Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-18T10:33:06.411Z Has data issue: false hasContentIssue false

Transformational Organizations and a Burst of Scientific Breakthroughs

The Institut Pasteur and Biomedicine, 1889–1919

Published online by Cambridge University Press:  04 January 2016

Abstract

We use a historical case study of the Institut Pasteur to articulate the concept of the transformational organization in science, an organization with the capacity to make a large number of scientific breakthroughs in a short period of time. In considering the potential characteristics that explain a burst of scientific innovations, we attempt to move beyond the standard arguments in the management and organizational sociology literature that typically focus on complex research teams with cross-fertilization of ideas. Rather, we discuss the organizational characteristics that facilitate the development of these types of mechanisms. In doing so we address the dilemma faced by organizations seeking to assemble complex teams, that is, increasing cognitive distance. To illustrate the concept of a transformational organization, we explore the formative years of the Institut Pasteur, 1889–1919.

Type
Articles
Copyright
Copyright © Social Science History Association 2010 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bernard, P. Noël (1961) La vie et l’oeuvre de Albert Calmette. Paris: Michel.Google Scholar
Bernard, P. Noël, and Nègre, Léopold (1939) Albert Calmette: Sa vie, son oeuvre scientifique. Paris: Masson.Google Scholar
Bertrand, Gabriel (1962) “Nécrologie.” Compte rendu, Académie des Sciences 255: 217–22.Google Scholar
Bordet, Jules (1961) “Nécrologie.” Les annales de l’Institut Pasteur 101: 14.Google Scholar
Brown, E. A. (1998) Reinventing Government Research and Development: A Status Report on Management Initiatives and Reinvention Efforts at the Army Research Laboratory. ARL-SR-57, Army Research Laboratory, Adelphi, MD.Google Scholar
Brown, Shona L., and Eisenhardt, Kathleen M. (1995) “Product development: Past research, present findings, and future directions.” Academy of Management Review 20: 343–78.Google Scholar
Burns, Tom R., and Stalker, G. M. (1994) The Management of Innovation. Oxford: Oxford University Press.Google Scholar
Calmette, Albert (1921) “L’oeuvre de l’Institut Pasteur pendant la guerre.” Revue d’Hygiène 43: 463.Google Scholar
Campbell, Donald, et al. (1966) Experimental and Quasi-Experimental Designs for Research. Chicago: Rand McNally.Google Scholar
Caullery, Maurice (1975) French Science and Its Principal Discoveries since the Seventeenth Century. New York: Arno.Google Scholar
Coccia, Mario (2001) “A basic model for evaluating R & D performance: Theory and application in Italy.” R & D Management 31: 453–64.Google Scholar
Cohen, Michael D., and Sproull, Lee S. (1995) Organizational Learning. Newbury Park, CA: Sage.Google Scholar
Conner, Kathleen R., and Prahalad, C. K. (1996) “A resource-based theory of the firm: Knowledge versus opportunism.” Organization Science 7: 477501.10.1287/orsc.7.5.477Google Scholar
Cressac, Mary (1950) Le docteur Roux: Mon oncle. Paris: Arche.Google Scholar
Damanpour, Fariborz (1991) “Organizational innovation: A meta-analysis of effects of determinants and moderators.” Academy of Management Journal 34: 555–90.Google Scholar
Debré, Patrice (1994) Louis Pasteur. Paris: Flammarion.Google Scholar
Debru, Claude (1991) “Actualité d’Emile Duclaux,” in Morange, Michel (ed.) L’Institut Pasteur: Contributions à son histoire. Paris: Découverte: 107–14.Google Scholar
Debru, Claude (n.d.) “The logic of non-profit.” Unpublished manuscript.Google Scholar
