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Associations between exposure to early childhood adversities and middle childhood psychotic experiences in children at familial high risk of schizophrenia, bipolar disorder, and population-based controls: The Danish high risk and resilience study – VIA 7 and VIA 11

Published online by Cambridge University Press:  02 February 2023

Julie Marie Brandt Open the ORCID record for Julie Marie Brandt [Opens in a new window] ,
Maja Gregersen ,
Anne Søndergaard ,
Mette Falkenberg Krantz ,
Christina Bruun Knudsen ,
Anna Krogh Andreassen ,
Lotte Veddum ,
Jessica Ohland ,
Carsten Hjorthøj  and
Martin Wilms
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Julie Marie Brandt*
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Maja Gregersen
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark
Anne Søndergaard
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Mette Falkenberg Krantz
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Mental Health Services in the Capital Region of Denmark, Child and Adolescent Mental Health Center, Copenhagen, Denmark
Christina Bruun Knudsen
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Anna Krogh Andreassen
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Lotte Veddum
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Jessica Ohland
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark
Carsten Hjorthøj
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark
Martin Wilms
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark
Sinnika Birkehøj Rohd
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark
Aja Greve
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Birgitte Klee Burton
Affiliation:
Mental Health Services in the Capital Region of Denmark, Child and Adolescent Mental Health Center, Copenhagen, Denmark Department of Child and Adolescent Psychiatry, Zealand University Hospital, Region Zealand, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Vibeke Bliksted
Affiliation:
Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Ole Mors
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University, Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Skejby, Aarhus, Denmark
Merete Nordentoft
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Anne Amalie Elgaard Thorup
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Mental Health Services in the Capital Region of Denmark, Child and Adolescent Mental Health Center, Copenhagen, Denmark
Nicoline Hemager
Affiliation:
CORE – Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH, Aarhus, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
*
Author for correspondence: Julie Marie Brandt, E-mail: julie.marie.brandt@regionh.dk
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Abstract

Background

Exposure to adversities in early childhood is associated with psychotic experiences and disorders in adulthood. We aimed to examine whether early childhood adversities are associated with middle childhood psychotic experiences in a cohort of children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (controls).

Methods

Four hundred and forty-six children from The Danish High Risk and Resilience Study – VIA7 and VIA11 participated in this study (FHR-SZ = 170; FHR-BP = 103; controls = 173). Exposure to early childhood adversities and psychotic experiences were assessed using face-to-face interviews. Having childhood adversities assessed at baseline (age 7) was used as predictor. Psychotic experiences assessed at follow-up (age 11) were used as outcome.

Results

Across the sample, exposure to early childhood interpersonal adversities was associated with an increased risk for any middle childhood psychotic experiences and subclinical delusions when adjusting for relevant confounders (OR 1.8, 95% CI 1.0–3.1, p = 0.05; OR 3.0, 95% CI 1.6–5.6, p < 0.001). There was no significant dose–response effect of exposure to multiple types of childhood adversities on any psychotic experiences. There were no interaction effects between early childhood adversities and FHR on middle childhood psychotic experiences. Exploratory analyses revealed that experiencing domestic violence in early childhood was associated with any middle childhood psychotic experiences (OR 2.8, 95% CI 1.5–5.1, p = 0.001).

Conclusions

Exposure to interpersonal adversities during early childhood is associated with an increased risk for middle childhood psychotic experiences including specifically subclinical delusions. Future studies should examine associations between exposure to childhood adversities and conversion to psychosis within this cohort.

