Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-26T22:41:48.205Z Has data issue: false hasContentIssue false
  • English
  • Français

The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps

Published online by Cambridge University Press:  15 August 2017

Q L Zhao ,
L Yu ,
L L Zhi ,
P Jin ,
X X Zi ,
L Zhao ,
A Li ,
Y Y Tu ,
L Shi  and
H P Zhang
Q L Zhao
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China Department of Otolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong, China
L Yu
Affiliation:
Department of Otolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong, China
L L Zhi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China Department of Otolaryngology, Central Hospital of Zibo, Shandong, China
P Jin
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
X X Zi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
L Zhao
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
A Li
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
Y Y Tu
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
L Shi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
H P Zhang*
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
*
Address for correspondence: Dr Hong Ping Zhang, Department of Otolaryngology, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, PR China Fax: +86 531 8896 2544 E-mail: tydzhp@sohu.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features.

Methods:

The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling.

Results:

Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (p < 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity.

Conclusion:

Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.

Keywords

Nasal PolypsRespiratory Function TestsAirway RemodelingEosinophilsChinese
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 10 , October 2017 , pp. 880 - 888
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:1–12 CrossRefGoogle ScholarPubMed
2 Kim, JW, Hong, SL, Kim, YK, Lee, CH, Min, YG, Rhee, CS. Histological and immunological features of non-eosinophilic nasal polyps. Otolaryngol Head Neck Surg 2007;137:925–30Google Scholar
3 Li, CW, Zhang, KK, Li, TY, Lin, ZB, Li, YY, Curotto de Lafaille, MA et al. Expression profiles of regulatory and helper T-cell-associated genes in nasal polyposis. Allergy 2012;67:732–40Google Scholar
4 Baba, S, Kagoya, R, Kondo, K, Suzukawa, M, Ohta, K, Yamasoba, T. T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients. Allergy Asthma Clin Immunol 2015;11:33 Google Scholar
5 Gao, T, Ng, CL, Li, C, Li, YY, Duan, C, Shen, L et al. Smoking is an independent association of squamous metaplasia in Chinese nasal polyps. Int Forum Allergy Rhinol 2016;6:66–74 Google Scholar
6 Brozek, JL, Bousquet, J, Baena-Cagnani, CE, Bonini, S, Canonica, GW, Casale, TB et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466–76Google Scholar
7 Kariya, S, Okano, M, Oto, T, Higaki, T, Makihara, S, Haruna, T et al. Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis. J Laryngol Otol 2014;128:255–62CrossRefGoogle ScholarPubMed
8 Kariya, S, Okano, M, Higaki, T, Noyama, Y, Haruna, T, Ishihara, H et al. Chronic rhinosinusitis patients have decreased lung function. Int Forum Allergy Rhinol 2014;4:828–33Google Scholar
9 Yang, MS, Lee, HS, Kim, MH, Song, WJ, Kim, TW, Kwon, JW et al. Rhinitis patients with sputum eosinophilia show decreased lung function in the absence of airway hyperresponsiveness. Allergy Asthma Immunol Res 2013;5:232–8CrossRefGoogle ScholarPubMed
10 Alatas, N, Baba, F, San, I, Kurcer, Z. Nasal polyp diseases in allergic and nonallergic patients and steroid therapy. Otolaryngol Head Neck Surg 2006;135:236–42Google Scholar
11 Soler, ZM, Sauer, DA, Mace, J, Smith, TL. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2009;141:454–61CrossRefGoogle ScholarPubMed
12 Lee, JJ, Jacobsen, EA, McGarry, MP, Schleimer, RP, Lee, NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy 2010;40:563–75Google Scholar
13 Kariya, S, Okano, M, Higaki, T, Noyama, Y, Haruna, T, Nishizaki, K. Pulmonary function in never-smoker patients with chronic rhinosinusitis. Int Forum Allergy Rhinol 2015;5:990–5Google Scholar
14 Lapperre, TS, Sont, JK, van Schadewijk, A, Gosman, MM, Postma, DS, Bajema, IM et al. Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res 2007;8:85 Google Scholar
15 Bolton, SJ, Pinnion, K, Oreffo, V, Foster, M, Pinkerton, KE. Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats. Respir Res 2009;10:118 CrossRefGoogle ScholarPubMed
16 Elwany, S, Ibrahim, AA, Mandour, Z, Talaat, I. Effect of passive smoking on the ultrastructure of the nasal mucosa in children. Laryngoscope 2012;122:965–9Google Scholar
17 Ikeda, K, Shiozawa, A, Ono, N, Kusunoki, T, Hirotsu, M, Homma, H et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil. Laryngoscope 2013;123:E1–9 Google Scholar
18 Matsuwaki, Y, Ookushi, T, Asaka, D, Mori, E, Nakajima, T, Yoshida, T et al. Chronic rhinosinusitis: risk factors for the recurrence of chronic rhinosinusitis based on 5-year follow-up after endoscopic sinus surgery. Int Arch Allergy Immunol 2008;146(suppl 1):77–81 Google Scholar
19 Nakayama, T, Yoshikawa, M, Asaka, D, Okushi, T, Matsuwaki, Y, Otori, N et al. Mucosal eosinophilia and recurrence of nasal polyps – new classification of chronic rhinosinusitis. Rhinology 2011;49:392–6Google Scholar
20 Promsopa, C, Kansara, S, Citardi, MJ, Fakhri, S, Porter, P, Luong, A. Prevalence of confirmed asthma varies in chronic rhinosinusitis subtypes. Int Forum Allergy Rhinol 2016;6:373–7Google Scholar