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Longitudinal analysis of a two-component model of the memory deficit in Alzheimer's disease

Published online by Cambridge University Press:  09 July 2009

James T. Becker ,
Olurotimi Bajulaiye  and
Christine Smith
James T. Becker*
Affiliation:
Alzheimer's Disease Research Center, Departments of Psychiatry and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Olurotimi Bajulaiye
Affiliation:
Alzheimer's Disease Research Center, Departments of Psychiatry and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Christine Smith
Affiliation:
Alzheimer's Disease Research Center, Departments of Psychiatry and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
*
1Address for correspondence: Dr James T. Becker, Neuropsychology Research Program, Suite 502 – Iroquois Building, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA.
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Synopsis

The memory deficit in Alzheimer's disease (AD) has been characterized as consisting of multiple components. The purpose of this study was to confirm the utility of a two-process model, and to examine changes in the nature and extent of the neuropsychological deficits after a one-year interval. The results replicate the initial observation that the memory loss in AD can be described as consisting of a focal amnesic syndrome and a dysexecutive syndrome characterized by failure of rapid information processing and search of both episodic and semantic memory. One year after the initial observation, all dysexecutive patients and the majority of the amnesic patients had become non-focal. No patient developed a dysexecutive syndrome, but 18 patients developed amnesic syndromes. These results suggest that, like other aspects of the cognitive deficits of AD, the memory loss is multifactorial. These results have implications for understanding the pathophysiology of AD, and for designing pharmacotherapeutic intervention.

Type
Original Articles
Information
Psychological Medicine , Volume 22 , Issue 2 , May 1992 , pp. 437 - 445
Copyright
Copyright © Cambridge University Press 1992

