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Childhood stressors in the development of fatigue syndromes: a review of the past 20 years of research

Published online by Cambridge University Press:  07 October 2013

A. Borsini ,
N. Hepgul ,
V. Mondelli ,
T. Chalder  and
C. M. Pariante
A. Borsini
Affiliation:
Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
N. Hepgul
Affiliation:
Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
V. Mondelli
Affiliation:
Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
T. Chalder
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
C. M. Pariante*
Affiliation:
Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
*
* Address for correspondence: Professor C. M. Pariante, Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK. (Email: carmine.pariante@kcl.ac.uk)
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Abstract

Background

Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are both highly prevalent conditions associated with extreme disability and with the development of co-morbid psychiatric disorders, such as depression and anxiety. Childhood stressors have been shown to induce persistent changes in the function of biological systems potentially relevant to the pathogenesis of both CFS and FM, such as the inflammatory system and the hypothalamic–pituitary–adrenal (HPA) axis. In this review, we examined whether multiple forms of childhood stressors are contributing factors to the development of these disorders, and of the associated psychiatric symptoms.

Method

Using PubMed, we identified 31 papers relevant to this narrative review. We included cohort studies and case-control studies, without any exclusion in terms of age and gender. No study characteristics or publication date restrictions were imposed.

Results

Most studies across the literature consistently show that there is a strong association between experiences of childhood stressors and the presence of CFS and FM, with rates of CFS/FM being two- to three-fold higher in exposed than in unexposed subjects. We also found evidence for an increased risk for the development of additional symptoms, such as depression, anxiety and pain, in individuals with CFS and FM with a previous history of childhood stressors, compared with individuals with CFS/FM and no such history.

Conclusions

Our review confirms that exposure to childhood stressors is associated with the subsequent development of fatigue syndromes such as CFS and FM, and related symptoms. Further studies are needed to identify the mechanisms underlying these associations.

Keywords

Anxietychildhood abusechildhood maltreatmentchronic fatigue syndromechronic paindepressionfibromyalgiastress
Type
Review Article
Information
Psychological Medicine , Volume 44 , Issue 9 , July 2014 , pp. 1809 - 1823
Copyright
Copyright © Cambridge University Press 2013 

