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Chapter 9 - Genetics of Human Female Infertility

Published online by Cambridge University Press:  15 December 2022

By
Svetlana A. Yatsenko  and
Aleksandar Rajkovic
Edited by
Stéphane Viville  and
Karen D. Sermon
Stéphane Viville
Affiliation:
Laboratoire de Génétique Médicale de Strasbourg and Laboratoire de diagnostic génétique, Strasbourg
Karen D. Sermon
Affiliation:
Reproduction and Genetics Research Group, Vrije Universiteit Brussel
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Summary

Infertility is a genetically heterogeneous condition affecting about 10% of women of reproductive age. Genetic studies on animal models have identified thousands of candidate genes that are essential for gonadal development, germline cell differentiation, complex oocyte–granulosa intercellular signaling, gametogenesis, fertilization, and fetal development. A subset of these candidate genes derived from animal models has been found to cause ovarian dysfunction and infertility in humans.

Type
Chapter
Information
Textbook of Human Reproductive Genetics , pp. 132 - 141
Publisher: Cambridge University Press
Print publication year: 2023

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