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X.—The Pigmentary System and the Dopa Reaction

Published online by Cambridge University Press:  15 September 2014

Evlyn Boyd
Evlyn Boyd
Affiliation:
University of South Africa
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Summary

1. A description of the mammalian pigmentary system is given together with an outline of the mechanism of melanin production and those factors which influence or control it.

2. The production of melanin by chemicophysical interaction between circulating 3-4-dihydroxyphenylalanine (dopa) in the blood-stream and an enzyme or enzymes of intracellular origin is accepted, but it is emphasised that in the interaction there are numerous opportunities for physiological interference which inhibit melanin formation.

3. The current theories of the origin of melanin are discussed and evidence supporting the nuclear origin of oxidising enzymes is given.

4. It is suggested that in the sheep some epidermal cells are more potentially pigment-producing than others, and that a gradation exists between the cell which cannot produce pigment and that which produces it to a maximum degree.

5. It is postulated that only one pigment exists, and that all animal colours are the result of a modification of this one pigment.

6. The results of staining sections of lamb and adult sheep skin with dopa are given.

7. A series of in vitro experiments planned to standardise the dopa reaction is described.

8. It is suggested that the dopa reaction may be used as a simple chemical test in genetic analysis whereby the pigmentogenic potentialities of a particular sheep may be analysed.

Type
Proceedings
Information
Proceedings of the Royal Society of Edinburgh , Volume 52 , 1933 , pp. 218 - 235
Copyright
Copyright © Royal Society of Edinburgh 1933