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References

Anderberg, UM, Marteinsdottir, I, Theorell, T, von Knorring, L (2000). The impact of life events in female patients with fibromyalgia and in female healthy controls. European Psychiatry 15, 295–301.Google Scholar
Arnow, BA (2004). Relationships between childhood maltreatment, adult health and psychiatric outcomes, and medical utilization. Journal of Clinical Psychiatry 65, 10–15.Google ScholarPubMed
Bell, IR, Lewis, DA 2nd, Brooks, AJ, Schwartz, GE, Lewis, SE, Caspi, O, Cunningham, V, Baldwin, CM (2004). Individual differences in response to randomly assigned active individualized homeopathic and placebo treatment in fibromyalgia: implications of a double-blinded optional crossover design. Journal of Alternative and Complementary Medicine 10, 269–283.Google Scholar
Bernstein, DP, Fink, L (1998). Childhood Trauma Questionnaire: A Retrospective Self-Report Manual. The Psychological Corporation: San Antonio, TX.Google Scholar
Boisset-Pioro, MH, Esdaile, JM, Fitzcharles, MA (1995). Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis and Rheumatology 38, 235–241.CrossRefGoogle ScholarPubMed
Bremner, D, Vermetten, E, Kelley, ME (2007). Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder. Journal of Nervous and Mental Disease 195, 919–927.Google Scholar
Bremner, JD, Vythilingam, M, Anderson, G, Vermetten, E, McGlashan, T, Heninger, G, Rasmusson, A, Southwick, SM, Charney, DS (2003). Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder. Biological Psychiatry 54, 710–718.CrossRefGoogle Scholar
Brooks, SK, Rimes, KA, Chalder, T (2011). The role of acceptance in chronic fatigue syndrome. Journal of Psychosomatic Research 71, 411–415.Google Scholar
Carpenter, LL, Carvalho, JP, Tyrka, AR, Wier, LM, Mello, AF, Mello, MF, Anderson, GM, Wilkinson, CW, Price, LH (2007). Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biological Psychiatry 62, 1080–1087.CrossRefGoogle ScholarPubMed
Carpenter, LL, Gawuga, CE, Tyrka, AR, Lee, JK, Anderson, GM, Price, LH (2010). Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35, 2617–2623.Google Scholar
Carpenter, MT, Hugler, R, Enzenauer, RJ, Des Rosier, KF, Kirk, JM, Brehm, WT (1998). Physical and sexual abuse in female patients with fibromyalgia. Journal of Clinical Rheumatology 4, 301–306.CrossRefGoogle ScholarPubMed
Caseras, X, Mataix-Cols, D, Giampietro, V, Rimes, KA, Brammer, M, Zelaya, F, Chalder, T, Godfrey, EL (2006). Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task. Psychosomatic Medicine 68, 947–955.CrossRefGoogle ScholarPubMed
Caseras, X, Mataix-Cols, D, Rimes, KA, Giampietro, V, Brammer, M, Zelaya, F, Chalder, T, Godfrey, E (2008). The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychological Medicine 38, 941–951.Google Scholar
Catley, D, Kaell, AT, Kirschbaum, C, Stone, AA (2000). A naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis. Arthritis Care and Research 13, 51–61.Google Scholar
CDC (2012 a). Chronic Fatigue Syndrome (CFS) Case Definition. Centers for Disease Control and Prevention (www.cdc.gov/cfs/case-definition/index.html). Accessed 2 July 2013.Google Scholar
CDC (2012 b). Fibromyagia. Centers for Disease Control and Prevention (www.cdc.gov/arthritis/basics/fibromyalgia.htm). Accessed 2 July 2013.Google Scholar
Cella, M, White, PD, Sharpe, M, Chalder, T (2013). Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome. Psychological Medicine 43, 375–380.Google Scholar
Chartier, MJ, Walker, JR, Naimark, B (2009). Health risk behaviors and mental health problems as mediators of the relationship between childhood abuse and adult health. American Journal of Public Health 99, 847–854.Google Scholar
Chen, LP, Murad, MH, Paras, ML, Colbenson, KM, Sattler, AL, Goranson, EN, Elamin, MB, Seime, RJ, Shinozaki, G, Prokop, LJ, Zirakzadeh, A (2010). Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clinic Proceedings 85, 618–629.CrossRefGoogle ScholarPubMed
Cho, HJ, Skowera, A, Cleare, A, Wessely, S (2006). Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology. Current Opinion in Psychiatry 19, 67–73.Google Scholar
