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Molecular Genetics of Mental Disorders with Particular Reference to Affective Disorders

Published online by Cambridge University Press:  16 April 2020

D Souery ,
O Lipp ,
B Mahieu  and
J Mendlewicz
D Souery
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, 808 Route de Lennik, 1070Brussels, Belgium
O Lipp
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, 808 Route de Lennik, 1070Brussels, Belgium
B Mahieu
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, 808 Route de Lennik, 1070Brussels, Belgium
J Mendlewicz*
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, 808 Route de Lennik, 1070Brussels, Belgium
*
*Correspondence and reprints.
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Summary

The present article reviews the recent molecular genetic findings in affective disorders. Results of linkage and association studies are discussed in regard to the main limitations of these approaches in psychiatric disorders. On the whole, linkage and association studies contributed to the localisation of some potential vulnerability genes for Bipolar affective disorder on chromosomes 18, 5, 11, 4, 21 and X. The hypothesis of anticipation in affective disorders is also considered in light of interesting results with trinucleotide repeat mutations.

Keywords

affective disordersmolecular geneticsanticipation
Type
Symposia
Information
European Psychiatry , Volume 12 , Issue S2 , 1997 , pp. 63s - 69s

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References

Baron, MFreimer, NFRisch, NDiminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genetics 1993;3:49–55CrossRefGoogle ScholarPubMed
Benjamin, JPress, JMoaz, Bet al.Linkage of normal personality trait to the color-blindness gene: preliminary evidence. Biol Psychiatry 1993;34: 581–583CrossRefGoogle ScholarPubMed
Benjamin, JLi, LPaterson, CGreenberg, BMurphy, DLHamer, DHPopulation and familial association between the D4 dopamine receptor gene and measures of Novelty-Seeking. Nature Genetics 1996; 12: 81–84CrossRefGoogle ScholarPubMed
Berrettini, WHColdin, LRGelernter, Jet al.X chromosome markers and manic-depressive illness: rejection of linkage to Xq28 in nine bipolar pedigrees. Arch Gen Psychiatry 1990; 47: 366–373CrossRefGoogle ScholarPubMed
Berrettini, WHFerraro, TNGoldin, LRet al.Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994; 91: 5918–5922CrossRefGoogle ScholarPubMed
Blackwood, DHe, LMorris, Set al.A locus for bipolar affective disorder on chromosome 4p. Nature Genetics 1996; 12: 427–430CrossRefGoogle ScholarPubMed
Bredbacka, PEBekkarinen, PPeltonen, Let al.Bipolar disorder in an extended pedigree with a segregation pattern compatible with X-linked transmission: exclusion of the previously reported linkage to F9. Psychialr Genet 1993; 3: 79–87CrossRefGoogle Scholar
Byerley, WHoff, MHolik, Jet al.A linkage study with D5 Dopamine and α25-ashinergic receptor genes in six multiple bipolar pedigrees. Psychiatry Genet 1994; 4: 121–124CrossRefGoogle ScholarPubMed
Cloninger, CRA systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 1987; 44: 573–588CrossRefGoogle ScholarPubMed
Coon, HJensen, SHoff, Met al.A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance. Am J Hum Genet 1993;52:1234–1249Google ScholarPubMed
Costa, PTJMcCrae, RRRevised NEO Personality Inventory (NEOPI-R) and NEO Five Inventory (NEO-FFI) Professional Manual. Odessa, FL: Psychological Assessment Ressources, 1992Google Scholar
De Bruyn, ARaeymaekers, PMendelbaum, Ket al.Linkage analysis of bipolar illness with X-chromosome DNA markers: a susceptibility gene in Xq27–28 cannot be excluded. Am J Med Genet 1994;54:411–419CrossRefGoogle Scholar
De Bruyn, ASouery, DMendelbaum, Ket al.Linkage analysis of 2 families with bipolar illness and chromosome 18 markers. Biol Psychiatry 1996; 39: 679–688CrossRefGoogle Scholar
Detera-Wadleigh, SDBerrettini, WHGoldin, LRet al.A systematic search for a bipolar predisposing locus on chromosome 5. Neuropsychopharmacology 1992; 6: 219–229Google ScholarPubMed
