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The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps

  • Q L Zhao (a1) (a2), L Yu (a2), L L Zhi (a1) (a3), P Jin (a1), X X Zi (a1), L Zhao (a1), A Li (a1), Y Y Tu (a1), L Shi (a1) and H P Zhang (a1)...

Abstract

Objective:

To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features.

Methods:

The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling.

Results:

Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (p < 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity.

Conclusion:

Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.

Copyright

Corresponding author

Address for correspondence: Dr Hong Ping Zhang, Department of Otolaryngology, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, PR China Fax: +86 531 8896 2544 E-mail: tydzhp@sohu.com

References

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1 Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:112
2 Kim, JW, Hong, SL, Kim, YK, Lee, CH, Min, YG, Rhee, CS. Histological and immunological features of non-eosinophilic nasal polyps. Otolaryngol Head Neck Surg 2007;137:925–30
3 Li, CW, Zhang, KK, Li, TY, Lin, ZB, Li, YY, Curotto de Lafaille, MA et al. Expression profiles of regulatory and helper T-cell-associated genes in nasal polyposis. Allergy 2012;67:732–40
4 Baba, S, Kagoya, R, Kondo, K, Suzukawa, M, Ohta, K, Yamasoba, T. T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients. Allergy Asthma Clin Immunol 2015;11:33
5 Gao, T, Ng, CL, Li, C, Li, YY, Duan, C, Shen, L et al. Smoking is an independent association of squamous metaplasia in Chinese nasal polyps. Int Forum Allergy Rhinol 2016;6:6674
6 Brozek, JL, Bousquet, J, Baena-Cagnani, CE, Bonini, S, Canonica, GW, Casale, TB et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466–76
7 Kariya, S, Okano, M, Oto, T, Higaki, T, Makihara, S, Haruna, T et al. Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis. J Laryngol Otol 2014;128:255–62
8 Kariya, S, Okano, M, Higaki, T, Noyama, Y, Haruna, T, Ishihara, H et al. Chronic rhinosinusitis patients have decreased lung function. Int Forum Allergy Rhinol 2014;4:828–33
9 Yang, MS, Lee, HS, Kim, MH, Song, WJ, Kim, TW, Kwon, JW et al. Rhinitis patients with sputum eosinophilia show decreased lung function in the absence of airway hyperresponsiveness. Allergy Asthma Immunol Res 2013;5:232–8
10 Alatas, N, Baba, F, San, I, Kurcer, Z. Nasal polyp diseases in allergic and nonallergic patients and steroid therapy. Otolaryngol Head Neck Surg 2006;135:236–42
11 Soler, ZM, Sauer, DA, Mace, J, Smith, TL. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2009;141:454–61
12 Lee, JJ, Jacobsen, EA, McGarry, MP, Schleimer, RP, Lee, NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy 2010;40:563–75
13 Kariya, S, Okano, M, Higaki, T, Noyama, Y, Haruna, T, Nishizaki, K. Pulmonary function in never-smoker patients with chronic rhinosinusitis. Int Forum Allergy Rhinol 2015;5:990–5
14 Lapperre, TS, Sont, JK, van Schadewijk, A, Gosman, MM, Postma, DS, Bajema, IM et al. Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res 2007;8:85
15 Bolton, SJ, Pinnion, K, Oreffo, V, Foster, M, Pinkerton, KE. Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats. Respir Res 2009;10:118
16 Elwany, S, Ibrahim, AA, Mandour, Z, Talaat, I. Effect of passive smoking on the ultrastructure of the nasal mucosa in children. Laryngoscope 2012;122:965–9
17 Ikeda, K, Shiozawa, A, Ono, N, Kusunoki, T, Hirotsu, M, Homma, H et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil. Laryngoscope 2013;123:E19
18 Matsuwaki, Y, Ookushi, T, Asaka, D, Mori, E, Nakajima, T, Yoshida, T et al. Chronic rhinosinusitis: risk factors for the recurrence of chronic rhinosinusitis based on 5-year follow-up after endoscopic sinus surgery. Int Arch Allergy Immunol 2008;146(suppl 1):7781
19 Nakayama, T, Yoshikawa, M, Asaka, D, Okushi, T, Matsuwaki, Y, Otori, N et al. Mucosal eosinophilia and recurrence of nasal polyps – new classification of chronic rhinosinusitis. Rhinology 2011;49:392–6
20 Promsopa, C, Kansara, S, Citardi, MJ, Fakhri, S, Porter, P, Luong, A. Prevalence of confirmed asthma varies in chronic rhinosinusitis subtypes. Int Forum Allergy Rhinol 2016;6:373–7
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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