Dedet, Jean-Pierre (2000) Les Instituts Pasteur d’Outre-mer. Paris: Harmattan.Google Scholar
Delaunay, Albert (1962) L’Institut Pasteur des origines à nos jours. Paris: France-Empire.Google Scholar
Faure, Marguerite (1988) “Histoire des cours de l’Institut Pasteur.” Institut Pasteur Archives. Unpublished manuscript.Google Scholar
Fourneau, Jean-Pierre (1988) La chimie thérapeutique à l’Institut Pasteur: Histoire des pasteuriens. Paris: Institut Pasteur.Google Scholar
Gascar, Pierre (1986) Du côté de chez Monsieur Pasteur. Paris: Jacob.Google Scholar
Geison, Gerald L. (1995) The Private Science of Louis Pasteur. Princeton, NJ: Princeton University Press.Google Scholar
Gibbons, Michael (1994) The New Production of Knowledge: The Dynamics of Science and Research in Contemporary Societies. London: Sage.Google Scholar
Grant, R. M. (1996) “Prospering in dynamically-competitive environments: Organizational capability as knowledge integration.” Organization Science 7: 375–87.Google Scholar
Grimaldi, R., and von Tunzelmann, N. (2002) “Assessing collaborative, pre-competitive R & D projects: The case of the UK LINK scheme.” R & D Management 32: 165–73.10.1111/1467-9310.00248Google Scholar
Hage, Jerald (1980) Theories of Organizations: Form, Process, and Transformation. New York: Wiley.Google Scholar
Hage, Jerald (1999) “Organizational innovation and organizational change.” Annual Review of Sociology 25: 597622.Google Scholar
Hage, Jerald, and Rogers Hollingsworth, J. (2000) “A strategy for the analysis of idea innovation networks and institutions.” Organization Studies 21: 9711004.Google Scholar
Hage, Jerald, et al. (2007) “R & D integration: How to build a diverse and integrated knowledge community.Paper presented at the Portland International Center for Management of Engineering and Technology, Portland, OR, August 5–9.Google Scholar
Hauser, J. R., and Zettelmery, Florian (1997) “Metrics to evaluate RD&E.” Research Technology Management 40: 3238.10.1080/08956308.1997.11671140Google Scholar
Hollingsworth, J. Rogers (2006) “A path-dependent perspective on institutional and organizational factors shaping major scientific discoveries,” in Hage, Jerald and Meeus, Marius T. H. (eds.) Innovation, Science, and Institutional Change: A Research Handbook. London: Oxford University Press: 423–42.Google Scholar
Institut Pasteur (1938) MDCCCLXXXVIII–MCMXXXVIII Cinquantenaire de la Fondation. Paris: Institut Pasteur.Google Scholar
Institut Pasteur (n.d.) Les séances du Conseil d’Administration et de l’Assemblée Générale. Archives, Institut Pasteur, Paris.Google Scholar
Jordan, Gretchen B., et al. (2003) Attributes in the Research Environment That Foster Excellent Research: An Annotated Bibliography. SAND 2003–0132. Albuquerque, NM: Sandia National Laboratories.10.2172/808620Google Scholar
Kanter, Rosabeth Moss (1988) “When a thousand flowers bloom: Structural, collective, and social conditions for innovation in organizations.” Research in Organizational Behavior 10: 169.Google Scholar
Kim, J., and Wilemon, D. (2003) “Sources and assessment of complexity in NPD projects.” R & D Management 33: 1630.Google Scholar
Lacroix, Alfred (1934) Rapport de la Commission Lacroix pour la réorganisation de l’Institut Pasteur à la mort d’Emile Roux. Archives, Institut Pasteur, Paris.Google Scholar
Lagrange, Emile (1954) Monsieur Roux. Brussels: Goemaere.Google Scholar
Lapresle, Claude (1991) “Le rôle de l’hôpital de l’Institut Pasteur dans l’application à la médecine de découverte fondamentale,” in Morange, Michel (ed.) L’Institut Pasteur: Contributions à son histoire. Paris: Découverte: 4551.Google Scholar