Chou, KL (2013). Chronic fatigue and affective disorders in older adults: evidence from the 2007 British National Psychiatric Morbidity Survey. Journal of Affective Disorders 145, 331–335.Google Scholar
Ciccone, DS, Elliott, DK, Chandler, HK, Nayak, S, Raphael, KG (2005). Sexual and physical abuse in women with fibromyalgia syndrome: a test of the trauma hypothesis. Clinical Journal of Pain 21, 378–386.CrossRefGoogle ScholarPubMed
Clark, C, Goodwin, L, Stansfeld, SA, Hotopf, M, White, PD (2011). Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort. British Journal of Psychiatry 199, 323–329.CrossRefGoogle ScholarPubMed
Cleare, AJ (2004). The HPA axis and the genesis of chronic fatigue syndrome. Trends in Endocrinology and Metabolism 15, 55–59.Google Scholar
Crofford, LJ, Pillemer, SR, Kalogeras, KT, Cash, JM, Michelson, D, Kling, MA, Sternberg, EM, Gold, PW, Chrousos, GP, Wilder, RL (1994). Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis and Rheumatism 37, 1583–1592.Google Scholar
Crofford, LJ, Young, EA, Engleberg, NC, Korszun, A, Brucksch, CB, McClure, LA, Brown, MB, Demitrack, MA (2004). Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain, Behavior, and Immunity 18, 314–325.CrossRefGoogle ScholarPubMed
Danese, A, McEwen, BS (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology and Behaviour 106, 29–39.Google Scholar
Danese, A, Moffitt, TE, Harrington, H, Milne, BJ, Polanczyk, G, Pariante, CM, Poulton, R, Caspi, A (2009). Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Archives of Pediatrics and Adolescent Medicine 163, 1135–1143.CrossRefGoogle ScholarPubMed
Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry 65, 409–415.CrossRefGoogle ScholarPubMed
Danese, A, Pariante, CM, Caspi, A, Taylor, A, Poulton, R (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences USA 104, 1319–1324.Google Scholar
Di Giorgio, A, Hudson, M, Jerjes, W, Cleare, AJ (2005). 24-hour pituitary and adrenal hormone profiles in chronic fatigue syndrome. Psychosomatic Medicine 67, 433–440.Google Scholar
Epstein, SA, Kay, G, Clauw, D, Heaton, R, Klein, D, Krupp, L, Kuck, J, Leslie, V, Masur, D, Wagner, M, Waid, R, Zisook, S (1999). Psychiatric disorders in patients with fibromyalgia: a multicenter investigation. Psychosomatics 40, 57–63.Google Scholar
Finestone, HM, Stenn, P, Davies, F, Stalker, C, Fry, R, Koumanis, J (2000). Chronic pain and health care utilization in women with a history of childhood sexual abuse. Child Abuse and Neglect 24, 547–556.CrossRefGoogle ScholarPubMed
Fuite, J, Vernon, SD, Broderick, G (2008). Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis. Genomics 92, 393–399.Google Scholar
Goldberg, RT, Pachas, WN, Keith, D (1999). Relationship between traumatic events in childhood and chronic pain. Disability and Rehabilitation 21, 23–30.Google Scholar
Griep, EN, Boersma, JW, de Kloet, ER (1993). Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. Journal of Rheumatology 20, 469–474.Google ScholarPubMed
Gunnar, MR, Vazquez, DM (2001). Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development. Development and Psychopathology 13, 515–538.Google Scholar
Häuser, W (2005). Fibromyalgia in the legal procedures of the German sozialgericht – psychosocial risk factors and predictors of health care utilization [in German]. Psychotherapy, Psychosomatik, Medizinische Psychologie 55, 72–78.Google Scholar
Häuser, W, Kosseva, M, Uceyler, N, Klose, P, Sommer, C (2011). Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. Arthritis Care and Research (Hoboken) 63, 808–820.CrossRefGoogle ScholarPubMed
Heath, NM, Chesney, SA, Gerhart, JI, Goldsmith, RE, Luborsky, JL, Stevens, NR, Hobfoll, SE (2013). Interpersonal violence, PTSD, and inflammation: potential psychogenic pathways to higher C-reactive protein levels. Cytokine 63, 172–178.Google Scholar
Heim, C, Mletzko, T, Purselle, D, Musselman, DL, Nemeroff, CB (2008 a). The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biological Psychiatry 63, 398–405.CrossRefGoogle ScholarPubMed