Keywords

Bipolar disorderchildhood adversitiesfamilial high riskpsychotic experiencesschizophrenia
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 14 , October 2023 , pp. 6635 - 6645
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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References

Aas, M., Alameda, L., Di Forti, M., Quattrone, D., Dazzan, P., Trotta, A., … Morgan, C. (2021). Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: The EU-GEI study. Psychological Medicine, 1–9. https://doi.org/10.1017/S0033291721003664.Google ScholarPubMed
Alameda, L., Christy, A., Rodriguez, V., Salazar De Pablo, G., Thrush, M., Shen, Y., … Murray, R. M. (2021). Association between specific childhood adversities and symptom dimensions in people with psychosis: Systematic review and meta-analysis. Schizophrenia Bulletin, 47(4), 975–985. https://doi.org/10.1093/schbul/sbaa199.CrossRefGoogle ScholarPubMed
Alameda, L., Rodriguez, V., Carr, E., Aas, M., Trotta, G., Marino, P., … Murray, R. M. (2020). A systematic review on mediators between adversity and psychosis: Potential targets for treatment. Psychological Medicine, 50(12), 1966–1976. https://doi.org/10.1017/S0033291720002421.CrossRefGoogle ScholarPubMed
Arseneault, L., Cannon, M., Fisher, H. L., Polanczyk, G., Moffitt, T. E., & Caspi, A. (2011). Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study. American Journal of Psychiatry, 168(1), 65–72. https://doi.org/10.1176/appi.ajp.2010.10040567.CrossRefGoogle ScholarPubMed
Bentall, R. P., De Sousa, P., Varese, F., Wickham, S., Sitko, K., Haarmans, M., & Read, J. (2014). From adversity to psychosis: Pathways and mechanisms from specific adversities to specific symptoms. Social Psychiatry and Psychiatric Epidemiology, 49(7), 1011–1022. https://doi.org/10.1007/s00127-014-0914-0.CrossRefGoogle ScholarPubMed
Brandt, J. M., Hemager, N., Gregersen, M., Søndergaard, A., Krantz, M. F., Ohland, J., … Thorup, A. A. E. (2022). Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. The danish high risk and resilience study – VIA 7 and VIA 11. British Journal of Clinical Psychology, 61(4), 875–894. https://doi.org/10.1016/j.jad.2022.01.096.CrossRefGoogle ScholarPubMed
Croft, J., Heron, J., Teufel, C., Cannon, M., Wolke, D., Thompson, A., … Zammit, S. (2019). Association of trauma type, age of exposure, and frequency in childhood and adolescence with psychotic experiences in early adulthood. JAMA Psychiatry, 76(1), 79–86. https://doi.org/10.1001/jamapsychiatry.2018.3155.CrossRefGoogle ScholarPubMed
Crush, E., Arseneault, L., Jaffee, S. R., Danese, A., & Fisher, H. L. (2018). Protective factors for psychotic symptoms among poly-victimized children. Schizophrenia Bulletin, 44(3), 691–700. https://doi.org/10.1093/schbul/sbx111.CrossRefGoogle ScholarPubMed
De Loore, E., Drukker, M., Gunther, N., Feron, F., Deboutte, D., Sabbe, B., … Myin-Germeys, I. (2007). Childhood negative experiences and subclinical psychosis in adolescence: A longitudinal general population study. Early Intervention in Psychiatry, 1(2), 201–207. https://doi.org/10.1111/j.1751-7893.2007.00027.x.CrossRefGoogle Scholar
Ellersgaard, D, Gregersen, M, Soeborg Spang, K, Christiani, C, Burton, Klee, Hemager, B…Nordentoft, N. (2021). Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study - VIA7; A population-based cohort study. Schizophrenia Research, 228, 510–518. https://doi.org/10.1016/j.schres.2019.12.028.CrossRefGoogle ScholarPubMed
