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Fructose-Enhanced Efficacy of Magnetic Nanoparticles against Antibiotic Resistant Biofilms

Published online by Cambridge University Press:  23 January 2013

N. Gozde Durmus ,
Erik N. Taylor  and
Thomas J. Webster
N. Gozde Durmus
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Erik N. Taylor
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912 Department of Chemical Engineering, Northeastern University, Boston, MA, USA 02215
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Abstract

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections (HAI). HAI affect approximately 1.7 million patients each year in the U.S., resulting in up to 100,000 excess deaths, which leads to an estimated cost of more than $35 billion per year. Hence, there is an urgent clinical need to develop new therapies to reduce infections, without resorting to the use of antibiotics for which bacteria are developing a resistance towards. In this study, we designed superparamagnetic iron-oxide nanoparticles (SPION) to treat antibiotic-resistant biofilms and showed that SPION efficacy increases when they are used in combination with fructose.

Keywords

nanoscalebiomaterialmagnetic
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1498: Symposium L – Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications , 2013 , pp. 133 - 138
Copyright
Copyright © Materials Research Society 2013 

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