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References

BIBLIOGRAPHY

Bloch, B., 1917. “Chemische Untersuchungen über das spezifische pigmentbildende Fermente der Haut, die Dopaoxydase,” Ztschr. f. physiol. Chemie, 98.Google Scholar
Bloch, B., 1917. “Das Problem der Pigmentbildung,” Arch. f. Dermat. u. Syphil., 145, pp. 130–208.Google Scholar
Boyd, E., 1930. “Colour Banding in Fleeces,” Joum. Text. Instit., 21, 6.Google Scholar
Boyd, E., 1931. Pigmentation in Fibres of the Suffolk Breed of Sheep. (In Press.)Google Scholar
Esskuchen, E., 1927. “Über die Entstehung der Farbung der Haussaugetiere,” Zuchtungskunde, 2, Heft 27.Google Scholar
Gortner, R. A., 1911. “Studies on Melanin,” Journ. Biol. Chem. 10, p. 113.Google Scholar
Hadwen, S., 1929. “Colour Changes in Lepas Americanus and other Animals,” Canad. Journ. of Res., 1, 2, pp. 189–200.Google Scholar
Haugg, R., 1926. “Über das Pigment des einfarbig graubraunen Gebirgsviehes,” Zuchtungskunde, Band 1.Google Scholar
Hausman, L. A., 1928. “The Pigment Granules of Human Head Hair: A Comparative Racial Study,” Amer. Journ. Phys. Anthrop., 12, 2, pp. 273–293.Google Scholar
Jeliaskowa-Paspalewa, A., 1930. “Cytologische Untersuchungen über die Entstehung des melanotischen Pigments,” Z. Zool., 137, pp. 365–402.Google Scholar
Kermack, W. O., and Voge, C. I. B., 1924-1925. “The Action of Salts with Multivalent Cations on Colloidal Solutions of Gold and Gum Benzoin,” Proc. Roy. Soc. Edin., 45, pp. 90–101.Google Scholar
Koller, P. C, 1929. “Experimental Studies on Pigment Formation,” Archiv für experimentelle Zellforschung, 8, pp. 490–498.Google Scholar
Koller, P. C., 1930. “On Pigment Formation in the D-Black Rabbit,” Journ. of Genet., 22, 1, pp. 103–107.Google Scholar
Little, C. C., 1913. “Inheritance of Colour in Mice,” Carnegie Institution, No. 179, pp. 17–102.Google Scholar
Ludford, R. J., 1924. “Nuclear Activity during Melanosis : With Special Reference to Melanin Formation in a Melanotic Sarcoma,” Journ. Roy. Micr. Soc., pp. 13–28.CrossRefGoogle Scholar
Makarov, P., 1929. “Studien über die Pigmentogenese. Über den Anteil der Mitochondrien an der Bildung des Melanins in den Zellen des Pigmentsepithels der Retina,” Russk. Arch. Anat., 8, pp. 255–278. [In Russian.]Google Scholar
Miescher, G., 1923. “Die Pigmentgenese im Auge nebst Bermerkungen über die Natur des Pigmentkorns,” Arch. mikr. Anat., 97, pp. 326–369.Google Scholar
Moncrieff, R. Scott, 1931. “The Chemical Effect of a Mendelian Factor for Flower Colour,” Nature, 127, No. 3217, p. 974.Google Scholar
Percival, G. H., and Stewart, C. P., 1930. “Melanogenesis : A Review,” Edin. Med. Journ., Sept., pp. 497–523.Google Scholar
Pryde, J., 1928. Recent Advances in Biochemistry. London : J. & A. Churchill. 8vo. Pp. x + 379.Google Scholar
Przibram, H. (Unter Mitwirkung von Dembowski, J., und Brecher, L.), 1921. “Einwirkung der Tyrosinase auf Dopa—Zugleich : Uraschen tierischer Farbkleidung. IV,” Arch. f. Entw.-Mech., 48, pp. 140–165.CrossRefGoogle Scholar
Raper, H. S., 1926. “The Tyrosinase-Tyrosine Reaction. Production of Dihydroxyphenylalanine from Tyrosine,” Biochem. Journ., 21, p. 735.Google Scholar
Ridgway, Robert, 1886. Nomenclature of Colors. Boston: Little, Brown & Company.Google Scholar
Roberts, J. A. Fraser, 1924. “Colour Inheritance in Sheep. I.—Black Colour and Badger-face Pattern in Welsh Mountain Sheep,” Journ. of Genet., 14, pp. 367- 374.CrossRefGoogle Scholar
Roberts, J. A. Fraser, 1926. “Colour Inheritance in Sheep. II.—The Piebald Pattern of the Piebald Breed,” Journ. of Genet., 17, pp. 77–84.Google Scholar
Roberts, J. A. Fraser, 1926. “Piebald (Spanish) Sheep and their Crosses with other Breeds,” Welsh Journ. of Agric., 2, pp. 66–69.Google Scholar
Roberts, J. A. Fraser, 1927. “The Inheritance of Some Colours and Patterns in Sheep,” Journ. Text. Inst., 18.Google Scholar
Roberts, J. A. Fraser, 1928. “Colour Inheritance in Sheep. III.—Face and Leg Colour,” Journ. of Genet., 19, pp. 261–268.Google Scholar
Roberts, J. A. Fraser, and White, R. G., 1930. “Colour Inheritance in Sheep. IV.—White Colour, Recessive Black Colour, Recessive Brown Colour, Badger-face Pattern, and Reversed Badger-face Pattern,” Journ. of Genet., 22, pp. 165–180.Google Scholar
Roberts, J. A. Fraser, and White, R. G., 1930. “Colour Inheritance in Sheep. V.—Dominant Black,” Journ. of Genet., 22, pp. 181–190.CrossRefGoogle Scholar
Teodoreanu, N. I., 1930. “Histo-Ethnologische Untersuchungen über die Struktur der Haut bei Mangalicza—und Lincolnshire—Schweinen,” Bull. Sect. Sci. Acad. Rouman., 13, 19 pp.Google Scholar
Wassin, B., 1928. “The Genetics of the Sheep I.—Inheritance of Colour and Pattern,” Trans. Gentr. Stat. Genet. Farm Animals, No. 2, p. 67.Google Scholar
Wright, Sewall, 1917. “Color Inheritance in Mammals,” Journ. of Hered., 8, pp. 224–235.Google Scholar
Wright, Sewall, 1917. “Color Inheritance in Mammals. II.—The Mouse,” Journ. of Hered., 8, pp. 373–378.CrossRefGoogle Scholar
Wright, Sewall, 1917. “Color Inheritance in Mammals. VI.—Cattle,” Journ. of Hered., 8, pp. 521–527.CrossRefGoogle Scholar
Wright, Sewall, 1917. “Color Inheritance in Mammals. VII.—The Horse,” Journ. of Hered., 8, pp. 561–564.Google Scholar
Wright, Sewall, 1918. “Color Inheritance in Mammals. XI.—Man,” Journ. of Hered., 20, pp. 227–240.Google Scholar