Ellersgaard, D., Gregersen, M., Soeborg Spang, K., Christiani, C., Klee Burton, B., Hemager, N., … Nordentoft, M. (2021). Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish high risk and resilience study – VIA7; A population-based cohort study. Schizophrenia Research, 228, 510–518. https://doi.org/10.1016/j.schres.2019.12.028.CrossRefGoogle ScholarPubMed
Fekih-Romdhane, F., Tira, S., & Cheour, M. (2019). Childhood sexual abuse as a potential predictor of psychotic like experiences in Tunisian college students. Psychiatry Research, 275(March), 181–188. https://doi.org/10.1016/j.psychres.2019.03.034.CrossRefGoogle ScholarPubMed
Fisher, H. L., McGuffin, P., Boydell, J., Fearon, P., Craig, T. K., Dazzan, P., … Morgan, C. (2014). Interplay between childhood physical abuse and familial risk in the onset of psychotic disorders. Schizophrenia Bulletin, 40(6), 1443–1451. https://doi.org/10.1093/schbul/sbt201.CrossRefGoogle ScholarPubMed
Gibson, L. E., Alloy, L. B., & Ellman, L. M. (2016). Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms. Clinical Psychology Review, 49, 92–105. https://doi.org/10.1016/j.cpr.2016.08.003.CrossRefGoogle ScholarPubMed
Goldstein, B. I., Shamseddeen, W., Axelson, D. A., Kalas, C., Monk, K., Brent, D. A., … Birmaher, B. (2010). Clinical, demographic, and familial correlates of bipolar spectrum disorders among offspring of parents with bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 49(4), 388–396. https://doi.org/10.1016/j.jaac.2010.01.009.Google ScholarPubMed
Gregersen, M., Møllegaard Jepsen, J. R., Birkehøj Rohd, S., Søndergaard, A., Brandt, J. M., Ellersgaard, D., Hjorthøj, C., … Elgaard Thorup, A. A. (2022). Developmental pathways and clinical outcomes of early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder: A prospective, longitudinal cohort study – The Danish high risk and resilience stud. American Journal of Psychiatry, 179(9), 629–639.CrossRefGoogle ScholarPubMed
Gregersen, M., Søndergaard, A., Brandt, J. M., Ellersgaard, D., Rohd, S. B., Hjorthøj, C., … Thorup, A. A. E. (2021). Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder – a four-year follow-up study: The Danish high risk and resilience study, VIA 11. Journal of Child Psychology and Psychiatry and Allied Disciplines, 179(9), 628–639. https://doi.org/10.1111/jcpp.13548.Google Scholar
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., … Ryan, N. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36(7), 980–988. https://doi.org/10.1097/00004583-199707000-00021.CrossRefGoogle ScholarPubMed
Kelleher, I., Harley, M., Lynch, F., Arseneault, L., Fitzpatrick, C., & Cannon, M. (2008). Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. British Journal of Psychiatry, 193(5), 378–382. https://doi.org/10.1192/bjp.bp.108.049536.CrossRefGoogle ScholarPubMed
Kelleher, I., Keeley, H., Corcoran, P., Ramsay, H., Wasserman, C., Carli, V., … Cannon, M. (2013). Childhood trauma and psychosis in a prospective cohort study: Cause, effect, and directionality. American Journal of Psychiatry, 170(7), 734–741. https://doi.org/10.1176/appi.ajp.2012.12091169.CrossRefGoogle Scholar
Lataster, T., Myin-Germeys, I., Derom, C., Thiery, E., & Van Os, J. (2009). Evidence that self-reported psychotic experiences represent the transitory developmental expression of genetic liability to psychosis in the general population. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(8), 1078–1084. https://doi.org/10.1002/ajmg.b.30933.CrossRefGoogle Scholar
Lataster, T., van Os, J., Drukker, M., Henquet, C., Feron, F., Gunther, N., & Myin-Germeys, I. (2006). Childhood victimisation and developmental expression of non-clinical delusional ideation and hallucinatory experiences. Social Psychiatry and Psychiatric Epidemiology, 41(6), 423–428. https://doi.org/10.1007/s00127-006-0060-4.CrossRefGoogle ScholarPubMed
