Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-05-08T22:47:28.318Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of topical phenypropanolamine on tachyphylaxis and mucociliary clearance in the human nose

Published online by Cambridge University Press:  29 June 2007

K. Holmberg  and
M. Bende
K. Holmberg
Affiliation:
Göteborg and Stövde, Sweden
M. Bende*
Affiliation:
Göteborg and Stövde, Sweden
*
M. Bende, M.D., Phd., Department of Otolaryngology, Central Hospital, S-541 85 Skövde, Sweden.
Get access Rights & Permissions [Opens in a new window]

Abstract

Topical nasal phenylpropanolamine in a 2.5 per cent solution (PPA) was used in an evaluation of the possible development of tachyphylaxis and of possible effects on the mucociliary system after one week of treatment in healthy humans. The tendency of PPA to produce tachyphylaxis was evaluated by rhi-nomanometrie measurements of nasal airway resistance after repeated dose-response provocations. The mucociliary transport time was tested with the saccharine-dye test. No reduced dose-response effect or change in mucociliary transport time was found with PPA, thus indicating that one week of treatment does not contribute to such adverse effects.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 5 , May 1988 , pp. 408 - 410
Copyright
Copyright © JLO (1984) Limited 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andersen, I., Camner, P., Jensen, P. L., Philipsson, K. and Proctor, D. F. (1974) A comparison of nasal and tracheobronchila clearance. Archives of Environmental Health, 29: 290–293.CrossRefGoogle Scholar
Andersson, K. E. and Bende, M. (1984) Adrenoceptors in the control of human nasal mucosal blood flow. Annals of Otology, Rhinology and Laryngology, 93: 179–182.CrossRefGoogle ScholarPubMed
Baldwin, R. L. (1977) Rhinitis medicamentosa (an approach to treatment). Journal of the Medical Association of the State of Alabama, 47: 33–35.Google Scholar
Bende, M., Andersson, K. E., Johansson, C., Sjögren, C., and Svensson, G. (1985) Vascular effects of phenylpropanolamine on human nasal mucosa. Rhinology, 23: 43–48.Google ScholarPubMed
Black, M. J. and Remsen, K. A. (1980) Rhinitis medicamentosa. Canadian Medical Association Journal, 19: 881–884.Google Scholar
Blue, J. A. (1968) Rhinitis medicamentosa. Annals of Allergy, 26: 425–429.CrossRefGoogle ScholarPubMed
Broms, P., Jonson, B. and Lamm, C. J. (1982) Rhinomanometry. A system for numerical description on the nasal airway resistance. Acta Otolaryngologica, 94: 157–168.CrossRefGoogle ScholarPubMed
Eaton, K. K. (1982) The incidence of allergy—has it changed? Clinical Allergy, 12: 107–110.CrossRefGoogle ScholarPubMed
Federal Register (1976) VIII Nasal Decongestants, 41: 38396–38397.Google Scholar
Feinberg, A. R. and Feinberg, S. M. (1971) The “nose drop nose” due to oxymetazoline (Afrin) and other topical vasoconstrictors. Illinois Medical Journal, 140: 50–52.Google Scholar
Fleece, L., Mizes, J. S., Jolly, P. A. and Baldwin, R. L. (1984) Rhinitis medicamentosa; conceptualization, incidence, and treatment. The Alabama Journal of Medical Science, 21: 205–208.Google Scholar
Goodman, L. S. and Gilman, A. (1975); The pharmacological basis of therapeutics. 6th ed. Macmillan Publ. Co, Inc, New York.Google Scholar
Hâkansson, B. and Toremalm, N. G. (1984) Mucociliary function and nasal decongestants. Abstract. 10-Congres de la Société Européenne de Rhinologie, Nancy.Google Scholar
Holmberg, K. and Pipkorn, U. (1985) Mucociliary transport in the human nose—effect of topical glucocorticoid treatment. Rhinology, 23: 181–185.Google ScholarPubMed
Kully, B. M. (1945) The use and abuse of nasal vasoconstrictor medications. Journal of the American Medical Association, 127: 307–310.CrossRefGoogle Scholar
Mabry, R. L. (1982) Rhinitis medicamentosa: The forgotten factor in nasal obstruction. Southern Medical Journal, 75: 817–819.CrossRefGoogle ScholarPubMed
Malm, L., Druce, H. M. and Holgate, S. T. (1985) Vasoconstrictors and antihistamines 140–150. In: Allergic and Vasomotor Rhinitis: Clinical Aspects. Ed.: Mygind, N. and Weeke, B.Munksgaard, Copenhagen.Google Scholar
Mygind, N. (1979) Conventional medical treatment. In: Nasal Allergy, Blackwell Scientific Publications, Oxford.Google Scholar
Mygind, N. (1985) Nasal decongestants. In: Essential Allergy, Blackwell Scientific Publications, Oxford, pp. 337–341.Google Scholar
Mygind, N. and Löwenstein, H. (1982) Allergy and other environmental factors. In: The nose, upper airway physiology and the atmospheric environment. Ed.: Proctor, D. F.Elsevier Bio-medical Press, Amsterdam, New York, Oxford, pp. 377–397.Google Scholar
Petruson, B. (1981) Treatment with xylometazoline (OtrivinR) nosedrops over a six-week period. Rhinology, 19: 167–172.Google Scholar
Petruson, B. (1985) Treatment with nose-drops 89–97. In: Treatment of ear nose and throat infections. National Board of Health and Welfare Drug Information Committee, Sweden.Google Scholar
Petruson, B. and Hansson, H.-A. (1982) Function and structure of the nasal mucosa after 6 weeks use of nose-drops. Acta Otolaryngologica, 94: 563–569.CrossRefGoogle ScholarPubMed
Plym Forshell, G. (1985) Absorption of phenylpropanolamine after intranasal administration. Internal report, LEO 1456F.Google Scholar
Puchelle, E., Aug, F., Pham, Q. T. and Bertrand, A. (1981) Comparison of three methods for measuring nasal mucociliary clearance in man. Acta Otolaryngologica, 91: 297–303.CrossRefGoogle ScholarPubMed
Rijntjes, E. (1985) Nose-drop abuse; a functional and morphological study. Thesis. Gravenhage.Google Scholar
Toohill, R. J., Lehman, R. H., Grossman, T. W. and Belson, T. P. (1981) Rhinitis medicamentosa. Laryngoscope, 91: 1614–1621.CrossRefGoogle ScholarPubMed
Weeke, E. R., Pedersen, P. A., Backman, A. and Siegel, S. G. (1985) Epidemiology 21–30. In: Allergic and Vasomotor Rhinitis: Clinical Aspects. Ed.: Mygind, N. and Weeke, B.Munksgaard, Copenhagen.Google Scholar