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Design and Analysis of Microcantilevers for Biosensing Applications

Published online by Cambridge University Press:  11 February 2011

Xuan Zhang ,
Mo Yang  and
Cengiz S. Ozkan
Xuan Zhang
Affiliation:
Mechanical Engineering Department, University of California, Riverside, CA 92521
Mo Yang
Affiliation:
Mechanical Engineering Department, University of California, Riverside, CA 92521
Cengiz S. Ozkan
Affiliation:
Mechanical Engineering Department, University of California, Riverside, CA 92521
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Abstract

The primary deflection due to the chemical reaction between the analyte molecules and the receptor coating, which produces surface stresses on the receptor side is analyzed. The resonance frequency of microcantilevers is very sensitive to the properties of the microcantilever surface. Biosensing experiments based on resonance frequency shift are presented, which show that the results strongly depend on the interaction of specific analyte molecules with the receptor surface.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 738: Symposium G – Spatially Resolved Characterization of Local Phenomena in Materials and Nanostructures , 2002 , G13.15
Copyright
Copyright © Materials Research Society 2003

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References

REFERENCES

Lavrik, N. V., Tipple, C. A., Sepaniak, M. J. and Datskos, D., Gold Nano-Structure for Transduction of Biomolecular Interactions into Micrometer Scale Movements, Biomedical Microdevices, 3:1, 2001, 35–44.Google Scholar
2. Lu, P., Shen, F., O'shea, S. J., Lee, K.H. and Ng, T.Y., Analysis of Surface Effects on Mechanical Properties of Microcantilevers, Mater. Phys. Mench. 4, 2001, 51–55.Google Scholar
3. Moulin, A. M., O'Shea, S. J. and Welland, M. E., Microcantilever-based Biosensors, Ultramicroscopy, 82, 2000, 23–31.Google Scholar
4. Piezoelectric Technology Data for Designers, Morgan Matroc Inc., Electro Ceramics Division., 2000, p.14.Google Scholar
5. Madou, Marc, “Fundamentals of Microfabrication”, CRC Press, 1997.Google Scholar
6. Pritchard, W. F., Davis, P. F., Derafshi, Z., Polacek, D. C., Tsoa, R., Dull, R. O., Jones, S. A. and Giddens, D. P., Effects of Wall Shear Stress and Fluid Recirculation on the Localization of circulating Monocytes in a Three Dimensional flow model, J. of Biomechanics, 28, 1995, 1459–1469.Google Scholar
7. Raiteri, R. and Nelles, G., Butt, H. -J., Knoll, W. and Skladal, P., Sensing of Biological Substances Based on the Bending of the Microfabricated Cantilevers, Sensors and Actuators B, 61, 1999, 213–217.Google Scholar
8. Ramakrishnan, A. and Sadana, A., A Predictive Approach using Fractal Analysis for Analyte-Receptor Binding and Dissociation Kinetics for Surface Plasmon Resonance Biosensor Applications, J. of interface and Colloid Science, 229, 2000, 628–640.Google Scholar
9. Swift, D. G., Posner, R. G., and Hammer, D. A., Kinetics of Adhesion of IgE-Sensitized Rat Basophilic Leukemia Cells to Surface-Immobilized Antigen in Couette Flow, Biophysical Journal, 75, 1998, 2597–2611.Google Scholar
10. Ulman, A., Formation and Structure of Self Asswmbled Monolayers, Chem. Rev., 96, 1996, 1533–1554.Google Scholar
11. Vo-Dinh, T., Cullum, B. M., Stokes, D. L., Nanosensors and Biochips: Frontiers in Biomolecular Diagnostics, Sensors and Actuators B, 74, 2001, 2–11.Google Scholar
12. Wu, G., Ji, H., Hansen, K., Thundat, T., Datar, R., Cote, R., Hagan, M. F., Chakraborty, A. K., and Majumdar, A., Origin of Nanomechanical Cantilever Motion Generated from Biomolecular Interactions, PNAS, 98, 2001, 1560–1564.Google Scholar
13. Khaled, A. -R. A., Vafai, K., Ozkan, C. S., Yang, M. and Zhang, X., “Analysis, Control and Augmentation of Microcantilever Deflections in Bio-Sensing Systems”, Journal of Sensors and Actuators, B (submitted).Google Scholar
14. Yang, Mo, Zhang, Xuan and Ozkan, Cengiz S., “Modeling and Optimal Design of Piezoresistive Cantilevers for Biosensing Applications” Journal of Biomedical Microdevices (submitted).Google Scholar