Heim, C, Nater, UM, Maloney, E, Boneva, R, Jones, JF, Reeves, WC (2009). Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Archives of General Psychiatry 66, 72–80.Google Scholar
Heim, C, Nemeroff, CB (2002). Neurobiology of early life stress: clinical studies. Seminars in Clinical Neuropsychiatry 7, 147–159.CrossRefGoogle ScholarPubMed
Heim, C, Newport, DJ, Bonsall, R, Miller, AH, Nemeroff, CB (2001). Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. American Journal of Psychiatry 158, 575–581.Google Scholar
Heim, C, Newport, DJ, Mletzko, T, Miller, AH, Nemeroff, CB (2008 b). The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33, 693–710.Google Scholar
Heim, C, Wagner, D, Maloney, E, Papanicolaou, DA, Solomon, L, Jones, JF, Unger, ER, Reeves, WC (2006). Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study. Archives of General Psychiatry 63, 1258–1266.Google Scholar
Heins, MJ, Knoop, H, Lobbestael, J, Bleijenberg, G (2011). Childhood maltreatment and the response to cognitive behavior therapy for chronic fatigue syndrome. Journal of Psychosomatic Research 71, 404–410.Google Scholar
Henningsen, P, Zipfel, S, Herzog, W (2007). Management of functional somatic syndromes. Lancet 369, 946–955.Google Scholar
Hepgul, N, Pariante, CM, Dipasquale, S, DiForti, M, Taylor, H, Marques, TR, Morgan, C, Dazzan, P, Murray, RM, Mondelli, V (2012). Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychological Medicine 42, 1893–1901.Google Scholar
Imbierowicz, K, Egle, UT (2003). Childhood adversities in patients with fibromyalgia and somatoform pain disorder. European Journal of Pain 7, 113–119.Google Scholar
Johnson, SK, DeLuca, J, Natelson, BH (1999). Chronic fatigue syndrome: reviewing the research findings. Annals of Behavioral Medicine 21, 258–271.Google Scholar
Johnson, SK, Schmaling, KB, Dmochowski, J, Bernstein, D (2010). An investigation of victimization and the clinical course of chronic fatigue syndrome. Journal of Health Psychology 15, 351–361.Google Scholar
Kawatani, J, Mizuno, K, Shiraishi, S, Takao, M, Joudoi, T, Fukuda, S, Watanabe, Y, Tomoda, A (2011). Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome – a 6-month follow-up study. Brain and Development 33, 832–841.Google Scholar
Kempke, S, Luyten, P, Claes, S, Van Wambeke, P, Bekaert, P, Goossens, L, Van Houdenhove, B (2013). The prevalence and impact of early childhood trauma in chronic fatigue syndrome. Journal of Psychiatric Research 47, 664–669.Google Scholar
Kosseva, M, Schild, S, Wilhelm-Schwenk, R, Biewer, W, Häuser, W (2010). Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings [in German]. Schmerz 24, 474–484.Google Scholar
Kroenke, K, Mangelsdorff, AD (1989). Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome. American Journal of Medicine 86, 262–266.Google Scholar
Lampe, A, Doering, S, Rumpold, G, Solder, E, Krismer, M, Kantner-Rumplmair, W, Schubert, C, Sollner, W (2003). Chronic pain syndromes and their relation to childhood abuse and stressful life events. Journal of Psychosomatic Research 54, 361–367.Google Scholar
Loevinger, BL, Shirtcliff, EA, Muller, D, Alonso, C, Coe, CL (2012). Delineating psychological and biomedical profiles in a heterogeneous fibromyalgia population using cluster analysis. Clinical Rheumatology 31, 677–685.CrossRefGoogle Scholar
Lommel, K, Kapoor, S, Bamford, J, Melguizo, MS, Martin, C, Crofford, L (2009). Juvenile primary fibromyalgia syndrome in an inpatient adolescent psychiatric population. International Journal of Adolescent Medicine and Health 21, 571–579.Google Scholar
Low, LA, Schweinhardt, P (2012). Early life adversity as a risk factor for fibromyalgia in later life. Pain Research and Treatment 2012, 140832.Google Scholar
Lyall, M, Peakman, M, Wessely, S (2003). A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. Journal of Psychosomatic Research 55, 79–90.Google Scholar
Maes, M, Twisk, FN (2010). Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Medicine 8, 35.Google Scholar
Maes, M, Twisk, FNM, Ringel, K (2012). Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression. Psychotherapy and Psychosomatics 81, 286–295.Google Scholar