Lu, D., Wang, W., Qiu, X., Qing, Z., Lin, X., Liu, F., … Liu, X. (2020). The prevalence of confirmed childhood trauma and its’ impact on psychotic-like experiences in a sample of Chinese adolescents. Psychiatry Research, 287(February), 112897. https://doi.org/10.1016/j.psychres.2020.112897.CrossRefGoogle Scholar
McGrath, J. J., McLaughlin, K. A., Saha, S., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., … Kessler, R. C. (2017). The association between childhood adversities and subsequent first onset of psychotic experiences: A cross-national analysis of 23 998 respondents from 17 countries. Psychological Medicine, 47(7), 1230–1245. https://doi.org/10.1017/S0033291716003263.CrossRefGoogle ScholarPubMed
McKay, M. T., Cannon, M., Chambers, D., Conroy, R. M., Coughlan, H., Dodd, P., … Clarke, M. C. (2020). Childhood trauma and adult mental disorder: A systematic review and meta-analysis of longitudinal cohort studies. Acta Psychiatrica Scandinavica (December 2020), 1–17. https://doi.org/10.1111/acps.13268.Google Scholar
McKay, M. T., Kilmartin, L., Meagher, A., Cannon, M., Healy, C., & Clarke, M. C. (2022). A revised and extended systematic review and meta-analysis of the relationship between childhood adversity and adult psychiatric disorder. Journal of Psychiatric Research, 156(October), 268–283. https://doi.org/10.1016/j.jpsychires.2022.10.015.CrossRefGoogle ScholarPubMed
Morgan, C., Gayer-Anderson, C., Beards, S., Hubbard, K., Mondelli, V., Di Forti, M., … Fisher, H. L. (2020). Threat, hostility and violence in childhood and later psychotic disorder: Population-based case–control study. British Journal of Psychiatry, 217(4), 575–582. https://doi.org/10.1192/bjp.2020.133.CrossRefGoogle ScholarPubMed
Muenzenmaier, K. H., Seixas, A. A., Schneeberger, A. R., Castille, D. M., Battaglia, J., & Link, B. G. (2015). Cumulative effects of stressful childhood experiences on delusions and hallucinations. Journal of Trauma and Dissociation, 16(4), 442–462. https://doi.org/10.1080/15299732.2015.1018475.CrossRefGoogle ScholarPubMed
Pfeifer, S., Krabbendam, L., Myin-Germeys, I., Derom, C., Wichers, M., Jacobs, N., … van Os, J. (2010). A cognitive intermediate phenotype study confirming possible gene–early adversity interaction in psychosis outcome: A general population twin study. Psychosis, 2(1), 1–11. https://doi.org/10.1080/17522430903197384.CrossRefGoogle Scholar
Pinckaers, F. M. E., Rotee, I. L. M., Nwosu, C. V., Krolinski, P., Smeets, A. P. W., Gülöksüz, S., … Drukker, M. (2019). Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. Social Psychiatry and Psychiatric Epidemiology, 54(9), 1045–1054. https://doi.org/10.1007/s00127-019-01711-z.CrossRefGoogle ScholarPubMed
Schäfer, I., Fisher, H. L., Aderhold, V., Huber, B., Hoffmann-Langer, L., Golks, D., … Harfst, T. (2012). Dissociative symptoms in patients with schizophrenia: Relationships with childhood trauma and psychotic symptoms. Comprehensive Psychiatry, 53(4), 364–371. https://doi.org/10.1016/j.comppsych.2011.05.010.CrossRefGoogle ScholarPubMed
Schreuder, M. M., Vinkers, C. H., Mesman, E., Claes, S., Nolen, W. A., & Hillegers, M. H. J. (2016). Childhood trauma and HPA axis functionality in offspring of bipolar parents. Psychoneuroendocrinology, 74, 316–323. https://doi.org/10.1016/j.psyneuen.2016.09.017.CrossRefGoogle ScholarPubMed