Latour, Bruno (1988) The Pasteurization of France. Cambridge, MA: Harvard University Press.Google Scholar
Lawrence, Paul R., and Lorsch, Jay W. (1967) Organization and Environment: Managing Differentiation and Integration. Boston: Division of Research, Graduate School of Business Administration, Harvard University.Google Scholar
Legout, Sandra (1999) La famille pasteurienne: Le personnel scientifique permanent de l’Institut Pasteur de Paris entre 1889 et 1914. Paris: Ecole des Hautes Etudes en Science Sociale.Google Scholar
Leifer, Richard, et al. (2000). Radical Innovation: How Mature Companies Can Outsmart Upstarts. Boston: Harvard Business School Press.Google Scholar
Lépine, Pierre (1966) Metchnikoff: Présentation, choix de textes, bibliographie, portraits, facsimile. Paris: Seghers.Google Scholar
Levaditi, Constantin (1953) “Nécrologie.” Les annales de l’Institut Pasteur 85: 535–39.Google Scholar
Levin, Daniel Z., and Cross, Rob (2004) “The strength of weak ties you can trust: The mediating role of trust in effective knowledge transfer.” Management Science 50: 1477–90.Google Scholar
Lowy, Ilana (1994) “On hybridizations, networks, and new disciplines: The Pasteur Institute and the development of microbiology in France.” Studies in the History and Philosophy of Science 25: 655–88.Google Scholar
Mayer, Jean (1954) “Science,” in Park, Julian (ed.) The Culture of France in Our Time. Ithaca, NY: Cornell University Press: 266336.Google Scholar
Meeus, Marius T. H., and Hage, Jerald (2006) “Product and process innovation, scientific research, knowledge dynamics, and institutional change: An introduction,” in Hage, Jerald and Meeus, Marius T. H. (eds.) Innovation, Science, and Institutional Change: A Research Handbook. London: Oxford University Press: 122.Google Scholar
Mendelsohn, Andrew (1996) “Cultures of bacteriology: Formation and transformation of a science in France and Germany, 1870–1914.” PhD diss., Princeton University.Google Scholar
Méry, Jacques (1987) Histoire des Legs à l’Institut Pasteur: Histoire et histories. Paris: Institut Pasteur Archives.Google Scholar
Metchnikoff, Olga (1920) Vie d’Elie Metchnikoff. Paris: Hachette.Google Scholar
Miller, Roger (1995) “The new agenda for R & D: Strategy and integration.” International Journal of Technology Management 10: 511–24.Google Scholar
Mohrman, Susan A., et al. (2006) “Network attributes impacting the generation and flow of knowledge within and from the basic science community,” in Hage, Jerald and Meeus, Marius T. H. (eds.) Innovation, Science, and Institutional Change: A Research Handbook. London: Oxford University Press: 196216.Google Scholar
Mollaret, Henri, and Brossollet, Jacqueline (1985) Alexandre Yersin, le vainqueur de la peste. Paris: Fayard.Google Scholar
Morange, Michel (1990) “L’histoire de l’Institut Pasteur.” Les cahiers pour l’histoire du CNRS 10: 103–20.Google Scholar
Morange, Michel, ed. (1991) L’Institut Pasteur: Contributions à son histoire. Paris: Découverte.Google Scholar
Moulin, Anne-Marie (1994) “Bacteriological research and medical practice in and out of the Pastorian school,” in La Berge, Ann and Feingold, Mordechai (eds.) French Medical Culture in the Nineteenth Century. Amsterdam: Rodopi: 327–49.10.1163/9789004418356_015Google Scholar
Moulin, Anne-Marie, and Guenel, Annick (1993) “L’Institut Pasteur et la naissance de l’industrie de la santé,” in Beaune, Jean-Claude (ed.) La philosophie du remède. Seyssel: Champ Vallon: 91109.Google Scholar
National Academies Committee on Prospering in the Global Economy of the 21st Century (U.S.) (2005) Rising above the Gathering Storm: Energizing and Employing America for a Brighter Economic Future. Washington, DC: National Academies Press.Google Scholar
