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Subtle changes in daily functioning predict conversion from normal to mild cognitive impairment or dementia: an analysis of the NACC database

Published online by Cambridge University Press:  08 August 2016

Milap A. Nowrangi ,
Paul B. Rosenberg  and
Jeannie-Marie S. Leoutsakos
Milap A. Nowrangi*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Paul B. Rosenberg*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Jeannie-Marie S. Leoutsakos*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
*
Correspondence should be addressed to: Milap A. Nowrangi, M.D., Paul B. Rosenberg, M.D., and Jeannie-Marie Leoutsakos, Ph.D., Department of Psychiatry, Johns Hopkins Bayview Medical Center, 5300 Alpha Commons Drive, 4th Floor, Baltimore, MD 21224. Office: 410-550-2294; Fax: 410-550-1407. Emails: mnowran1@jhmi.edu., prosenb9@jhmi.edu, jeannie-marie@jhu.edu.
Correspondence should be addressed to: Milap A. Nowrangi, M.D., Paul B. Rosenberg, M.D., and Jeannie-Marie Leoutsakos, Ph.D., Department of Psychiatry, Johns Hopkins Bayview Medical Center, 5300 Alpha Commons Drive, 4th Floor, Baltimore, MD 21224. Office: 410-550-2294; Fax: 410-550-1407. Emails: mnowran1@jhmi.edu., prosenb9@jhmi.edu, jeannie-marie@jhu.edu.
Correspondence should be addressed to: Milap A. Nowrangi, M.D., Paul B. Rosenberg, M.D., and Jeannie-Marie Leoutsakos, Ph.D., Department of Psychiatry, Johns Hopkins Bayview Medical Center, 5300 Alpha Commons Drive, 4th Floor, Baltimore, MD 21224. Office: 410-550-2294; Fax: 410-550-1407. Emails: mnowran1@jhmi.edu., prosenb9@jhmi.edu, jeannie-marie@jhu.edu.
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Abstract

Background:

There are relatively small but observable changes in functional ability in those without Mild cognitive impairment (MCI) or dementia. The present study seeks to understand whether these individuals go on to develop MCI or dementia by assessing the association between baseline Functional Activities Questionnaire (FAQ) and conversion independent and after adjustment for cognitive tests.

Methods:

The NACC database was used to conduct the analysis of which 7,625 participants were initially identified as having more than one visit and who were cognitively normal at their first visit. Cox proportional hazards were used to fit three models that controlled for executive and non-executive cognitive domains. A similar model was used to assess the effect of FAQ subcategories on conversion.

Results:

Of these individuals, 1,328 converted to either MCI or dementia by visit 10. Converters had a total visit 1 FAQ score significantly higher than non-converters indicating more functional impairment at baseline. After adjustment for cognitive tests, the association between visit 1 FAQ and subsequent conversion was not attenuated. Doing taxes, remembering dates, and traveling were individually identified as significant predictors of conversion.

Conclusions:

The FAQ can be used as an indirect measure of functional ability and is associated with conversion to MCI or dementia. There is a selective and significant association between changes in financial ability and conversion that is in accordance with other research of financial capacity.

Keywords

Alzheimer's diseaseMCIactivities of daily livingfunctioning
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 12 , December 2016 , pp. 2009 - 2018
Copyright
Copyright © International Psychogeriatric Association 2016 

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