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Case 66 - Sinonasal Biphenotypic Sarcoma

Published online by Cambridge University Press:  19 November 2019

Alessandro Franchi
Affiliation:
Università degli Studi di Firenze, Italy
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Summary

A 53-year-old man presented at our hospital after noting a hard nodule in the medial canthus of the left eye. He reported recent episodes of headache. CT imaging demonstrated a 3.5 cm lesion involving the ethmoid with extension in the nasal cavity and frontal sinus. An incisional biopsy was reported as spindle cell neoplasm, most consistent with Schwannoma. The lesion was removed surgically and the patient was alive with no evidence of disease at 14 months follow-up.

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Publisher: Cambridge University Press
Print publication year: 2019

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References

Lewis, JT, Oliveira, AM, Nascimento, AG, Schembri-Wismayer, D, Moore, EA, Olsen, KD, et al. Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol. 2012;36:517525.CrossRefGoogle ScholarPubMed
Wang, X, Bledsoe, KL, Graham, RP, Asmann, YW, Viswanatha, DS, Lewis, JE, et al. Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma. Nat Genet. 2014;46:666668.CrossRefGoogle ScholarPubMed
Huang, SC, Ghossein, RA, Bishop, JA, Zhang, L, Chen, TC, Huang, HY, et al. Novel PAX3-NCOA1 fusions in biphenotypic sinonasal sarcoma with focal rhabdomyoblastic differentiation. Am J Surg Pathol. 2016;40:5159.CrossRefGoogle ScholarPubMed

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