab Jyoti Das
Affiliation:
ICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, India ICAR-National Research Centre on Pig, Guwahati, Assam, India
Aneet Kour
Affiliation:
ICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, India ICAR-Directorate of Poultry Research, Hyderabad, Telangana, India
Jyotika Bhati
Affiliation:
ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India
Dwijesh Chandra Mishra
Affiliation:
ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India
Mihir Sarkar*
Affiliation:
ICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, India
*
Corresponding author: Mihir Sarkar; Email: msarkar24@gmail.com
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Abstract

Sperm infertility or subfertility is detrimental to the precious highland germplasm like yak whose population has been gradually declining in India. Understanding the ‘omic’ landscape of infertile or subfertile yak sperm can reveal some interesting insights. In an attempt to do the same, this study considered the semen of infertile or subfertile yak bulls for whole-genome and transcriptome evaluations. DNA sequencing revealed that the yak sperm genome contains the necessary genes to carry out all the important biological processes related to the growth, development, survival and multiplication of an organism. Interestingly, RNA Seq results highlighted that genes like VAMP7, MYLK, ARAP2 and MARCH6 showed increased expression, while biological processes related to immune response (GO:0043308, GO:0002447, GO:0002278, GO:0043307, GO:0043312, GO:0002283, GO:0043299 and GO:0002446) were significantly overrepresented. These findings hint at a possible role played by immune system in regulating infertility or subfertility in yaks. Further, in-depth studies can validate these findings and help in improving our biological understanding in this area.

Keywords

infertilityimmune responsespermsubfertilitytranscriptomeyak
Type
Research Article
Information
Zygote , Volume 32 , Issue 5 , October 2024 , pp. 341 - 347
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work and share the first authorship

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