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The action of 2:4-diamino-6:7-diisopropylpteridine on normal, proguanil- and sulphadiazine-resistant strains of Plasmodium gallinaceum

Published online by Cambridge University Press:  06 April 2009

Elspeth W. McConnachie
Elspeth W. McConnachie
Affiliation:
Molteno Institute, University of Cambridge
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Extract

1. 2:4-diamino-6:7-diisopropylpteridine has an antimalarial index of 1:40, when tested against Plasmodium gallinaceum.

2. 2:4-diamino-1′-methylindolo-(2′:3′-6:7)-pteridine showed no activity against P. gallinaceum in doses tolerated by the chick.

3. Proguanil- and sulphadiazine-proguanil-resistant strains of P. gallinaceum were cross-resistant to 2:4-diamino-6:7-diphenylpteridine.

4. Proguanil- and sulphadiazine-proguanil-resistant strains of P. gallinaceum showed no cross-resistance to 2:4-diamino-6:7-diisopropylpteridine, but were slightly hypersensitive to this compound.

I wish to thank Dr A. Bishop for her interest in this work, and for advice and criticism. The work has been financed by the Medical Research Council.

Type
Research Article
Information
Parasitology , Volume 42 , Issue 3-4 , January 1953 , pp. 272 - 276
Copyright
Copyright © Cambridge University Press 1953

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