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Fructose-Enhanced Efficacy of Magnetic Nanoparticles against Antibiotic Resistant Biofilms

Published online by Cambridge University Press:  23 January 2013

N. Gozde Durmus ,
Erik N. Taylor  and
Thomas J. Webster
N. Gozde Durmus
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Erik N. Taylor
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912 Department of Chemical Engineering, Northeastern University, Boston, MA, USA 02215
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Abstract

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections (HAI). HAI affect approximately 1.7 million patients each year in the U.S., resulting in up to 100,000 excess deaths, which leads to an estimated cost of more than $35 billion per year. Hence, there is an urgent clinical need to develop new therapies to reduce infections, without resorting to the use of antibiotics for which bacteria are developing a resistance towards. In this study, we designed superparamagnetic iron-oxide nanoparticles (SPION) to treat antibiotic-resistant biofilms and showed that SPION efficacy increases when they are used in combination with fructose.

Keywords

nanoscalebiomaterialmagnetic
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1498: Symposium L – Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications , 2013 , pp. 133 - 138
Copyright
Copyright © Materials Research Society 2013 

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References

REFERENCES

O'Toole, G., Kaplan, H. B., and Kolter, R., “Biofilm formation as microbial development,” Annual Review of Microbiology, vol. 54, pp. 49–79, 2000.CrossRefGoogle Scholar
Hall-Stoodley, L., Costerton, J. W., and Stoodley, P., “Bacterial biofilms: From the natural environment to infectious diseases,” Nature Reviews Microbiology, vol. 2, pp. 95–108, Feb 2004.CrossRefGoogle Scholar
Xavier, JB, Picioreanu, C, Rani, SA, van Loosdrecht, MC, and Stewart, PS., “Biofilm-control strategies based on enzymic disruption of the extracellular polymeric substance matrix-a modelling study.,” Microbiology, vol. 151, pp. 3817–32., 2005.CrossRefGoogle Scholar
Davey, ME and O'toole, GA., “Microbial biofilms: from ecology to molecular genetics,” Microbiol Mol Biol Rev., vol. 64, pp. 847–67, 2000.CrossRefGoogle Scholar
Antoci, V Jr, Adams, CS, Parvizi, J, Davidson, HM, Composto, RJ, Freeman, TA, Wickstrom, E, Ducheyne, P, Jungkind, D, Shapiro, IM, and Hickok, NJ, “The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection.,” Biomaterials, vol. 35, pp. 4684–90, 2008.CrossRefGoogle Scholar
Davies, D. G., Chakrabarty, A. M., and Geesey, G. G., “EXOPOLYSACCHARIDE PRODUCTION IN BIOFILMS - SUBSTRATUM ACTIVATION OF ALGINATE GENE-EXPRESSION BY PSEUDOMONAS-AERUGINOSA,” Applied and Environmental Microbiology, vol. 59, pp. 1181–1186, Apr 1993.Google Scholar
Costerton, JW, Stewart, PS, and Greenberg, EP., “Bacterial biofilms: a common cause of persistent infections.,” Science, vol. 284, pp. 1318–22., 1999.CrossRefGoogle Scholar
Hao, R., Xing, R. J., Xu, Z. C., Hou, Y. L., Gao, S., and Sun, S. H., “Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles,” Advanced Materials, vol. 22, pp. 2729–2742, Jul 2010.CrossRefGoogle Scholar
Tran, N., Mir, A., Mallik, D., Sinha, A., Nayar, S., and Webster, T. J., “Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus,” International Journal of Nanomedicine, vol. 5, pp. 277–283, 2010.Google Scholar
Lee, D., Cohen, R. E., and Rubner, M. F., “Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticles,” Langmuir, vol. 21, pp. 9651–9659, Oct 2005.CrossRefGoogle Scholar
Taylor, E. N. and Webster, T. J., “The use of superparamagnetic nanoparticles for prosthetic biofilm prevention,” International Journal of Nanomedicine, vol. 4, pp. 145–152, 2009.Google Scholar
Park, H., Park, H. J., Kim, J. A., Lee, S. H., Kim, J. H., Yoon, J., and Park, T. H., “Inactivation of Pseudomonas aeruginosa PA01 biofilms by hyperthermia using superparamagnetic nanoparticles,” Journal of Microbiological Methods, vol. 84, pp. 41–45, Jan 2011.CrossRefGoogle Scholar
Allison, KR, Brynildsen, MP, and Collins, JJ., “Metabolite-enabled eradication of bacterial persisters by aminoglycosides,” Nature, vol. 73, pp. 216–20, 2011.CrossRefGoogle Scholar
Wan, J., Cai, W., Meng, X., and Liu, E., “Monodisperse water-soluble magnetite nanoparticles prepared by polyol process for high-performance magnetic resonance imaging,” Chemical Communications, pp. 5004–5006, 2007.CrossRefGoogle Scholar
Yantasee, W., Warner, C. L., Sangvanich, T., Addleman, R. S., Carter, T. G., Wiacek, R. J., Fryxell, G. E., Timchalk, C., and Warner, M. G., “Removal of heavy metals from aqueous systems with thiol functionalized superparamagnetic nanoparticles,” Environmental Science & Technology, vol. 41, pp. 5114–5119, Jul2007.CrossRefGoogle Scholar
Murdock, R. C., Braydich-Stolle, L., Schrand, A. M., Schlager, J. J., and Hussain, S. M., “Characterization of nanomaterial dispersion in solution prior to In vitro exposure using dynamic light scattering technique,” Toxicological Sciences, vol. 101, pp. 239–253, Feb 2008.CrossRefGoogle Scholar
Durmus, NG and Webster, TJ, “Eradicating Antibiotic-Resistant Biofilms with Silver-Conjugated Superparamagnetic Iron Oxide Nanoparticles,” Advanced Healthcare Materials, 2012.Google Scholar
Dobrovolskaia, M. A., Patri, A. K., Zheng, J. W., Clogston, J. D., Ayub, N., Aggarwal, P., Neun, B. W., Hall, J. B., and McNeil, S. E., “Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles,” Nanomedicine-Nanotechnology Biology and Medicine, vol. 5, pp. 106–117, Jun 2009.CrossRefGoogle Scholar