Nelson, Richard R., and Winters, Sidney G. (1982) An Evolutionary Theory of Economic Change. Cambridge, MA: Harvard University Press.Google Scholar
Nicolle, Jacques (1957) Maurice Nicolle, 1862–1932: Un homme de la Renaissance à notre époque. Paris: Colombe.Google Scholar
Nonaka, Ikujiro, and Takeuchi, Hirotaka (1995) The Knowledge-Creating Company: How Japanese Companies Create the Dynamics of Innovation. Oxford: Oxford University Press.Google Scholar
Nooteboom, Bart (1999) Inter-firm Alliances: Analysis and Design. London: Routledge.10.4324/9780203265277Google Scholar
Parish, J. H. (1965) A History of Immunization. Edinburgh: Livingstone.Google Scholar
Pelis, Kim (1995) “Pasteur’s imperial missionary: Charles Nicolle, 1866–1936, and the Pasteur Institute of Tunis.” PhD diss., Johns Hopkins University.Google Scholar
Pelis, Kim (1997) “Prophet for profit in French North Africa: Charles Nicolle and the Pasteur Institute of Tunis, 1903–1936.” Bulletin of the History of Medicine 71: 583622.Google Scholar
Pelz, D. C., and Andrews, F. M. (1976) Scientists in Organizations: Productive Climates for Research and Development. New York: Wiley.Google Scholar
Pettigrew, Andrew M. (1979) “On studying organizational cultures.” Administrative Science Quarterly 24: 570–81.Google Scholar
Polanyi, Michael (1966) The Tacit Dimension. London: Routledge.Google Scholar
Rammert, Werner (2006) “Two styles of knowing and knowledge regimes: Between ‘explicitation’ and ‘exploration’ under conditions of functional specialization or fragmental distribution,” in Hage, Jerald and Meeus, Marius T. H. (eds.) Innovation, Science, and Institutional Change: A Research Handbook. London: Oxford University Press: 256–86.Google Scholar
Robinson, Mary (1906) La vie d’Emile Duclaux. Laval, Quebec, Canada: Barneoud.Google Scholar
Saleh, S. D., and Wang, C. K. (1993) “The management of innovation: Strategy, structure, and organizational climate.” IEEE Transactions on Engineering Management 40: 1421.Google Scholar
Saleh, S. D., et al. (2000). “The role of contract type in the success of R & D defense project under increasing uncertainty.” Project Management Journal 31: 1422.Google Scholar
Schumann, P. A. Jr., et al. (1995) “Measuring R & D performance.” Research Technology Management 38: 4554.Google Scholar
Seidell, Atherton (1926) “Chemical research at the Pasteur Institute.” Journal of Chemical Education 3: 1217–39.10.1021/ed003p1217Google Scholar
Stokes, Donald E. (1997) Pasteur’s Quadrant. Washington, DC: Brookings Institution Press.Google Scholar
Verhaeghe, Audrey, and Kfir, Rivka (2002) “Managing innovation in a knowledge intensive technology organisation.” R & D Management 32: 409–17.Google Scholar
Weindling, Paul (1991) “Emile Roux et la diphtérie,” in Morange, Michel (ed.) L’Institut Pasteur: Contributions à son histoire. Paris: Découverte: 137–45.Google Scholar
Weindling, Paul (1992) “Scientific elites and laboratory organization in fin de siècle Paris and Berlin: The Pasteur Institute and Robert Koch’s Institute for Infectious Diseases compared,” in Cunningham, Andrew and Williams, Perry (eds.) The Laboratory Revolution in Medicine. Cambridge: Cambridge University Press: 170–88.Google Scholar
Wollman, Elie (1991) “Introduction,” in Morange, Michel (ed.) L’Institut Pasteur: Contributions à son histoire. Paris: Découverte: 105–7.Google Scholar
Zammuto, Raymond F., and O’Connor, Edward J. (1992) “Gaining advanced manufacturing technologies’ benefits: The roles of organization design and culture.” Academy of Management Review 17: 701–29.Google Scholar