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Size-Tunable Magnetofluorescent Nanoparticles as In Vivo Imaging

Published online by Cambridge University Press:  29 April 2014

Keisuke Sato
Affiliation:
Department of Electrical and Electronic Engineering, Tokyo Denki University, 5 Senju-Asahi-cho, Adachi-ku, Tokyo 120-8551, JAPAN. International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, JAPAN.
Kenji Hirakuri
Affiliation:
Department of Electrical and Electronic Engineering, Tokyo Denki University, 5 Senju-Asahi-cho, Adachi-ku, Tokyo 120-8551, JAPAN.
Kouki Fujioka
Affiliation:
Department of Molecular Cell Biology, Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, JAPAN.
Yoshinobu Manome
Affiliation:
Department of Molecular Cell Biology, Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, JAPAN.
Hiroaki Sukegawa
Affiliation:
Magnetic Materials Center, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, JAPAN.
Hideo Iwai
Affiliation:
Materials Analysis Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, JAPAN.
Naoki Fukata
Affiliation:
International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, JAPAN.
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Abstract

Magnetic/fluorescent (magnetofluorescent) materials have become one of the most important tools in the imaging modality in vivo using magnetic resonance imaging (MRI) and fluorescence imaging. We succeeded in fabricating magnetofluorescent nanoparticles (MFNPs) consisting of silicon/magnetite composite nanoparticles. Our unique synthetic approach can control simultaneously the magnetic and fluorescence behaviors by varying the particle size, demonstrating the superparamagnetic behavior and green fluorescence for the MFNPs having mean diameter of 3.0 nm, and the ferromagnetic behavior without fluorescence for the MFNPs having mean diameter more than 5.0 nm. More intriguingly, the MFNPs with superparamagnetism can detect green fluorescence even after the magnetic guidance of MFNPs by the commercial neodymium magnet. Additionally, the MFNPs having two magnetic behaviors also possess good biocompatibility.

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Articles
Copyright
Copyright © Materials Research Society 2014 

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References

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