Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-18T21:56:04.590Z Has data issue: false hasContentIssue false
  • English
  • Français

Mineralization of Multilayer Hydrogels as a Model for Mineralization of Bone

Published online by Cambridge University Press:  15 February 2011

Paul Calvert ,
Joelle Frechette  and
Chad Souvignier
Paul Calvert
Affiliation:
Department of Materials Science and Engineering, University of Arizona, Tucson, AZ, 85712
Joelle Frechette
Affiliation:
Department of Materials Science and Engineering, University of Arizona, Tucson, AZ, 85712
Chad Souvignier
Affiliation:
Department of Materials Science and Engineering, University of Arizona, Tucson, AZ, 85712
Get access

Abstract

Extrusion freeform fabrication is a 3-D layerwise writing technique for forming objects directly under the control of a CAD program. This method is one of a family of rapid prototyping methods which include stereolithography, selective laser sintering and fused deposition modeling. This system can be used to build shapes, layer by layer, from hydrogels of agarose, polyacrylamide or other cross-linked water-soluble acrylic polymers.

Mineralization can be induced in these gels by building a part with alternating layers of gels containing calcium and carbonate or phosphate that can be formed into stacks which then mineralize by cross-diffusion. The write head can be conceived of as a cell which delivers the appropriate minerals to a site within a swollen gel matrix. This diffusive mineralization process can thus be compared with bone mineralization. The gel structure controls the morphology of the mineral. The site of mineralization is controlled by osmotic forces which localize most of the mineral in whichever zone has the higher ionic strength. The mineral content, expressed as a fraction of the polymer content, is similar to that of bone but the water content is much higher than in bone. This raises the question of what process drives the water exclusion during bone mineralization.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 489: Symposium K – Materials Science of the Cell , 1997 , 153
Copyright
Copyright © Materials Research Society 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lowenstam, H. A. and Weiner, S. On Biomineralization (Oxford University Press, Oxford, 1989).Google Scholar
2. Henisch, H. K. Crystals in gels and Liesegang rings : in vitro veritas. (Cambridge University Press, Cambridge, 1988).Google Scholar
3. Garciaruiz, J. M. and Moreno, A. “Growth Behaviour of Twisted Ribbons of Barium Carbonate/silica Self-assembled Ceramics”, Anales de Quimica 93, 1–2, 1997.Google Scholar
4. Calvert, P. “Biomimetic Ceramics and Hard Composites” in Biomimetics (eds. Sarikaya, M. & Aksay, I.A.) (AIP Press, Woodbury, NY, 1995) pp. 145–161.Google Scholar
5. Burdon, J., Szmania, J. and Calvert, P. “Organic-Inorganic Hybrids with a Crystalline Polymer Matrix” in Am. Chem. Soc. Symposia 585, 6–18, 1995.Google Scholar
6. Burdon, J. and Calvert, P. “Control of Particle Size and Orientation during In situ Precipitation of Oxides in Polymers”, Materials Research Society Symposium Proceedings 286, 315–320, 1993.Google Scholar
7. Burdon, J. and Calvert, P. D. “Orientation in Biomimetic Polymer-Mineral Composites” in MRS Symposium Hierarchically Structured Materials (eds. Aksay, I., Baer, E., Sarikaya, M. & Tirrell, D.A.) (Materials Research Society, Pittsburgh, PA, 1992) pp.375–383.Google Scholar
8. Calvert, P. and Crockett, R. “Chemical solid free-form fabrication: making shapes without molds”, Chem. Mater. 9, 650–663, 1997.Google Scholar
9. Glimcher, M. J. “Molecular biology of mineralized tissues with particular reference to bone” in Biophysical Scienc e- A study program (Also Rev. Modern Phys. Jan. & April 1959) (eds. Oncley, J.L.) (J. Wiley & Sons, New York, 1959) pp.359–393.Google Scholar