Malleson, PN, al-Matar, M, Petty, RE (1992). Idiopathic musculoskeletal pain syndromes in children. Journal of Rheumatology 19, 1786–1789.Google ScholarPubMed
Maniglio, R (2009). The impact of child sexual abuse on health: a systematic review of reviews. Clinical Psychology Review 29, 647–657.Google Scholar
Masuda, A, Nozoe, SI, Matsuyama, T, Tanaka, H (1994). Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome. Psychosomatic Medicine 56, 512–518.Google Scholar
May-Chahal, C, Cawson, P (2005). Measuring child maltreatment in the United Kingdom: a study of the prevalence of child abuse and neglect. Child Abuse and Neglect 29, 969–984.CrossRefGoogle ScholarPubMed
McBeth, J, Silman, AJ (2001). The role of psychiatric disorders in fibromyalgia. Current Rheumatology Reports 3, 157–1564.CrossRefGoogle ScholarPubMed
McLean, SA, Williams, DA, Stein, PK, Harris, RE, Lyden, AK, Whalen, G, Park, KM, Liberzon, I, Sen, A, Gracely, RH, Baraniuk, JN, Clauw, DJ (2006). Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. Neuropsychopharmacology 31, 2776–2782.CrossRefGoogle Scholar
Morris, G, Maes, M (2012). Increased nuclear factor-kappaB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Medical Hypotheses 79, 607–613.Google Scholar
NICE (2007). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (or Encephalopathy). Diagnosis and Management of CFS/ME in Adults. National Institute for Health and Clinical Excellence (NICE) Clinical Guidelines No. 53. Royal College of General Practitioners (UK): London.Google Scholar
Nicolson, NA, Davis, MC, Kruszewski, D, Zautra, AJ (2010). Childhood maltreatment and diurnal cortisol patterns in women with chronic pain. Psychosomatic Medicine 72, 471–480.Google Scholar
Okifuji, A, Turk, DC, Sherman, JJ (2000). Evaluation of the relationship between depression and fibromyalgia syndrome: why aren't all patients depressed? Journal of Rheumatology 27, 212–219.Google Scholar
Pace, TW, Mletzko, TC, Alagbe, O, Musselman, DL, Nemeroff, CB, Miller, AH, Heim, CM (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry 163, 1630–1633.CrossRefGoogle ScholarPubMed
Pae, CU, Masand, PS, Marks, DM, Krulewicz, S, Han, CS, Peindl, K, Mannelli, P, Patkar, AA (2009). History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release. World Journal of Biological Psychiatry 10, 435–441.Google Scholar
Pariante, CM (2009). Chronic fatigue syndrome and the immune system: ‘findings in search of meanings’. Brain, Behavior, and Immunity 23, 325–326.Google Scholar
Pariante, CM, Lightman, SL (2008). The HPA axis in major depression: classical theories and new developments. Trends in Neurosciences 31, 464–468.Google Scholar
Pereda, N, Guilera, G, Forns, M, Gomez-Benito, J (2009). The prevalence of child sexual abuse in community and student samples: a meta-analysis. Clinical Psychology Review 29, 328–338.CrossRefGoogle ScholarPubMed
Post, RM, Altshuler, LL, Leverich, GS, Frye, MA, Suppes, T, McElroy, SL, Keck, PE Jr., Nolen, WA, Kupka, RW, Grunze, H, Rowe, M (2013). Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder. Journal of Affective Disorders 147, 288–294.CrossRefGoogle ScholarPubMed
Raison, CL, Lin, JM, Reeves, WC (2009). Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain, Behavior, and Immunity 23, 327–337.CrossRefGoogle Scholar
Reeves, WC, Lloyd, A, Vernon, SD, Klimas, N, Jason, LA, Bleijenberg, G, Evengard, B, White, PD, Nisenbaum, R, Unger, ER (2003). Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Services Research 3, 25.CrossRefGoogle ScholarPubMed
Roberts, AD, Papadopoulos, AS, Wessely, S, Chalder, T, Cleare, AJ (2009). Salivary cortisol output before and after cognitive behavioural therapy for chronic fatigue syndrome. Journal of Affective Disorders 115, 280–286.Google Scholar
Roberts, ADL, Wessely, S, Chalder, T, Papadopoulos, A, Cleare, AJ (2004). Salivary cortisol response to awakening in chronic fatigue syndrome. British Journal of Psychiatry 184, 136–141.Google Scholar
Ruiz-Perez, I, Plazaola-Castano, J, Caliz-Caliz, R, Rodriguez-Calvo, I, Garcia-Sanchez, A, Ferrer-Gonzalez, MA, Guzman-Ubeda, M, del Rio-Lozano, M, Lopez-Chicheri, Garcia I (2009). Risk factors for fibromyalgia: the role of violence against women. Clinical Rheumatology 28, 777–786.Google Scholar
