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Silicon Nanotechnology for Biofiltration and Immunoisolated Cell Xenografts

Published online by Cambridge University Press:  15 February 2011

M. Ferrari ,
IW. Chu ,
IT. Desai ,
D. Hansford ,
G. Mazzoni ,
T. Huen  and
M. Zhang
M. Ferrari
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
IW. Chu
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
IT. Desai
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
D. Hansford
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
G. Mazzoni
Affiliation:
Microsurgical Institute, Mercy Hospital, San Diego, CA 92103
T. Huen
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
M. Zhang
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
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Abstract

Silicon-based clean-room technology is employed for the microfabrication of a particle filter with uniform pore dimensions in the 20-40-nm range. Surface and bulk micromachining are integrated in the fabrication process, resulting in a filtering membrane with large active area, flow rate and resistance to pressure. The microfabricated membrane is especially suitable for biofluid purification, including viral elimination. The nanofilter is a technological precursor for a microfabricated, silicon-based capsule to be employed in the reaction-free xenotransplantation of cells. Results are presented below that address the issue of biocompatibility of the microfabricated capsule components and materials.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 414: Symposium Z – Thin Films and Surfaces for Bioactivity and Biomedical Applications , 1995 , 101
Copyright
Copyright © Materials Research Society 1996

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References

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