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Efficacy of ivermectin against Syphacia obvelata (Nematoda) in mice

Published online by Cambridge University Press:  18 November 2009

D. A. Ostlind ,
M. A. Nartowicz  and
W. G. Mickle
D. A. Ostlind
Affiliation:
Merck Institute for Therapeutic Research, P. O. Box 2000, Rahway, New Jersey 07065, USA
M. A. Nartowicz
Affiliation:
Merck Institute for Therapeutic Research, P. O. Box 2000, Rahway, New Jersey 07065, USA
W. G. Mickle
Affiliation:
Merck Institute for Therapeutic Research, P. O. Box 2000, Rahway, New Jersey 07065, USA
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Abstract

Ivermectin was evaluated against natural and artificial pinworm (Syphacia) infections in mice. Ivermectin given in the diet for 6 days at 0·0005% was 99% effective against both immature and adult worms. A diet level of 0·0004% reduced immature and mature pinworm by 99 and 75%, respectively but 0·0001% was inactive. One oral dose of 2·0mg/kg was 100 and 97% effective against gravid females and immature worms, respectively. A dose of 1·0 mg/kg was 96 and 66% effective against the same parasitic stages. A similar effect was observed against adult male worms where 94 and 86% were removed by one oral dose of ivermectin at 2·0 and 1·0 mg/kg, respectively.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 3 , September 1985 , pp. 257 - 261
Copyright
Copyright © Cambridge University Press 1985

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References

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