Book contents
- Textbook of Human Reproductive Genetics
- Textbook of Human Reproductive Genetics
- Copyright page
- Contents
- Contributors
- Chapter 1 Basic Genetics and Cytogenetics: A Brief Reminder
- Chapter 2 Application of Whole-Genome Technologies to Assisted Reproductive Treatment
- Chapter 3 Meiosis: How to Get a Good Start in Life
- Chapter 4 Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development
- Chapter 5 DNA Is Not the Whole Story: Transgenerational Epigenesis and Imprinting
- Chapter 6 Genes Are Not the Whole Story: Retrotransposons as New Determinants of Male Fertility
- Chapter 7 Chromosomal Causes of Infertility
- Chapter 8 Genetics of Human Male Infertility: The Quest for Diagnosis and Treatment
- Chapter 9 Genetics of Human Female Infertility
- Chapter 10 Preconception Genetics Analysis/Screening in IVF
- Chapter 11 Genetic Counseling in Assisted Reproductive Treatment
- Chapter 12 Mitochondrial Genetics in Reproductive Medicine
- Chapter 13 Preimplantation Genetic Testing
- Chapter 14 Epigenetics and Assisted Reproductive Technology
- Chapter 15 Human Reproductive Genetics in Medically Assisted Reproduction: Ethical Considerations
- Index
- References
Chapter 12 - Mitochondrial Genetics in Reproductive Medicine
Published online by Cambridge University Press: 15 December 2022
- Textbook of Human Reproductive Genetics
- Textbook of Human Reproductive Genetics
- Copyright page
- Contents
- Contributors
- Chapter 1 Basic Genetics and Cytogenetics: A Brief Reminder
- Chapter 2 Application of Whole-Genome Technologies to Assisted Reproductive Treatment
- Chapter 3 Meiosis: How to Get a Good Start in Life
- Chapter 4 Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development
- Chapter 5 DNA Is Not the Whole Story: Transgenerational Epigenesis and Imprinting
- Chapter 6 Genes Are Not the Whole Story: Retrotransposons as New Determinants of Male Fertility
- Chapter 7 Chromosomal Causes of Infertility
- Chapter 8 Genetics of Human Male Infertility: The Quest for Diagnosis and Treatment
- Chapter 9 Genetics of Human Female Infertility
- Chapter 10 Preconception Genetics Analysis/Screening in IVF
- Chapter 11 Genetic Counseling in Assisted Reproductive Treatment
- Chapter 12 Mitochondrial Genetics in Reproductive Medicine
- Chapter 13 Preimplantation Genetic Testing
- Chapter 14 Epigenetics and Assisted Reproductive Technology
- Chapter 15 Human Reproductive Genetics in Medically Assisted Reproduction: Ethical Considerations
- Index
- References
Summary
Mitochondria are typically described as the powerhouse of the cell, because they are the cytoplasmic organelles responsible for the production of ATP through oxidative phosphorylation. Over the years, it has become clear that their function within the cell is more complex as they are also involved in numerous other processes, including lipid and carbohydrate metabolism, heme biosynthesis, apoptosis, and calcium homeostasis [1]. Human cells contain multiple mitochondria, with the exception of red blood cells that have none. The numbers, mass, morphology, and distribution vary greatly across different cell types, generally depending on the energy demands of the tissues. For instance, sperm contain 20–75 mitochondria in their midpiece, while hepatocytes and muscle cells contain thousands.
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- Textbook of Human Reproductive Genetics , pp. 169 - 184Publisher: Cambridge University PressPrint publication year: 2023