Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-12T22:15:24.082Z Has data issue: false hasContentIssue false
  • English
  • Français

Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

Published online by Cambridge University Press:  01 February 2011

Zhan Liu ,
David G. Bucknall  and
Mark G. Allen
Zhan Liu
Affiliation:
gth825n@mail.gatech.edu, Georgia Institute of Technology, School of Polymer, Textile, and Fiber Engineering, Atlanta, Georgia, United States
David G. Bucknall
Affiliation:
david.bucknall@ptfe.gatech.edu, Georgia Institute of Technology, School of Polymer, Textile, and Fiber Engineering, Atlanta, Georgia, United States
Mark G. Allen
Affiliation:
mallen@gatech.edu, Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, Georgia, United States
Get access

Abstract

This work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

Keywords

polymernanoscalebiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1138: Symposium FF – Nanofunctional Materials, Structures and Devices for Biomedical Applications , 2008 , 1138-FF09-13
Copyright
Copyright © Materials Research Society 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Weisbord, S. D., Reviews in Cardiovascular Medicine. 9, S14 (2008).Google Scholar
2. Mosbach, K. and Ramstrom, O., Biotechnology, 14, 163 (1996).Google Scholar
3. Haupt, K., Dzgoev, A., and Mosbach, K., Anal. Chem. 70, 628 (1998).Google Scholar
4. Bergmann, N. M. and Peppas, N. A., Progress in Polymer Science, 33, 271 (2008).Google Scholar
5. Ye, L. and Mosbach, K., Journal of Inclusion Phenomena and Macrocyclic Chemistry, 41, 107 (2001).Google Scholar
6. Jacobsen, P. B., Larsen, A., Konarboland, R., and Skotland, T., Drug Metabolism and Disposition, 27, 1205 (1999).Google Scholar
7. Wizeman, W. J., Kofinas, P., Biomaterials, 22, 1485 (2001).Google Scholar
8. Bromberg, L. E. and Klibanov, A. M., Proceedings of the National Academy of Sciences of the United States of America, 92, 1262 (1995).Google Scholar