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Chapter 63 - Ethanol and Other Agents

from Maternal Toxin Exposure

Published online by Cambridge University Press:  07 August 2021

Mirna Lechpammer ,
Marc Del Bigio  and
Rebecca Folkerth
By
Marc Del Bigio
Mirna Lechpammer
Affiliation:
New York University School of Medicine
Marc Del Bigio
Affiliation:
University of Manitoba, Canada
Rebecca Folkerth
Affiliation:
New York University School of Medicine
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Summary

Brain development is a biologically complex process. Many of the metabolic, signaling, and cell adhesion requirements are sensitive to the nutritional and chemical environment. The field of developmental neurotoxicology/neuroteratology is devoted to determining the risk of adverse neurological outcomes in the offspring of pregnant females exposed to exogenous substances (1–7). Hundreds of agents are known or believed to cause human malformations. This chapter will focus on those with an impact on the human nervous system. Those with potential for major structural effects that could cause fetal death or would be obvious in the perinatal period are critical, but we also include a discussion of drugs with (possibly) more subtle effects.

Type
Chapter
Information
Perinatal Neuropathology , pp. 403 - 410
Publisher: Cambridge University Press
Print publication year: 2021

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