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References

Alzheimer, A. (1907). Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift für Psychiatrie und Psychischgerichtliche Medicin 64, 146–148.Google Scholar
Baddeley, A. D. (1983). Working memory. Philosophical Transactions of the Royal Society B 302, 311–324.Google Scholar
Baddeley, A. D. (1986). Working Memory. Oxford University Press: Oxford.Google ScholarPubMed
Baddeley, A. & Wilson, B. (1988). Frontal amnesia and the dysexecutive syndrome. Brain and Cognition 7, 212–230.CrossRefGoogle ScholarPubMed
Baddeley, A., Logie, R., Bressi, S., Della Sala, S. & Spinnler, H. (1986). Senile dementia and working memory. Quarterly Journal of Experimental Psychology 38 A, 603–618.CrossRefGoogle Scholar
Baddeley, A. D., Della Salla, S. & Spinnler, H. (1991). The two component hypothesis of memory deficit in Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology 13, 372–380.CrossRefGoogle ScholarPubMed
Becker, J. T. (1988). Working memory and secondary memory deficits in Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology 10, 739–753.CrossRefGoogle ScholarPubMed
Becker, J. T., Boller, F., Saxton, J. & McGonigle-Gibson, K. (1987). Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease. Cortex 25, 59–72.CrossRefGoogle Scholar
Becker, J. T., Huff, F. J., Nebes, R. D., Holland, A. & Boller, F. (1988). Neuropsychological function in Alzheimer's disease: pattern of impairment and rates of progression. Archives of Neurology 45, 263–268.CrossRefGoogle ScholarPubMed
Benton, A. L. & Hamsher, K. (1978). Multilingual Aphasia Examination. University of Iowa: Iowa City.Google Scholar
Boller, F., Lopez, O. L. & Moossy, J. (1989). Diagnosis of dementia: clinicopathological correlations. Neurology 39, 76–79.CrossRefGoogle Scholar
Capitani, E., Della Sala, S. & Spinnler, H. (1985). Neuropsychological approach to dementia. In Neurology (ed. Poeck, K. and Gaensehirt, B. H. J.), pp. 61–69. Springer-Verlag: Berlin.Google Scholar
Chapman, L. F. & Wolff, H. G. (1959). The cerebral hemispheres and the highest integrative functions of man. American Medical Association Archives of Neurology 1, 357–424.Google ScholarPubMed
Corkin, S. (1982) Some relationships between global amnesia and the memory impairment in Alzheimer's disease. In Alzheimer's Disease: A Report of Progress in Research (ed. Corkin, S., Davis, K. L., Growden, J. H., Usdin, E. and Wurtman, J.), pp. 149–164. Raven Press: New York.Google Scholar
Diller, L., Ben-Yishay, Y., Gerstman, L. J., Goodkin, R., Gordon, W. & Weinberg, J. (1974). Studies in Cognition and Rehabilitation in Hemiplegia (Rehabilitation Monograph No. 50). New York University: New York.Google Scholar
Grossi, D., Lopez, O. L. & Martinez, A. J. (1989). Mamillary bodies in Alzheimer's disease. Acta Neurologica Scandinavica 80, 41–45.CrossRefGoogle ScholarPubMed
Haxby, J. V., Grady, C. L., Koss, E., Horwitz, B., Schapiro, M., Friedland, R. P. & Rappoport, S. I. (1988). Heterogenous anterior-posterior metabolic patterns in dementia of the Alzheimer type. Neurology 38, 1853–1863.CrossRefGoogle ScholarPubMed
Huff, J., Becker, J. T., Belle, S. H., Nebes, R. D., Holland, A. & Boller, F. (1987). Cognitive deficits and clinical diagnosis of Alzheimer's disease. Neurology 37, 1119–1124.CrossRefGoogle ScholarPubMed
Huff, F. J., Protech, J., Saxton, J. & Becker, J. T. (1989). A comparison of measures of memory impairment for use in the diagnosis of Alzheimer's disease. Neuropsychology 3, 29–40.CrossRefGoogle Scholar
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R. & Barnes, C. L. (1984). Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225, 1168–1170.CrossRefGoogle ScholarPubMed
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J. & Damasio, A. R. (1986). Perforant pathway changes and the memory impairment of Alzheimer's disease. Annals of Neurology 20, 472–481.CrossRefGoogle ScholarPubMed
Inglis, J. (1957). An experimental study of learning and ‘memory function’ in elderly psychiatric patients. Journal of Mental Sciences 103, 796–803.CrossRefGoogle ScholarPubMed
Jorm, A. F. (1985). Subtypes of Alzheimer's dementia: a conceptual analysis and critical review. Psychological Medicine 15, 543–553.CrossRefGoogle ScholarPubMed
Khachaturian, Z. A. (1985). Diagnosis of Alzheimer's disease. Archives of Neurology 42, 1097–1105.CrossRefGoogle ScholarPubMed
Kopelman, M. D. (1985 a). Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia 23, 623–638.CrossRefGoogle ScholarPubMed
Kopelman, M. D. (1985 b). Multiple memory deficits in Alzheimer-type dementia: implications of pharmaco-therapy. Psychological Medicine 15, 527–541.CrossRefGoogle Scholar
Kopelman, M. D. & Corn, T. H. (1988). Cholinergic ‘blockade’ as a model for cholinergic depletion. A comparison of the memory deficits with those of Alzheimer-type dementia and the alcoholic Korsakoff syndrome. Brain 111, 1079–1110.CrossRefGoogle Scholar
Lezak, M. (1983). Neuropsychological Assessment, 2nd edn.Oxford University Press: New York.Google Scholar
Lopez, O. L., Boller, F., Becker, J. T., Miller, M. & Reynolds, C. F. III (1990). Alzheimer's disease and depression: neuropsychological impairment and progression of illness. American Journal of Psychiatry 147, 855–860.Google Scholar
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease. Neurology 34, 939–944.CrossRefGoogle ScholarPubMed
Martin, A. (1990). Neuropsychology of Alzheimer's disease: the case for subgroups. In Modular Deficits in Alzheimer's-type Dementia (ed. Schwartz, M. F.). Bradford/MIT: Bradford.Google Scholar
Martin, A., Brouwers, P., Lalonde, F., Cox, C., Teleska, P., Fedio, P., Foster, N. L. & Chase, T. N. (1986). Towards a behavioral typology of Alzheimer's patients. Journal of Clinical and Experimental Neuropsychology 8, 594–610.CrossRefGoogle ScholarPubMed
Miller, E. (1973). Short- and long-term memory in patients with presenile dementia (Alzheimer's disease). Psychological Medicine 3, 221–224.CrossRefGoogle Scholar
Milner, B., Corkin, S. & Teuber, H. L. (1968). Further analysis of the hippocampal amnesic syndrome: 14-year follow-up study of H.M. Neuropsychologia 6, 215–234.CrossRefGoogle Scholar
Morris, R. G. (1984). Dementia and the functioning of the articulatory loop system. Cognitive Neuropsychology 1, 143–157.CrossRefGoogle Scholar
Morris, R. G. and Baddeley, A. D. (1988) Primary memory function in Alzheimer-type dementia. Journal of Clinical and Experimental Neuropsychology 10, 279–296.CrossRefGoogle ScholarPubMed
Morris, R. G. and Kopelman, M. D. (1986). The memory deficits in Alzheimer-type dementia: a review. Quarterly Journal of Experimental Psychology 38 A, 575–602.CrossRefGoogle Scholar
Neary, D., Snowden, J. S., Northen, B. & Goulding, P. (1988). Dementia of the frontal lobe type. Journal of Neurology, Neurosurgery and Psychiatry 51, 353–361.CrossRefGoogle ScholarPubMed
Osterreith, P. A. (1944). LeTest de copie d'une figure complex: contribution à l'étude de la perception et de la mémoire. Archives of Psychology 30, 206–356.Google Scholar
Rey, A. (1941). L'examen psychologique dans les cas d'encéphalopathie traumatique. Archives of Psychology 28, 286–340.Google Scholar
Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society B 298, 199–209.Google ScholarPubMed
Stuss, D. T. & Benson, D. F. (1986). The Frontal Lobes, Raven Press: New York.Google Scholar
Wechsler, D. (1955). Wechsler Adult Intelligence Scale (Manual). Psychological Corporation: New York.Google Scholar
Weigl, E. (1927). On the psychology of so-called processes of abstraction. Journal of Abnormal and Social Psychology 36, 3–33.CrossRefGoogle Scholar
Wilson, R. S., Bacon, L. D., Fox, J. H. & Kaszniak, A. W. (1983). Primary memory and secondary memory in dementia of the Alzheimer type. Journal of Clinical Neuropsychology 5, 337.CrossRefGoogle ScholarPubMed