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Biologically active casein peptides implicated in immunomodulation

Published online by Cambridge University Press:  01 June 2009

D. Migliore-Samour ,
F. Floc'h  and
P. Jollès
D. Migliore-Samour
Affiliation:
Laboratoire des Protéines, UA CNRS 1188, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France
F. Floc'h
Affiliation:
Rhône-Poulenc Santé, Centre de recherches de Vitry, Vitry sur Seine, France
P. Jollès
Affiliation:
Laboratoire des Protéines, UA CNRS 1188, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France
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Summary

Maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. These data suggest that casein peptides may exert a stimulating function on the immune system of the newborn.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 3: Special Issue: Proceedings of the Hannah Research Institute Casein Conference , May 1989 , pp. 357 - 362
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

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References

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