Sanders, P, Korf, J (2008). Neuroaetiology of chronic fatigue syndrome: an overview. World Journal of Biological Psychiatry 9, 165–171.Google Scholar
Sareen, J, Henriksen, CA, Bolton, SL, Afifi, TO, Stein, MB, Asmundson, GJ (2013). Adverse childhood experiences in relation to mood and anxiety disorders in a population-based sample of active military personnel. Psychological Medicine 43, 73–84.Google Scholar
Sigurdardottir, S, Halldorsdottir, S (2013). Repressed and silent suffering: consequences of childhood sexual abuse for women's health and well-being. Scandinavian Journal of Caring Sciences 27, 422–432.Google Scholar
Smith, BW, Papp, ZZ, Tooley, EM, Montague, EQ, Robinson, AE, Cosper, CJ (2010). Traumatic events, perceived stress and health in women with fibromyalgia and healthy controls. Stress and Health 26, 83–93.CrossRefGoogle Scholar
Solomon, L, Nisenbaum, R, Reyes, M, Papanicolaou, DA, Reeves, WC (2003). Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population. Health and Quality of Life Outcomes 1, 48.CrossRefGoogle ScholarPubMed
Sommer, C, Häuser, W, Burgmer, M, Engelhardt, R, Gerhold, K, Petzke, F, Schmidt-Wilcke, T, Spath, M, Tolle, T, Uceyler, N, Wang, H, Winkelmann, A, Thieme, K (2012). Etiology and pathophysiology of fibromyalgia syndrome [in German]. Schmerz 26, 259–267.Google Scholar
Strickland, P, Morriss, R, Wearden, A, Deakin, B (1998). A comparison of salivary cortisol in chronic fatigue syndrome, community depression and healthy controls. Journal of Affective Disorders 47, 191–194.Google Scholar
Susman, EJ (2006). Psychobiology of persistent antisocial behavior: stress, early vulnerabilities and the attenuation hypothesis. Neuroscience and Biobehavioural Reviews 30, 376–389.Google Scholar
Taylor, RR, Jason, LA (2001). Sexual abuse, physical abuse, chronic fatigue, and chronic fatigue syndrome: a community-based study. Journal of Nervous and Mental Disease 189, 709–715.Google Scholar
Tietjen, GE, Brandes, JL, Peterlin, BL, Eloff, A, Dafer, RM, Stein, MR, Drexler, E, Martin, VT, Hutchinson, S, Aurora, SK, Recober, A, Herial, NA, Utley, C, White, L, Khuder, SA (2010). Childhood maltreatment and migraine (Part III). Association with comorbid pain conditions. Headache 50, 42–51.Google Scholar
Van Houdenhove, B, Egle, U, Luyten, P (2005). The role of life stress in fibromyalgia. Current Rheumatology Reports 7, 365–370.CrossRefGoogle ScholarPubMed
Van Houdenhove, B, Neerinckx, E, Lysens, R, Vertommen, H, Van Houdenhove, L, Onghena, P, Westhovens, R, D'Hooghe, MB (2001). Victimization in chronic fatigue syndrome and fibromyalgia in tertiary care: a controlled study on prevalence and characteristics. Psychosomatics 42, 21–28.Google Scholar
Walen, HR, Oliver, K, Groessl, E, Cronan, TA, Rodriguez, VM (2001). Traumatic events, health outcomes, and health care use in patients with fibromyalgia. Journal of Muscoloskeletal Pain 9, 19–38.Google Scholar
Walker, EA, Keegan, D, Gardner, G, Sullivan, M, Bernstein, D, Katon, WJ (1997). Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect. Psychosomatic Medicine 59, 572–577.Google Scholar
Wallace, DJ (2006). Is there a role for cytokine based therapies in fibromyalgia. Current Pharmaceutical Design 12, 17–22.Google Scholar
Weissbecker, I, Floyd, A, Dedert, E, Salmon, P, Sephton, S (2006). Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome. Psychoneuroendocrinology 31, 312–324.Google Scholar
Wessely, S (1998). The epidemiology of chronic fatigue syndrome. Epidemiologia e Psichiatria Sociale 7, 10–24.Google Scholar
Wessely, S, Powell, R (1989). Fatigue syndromes: a comparison of chronic ‘postviral’ fatigue with neuromuscular and affective disorders. Journal of Neurology, Neurosurgery and Psychiatry 52, 940–948.Google Scholar
Wolfe, F (1997). The relation between tender points and fibromyalgia symptom variables: evidence that fibromyalgia is not a discrete disorder in the clinic. Annals of the Rheumatic Diseases 56, 268–271.CrossRefGoogle Scholar