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Fructose-Enhanced Efficacy of Magnetic Nanoparticles against Antibiotic Resistant Biofilms

  • N. Gozde Durmus (a1), Erik N. Taylor (a1) and Thomas J. Webster (a1) (a2)

Abstract

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections (HAI). HAI affect approximately 1.7 million patients each year in the U.S., resulting in up to 100,000 excess deaths, which leads to an estimated cost of more than $35 billion per year. Hence, there is an urgent clinical need to develop new therapies to reduce infections, without resorting to the use of antibiotics for which bacteria are developing a resistance towards. In this study, we designed superparamagnetic iron-oxide nanoparticles (SPION) to treat antibiotic-resistant biofilms and showed that SPION efficacy increases when they are used in combination with fructose.

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Fructose-Enhanced Efficacy of Magnetic Nanoparticles against Antibiotic Resistant Biofilms

  • N. Gozde Durmus (a1), Erik N. Taylor (a1) and Thomas J. Webster (a1) (a2)

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