Shaffer, D., Gould, M. S., Brasic, J., Fisher, P., Aluwahlia, S., & Bird, H. (1983). A Children's Global Assessment Scale (CGAS). Archives of General Psychiatry, 40(11), 1228–1231. https://doi.org/10.1001/archpsyc.1983.01790100074010.CrossRefGoogle ScholarPubMed
Sun, P., Alvarez-Jimenez, M., Simpson, K., Lawrence, K., Peach, N., & Bendall, S. (2018). Does dissociation mediate the relationship between childhood trauma and hallucinations, delusions in first episode psychosis? Comprehensive Psychiatry, 84, 68–74. https://doi.org/10.1016/j.comppsych.2018.04.004.CrossRefGoogle ScholarPubMed
Thorup, A. A. E., Hemager, N., Søndergaard, A., Gregersen, M., Prøsch, ÅK, Falkenberg Krantz, M., … Nordentoft, M. (2018). The Danish high risk and resilience study – VIA 11: Study protocol for the first follow-up of the VIA 7 cohort − 522 children born to parents with schizophrenia spectrum disorders or bipolar disorder and controls being re-examined for the first time at A. Frontiers in Psychiatry, 9(661), 1–16. https://doi.org/10.3389/fpsyt.2018.00661.CrossRefGoogle ScholarPubMed
Thorup, A. A. E., Jepsen, J. R., Ellersgaard, D. V., Burton, B. K., Christiani, C. J., Hemager, N., … Nordentoft, M. (2015). The Danish high risk and resilience study – VIA 7 – A cohort study of 520 7-year-old children born of parents diagnosed with either schizophrenia, bipolar disorder or neither of these two mental disorders. BMC Psychiatry, 15(1), 1–15. https://doi.org/10.1186/s12888-015-0616-5.CrossRefGoogle ScholarPubMed
Tienari, P., Wynne, L., Sorri, A., Lathi, I., Läksy, K., Moring, J., … Wahlberg, K.-E. (2004). Genotype–environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees. British Journal of Psychiatry, 184, 216–222. https://doi.org/10.1016/s0084-3970(08)70266-4.CrossRefGoogle ScholarPubMed
Trotta, A., Murray, R. M., & Fisher, H. L. (2015). The impact of childhood adversity on the persistence of psychotic symptoms: A systematic review and meta-analysis. Psychological Medicine, 45(12), 2481–2498. https://doi.org/10.1017/S0033291715000574.CrossRefGoogle ScholarPubMed
Van Nierop, M., Janssens, M., Bruggeman, R., Cahn, W., De Haan, L., Kahn, R. S., … Wiersma, D. (2013). Evidence that transition from health to psychotic disorder can be traced to semi-ubiquitous environmental effects operating against background genetic risk. PLoS One, 8(11), 1–9. https://doi.org/10.1371/journal.pone.0076690.CrossRefGoogle ScholarPubMed
Van Nierop, M., Lataster, T., Smeets, F., Gunther, N., Van Zelst, C., De Graaf, R., … Van Winkel, R. (2014). Psychopathological mechanisms linking childhood traumatic experiences to risk of psychotic symptoms: Analysis of a large, representative population-based sample. Schizophrenia Bulletin, 40(Suppl. 2), 123–130. https://doi.org/10.1093/schbul/sbt150.CrossRefGoogle ScholarPubMed
Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechtbauer, W., … Bentall, R. P. (2012). Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective-and cross-sectional cohort studies. Schizophrenia Bulletin, 38(4), 661–671. https://doi.org/10.1093/schbul/sbs050.CrossRefGoogle ScholarPubMed
Wigman, J. T. W., van Winkel, R., Ormel, J., Verhulst, F. C., van Os, J., & Vollebergh, W. A. M. (2012). Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta Psychiatrica Scandinavica, 126(4), 266–273. https://doi.org/10.1111/j.1600-0447.2012.01857.x.CrossRefGoogle ScholarPubMed
Woolway, G. E., Smart, S. E., Lynham, A. J., Lloyd, J. L., Owen, M. J., Jones, I. R., … Legge, S. E. (2022). Schizophrenia polygenic risk and experiences of childhood adversity: A systematic review and meta-analysis. Schizophrenia Bulletin, 48(5), 967–980. https://doi.org/10.1093/schbul/sbac049.CrossRefGoogle ScholarPubMed