Ebstein, RPNovick, OUmansky, RPriel, BOsher, YBlaine, DBennett, ERNemaov, LKatz, MBelmaker, RHDopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty-Seeking. Nature Genetics 1996; 12: 78–80CrossRefGoogle ScholarPubMed
Engström, CJohansson, ELLangström, MThornlund, ASChotai, JAdolfsson, RNylander, POAnticipation in unipolar affective disorder. J Affect Dis 1995; 35: 31–40CrossRefGoogle ScholarPubMed
Fischbeck, KHPaulson, HLTrinucleotide repeats in neurogenetic disorders. Ann Rev Neurosci 1996; 19:Google Scholar
Freimer, NReus, VEscamilla, MGenetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BP1) at 18q22–q23. Nature Genetics 1996; 12: 436–441CrossRefGoogle Scholar
Gejman, PVDetera-Wadleigh, SMartinez, MMet al.Manic depressive illness not linked to factor IX in a independent series of pedigrees. Genomics 1990; 8: 648–655CrossRefGoogle ScholarPubMed
Gershon, ESBadner, JADetera-Waldeigh, SDet al.Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees. Am J Med Genet (Neuropsychiatr Genet) 1996; 67: 202–2073.0.CO;2-N>CrossRefGoogle ScholarPubMed
Gill, MCastle, DHunt, Net al.Tyrosine hydroxylase polymorphisms and bipolar affective disorder. J Psychiatr Res 1991; 25: 179–184CrossRefGoogle ScholarPubMed
Hamer, DHHu, SMagnusson, VLet al.A linkage between DNA markers on the X chromosome and male sexual orientation. Science 1993; 261: 321–327CrossRefGoogle ScholarPubMed
Hodge, SELinkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations. Am J Med Genet 1993; 53: 367–384Google ScholarPubMed
Hodge, SEWhat association analysis can and cannot tell us about the genetics of complex disease. Am J Med Genet 1994; 54: 318–323CrossRefGoogle ScholarPubMed
Hu, SPattatucci, AMPatterson, Cet al.Linkage between sexual orientation and chromosome Xq28 in males but not females. Nature Genetics 1995; 11: 248–256CrossRefGoogle Scholar
Inayama, YYoneda, HSakai, Tet al.Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker. Am J Med Genet 1993; 48: 87–89CrossRefGoogle ScholarPubMed
Kelsoe, JRSadovnick, ADKristbjarnarson, Het al.Possible locus of biolar disorder near thedopamine transporter on chromosome 5. Am J Med Genet 67 (6) 1996 533–5403.0.CO;2-I>CrossRefGoogle Scholar
Körner, JFritz, JPropping, PRFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders. Psychiatr Res 1990; 32: 275–280CrossRefGoogle ScholarPubMed
Körner, JRietschel, MHunt, Net al.Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls. Psychiatr Genet 1994; 4: 167–175CrossRefGoogle Scholar
Leboyer, MMalafosse, ABoularand, Set al.Tyrosine hydroxylase polymorphism associated with manic depressive illness. Lancet 1990; 335: 1219CrossRefGoogle ScholarPubMed
Lesch, KPBengel, DHeils, Aet al.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527–1531CrossRefGoogle ScholarPubMed
Lim, LCCPowell, JFMurray, RMonoamine oxidase A gene and bipolar affective disorder. Am J Hum Genet 1994; 54: 1122–1124Google ScholarPubMed
Lindblad, KNylander, PODe Bruyn, Aet al.Expansion of trinucleotide CAG repeats detected in Bipolar Affective Disorder by the RED-(rapid expansion detection) method. Neurobiol Dis 1995; 2: 55–62CrossRefGoogle Scholar
Lipp, OSouery, DMahieu, Bet al.Anticipation in affective disorders [abstract]. Psychiatr Genet 1995; 5 (suppl 1) S8CrossRefGoogle Scholar
Lucotte, GLandoulsi, ABerriche, Set al.Manic depressive illness is linked to factor IX in a French pedigree. Ann Genet 1992; 35: 93–95Google Scholar
Mclnnis, MGMcMahon, FJChase, GAet al.Anticipation in bipolar affective disorder. Am J Hum Genet 1993; 53: 385–390Google Scholar
Meloni, RLeboyer, MBellivier, FBarbe, BSamolyk, DMallet, JAssociation of manic depressive illness with the tyrosine hydroxylase microsatellite marker. Lancet 1995; 345: 932CrossRefGoogle ScholarPubMed
Mendlewicz, JSimon, PSevy, Set al.Polymorphic DNA marker on chromosome and manic-depression. Lancet 1987; 1: 1230–1232CrossRefGoogle ScholarPubMed
Nöthen, MMKomer, JLanczik, Met al.Tyrosine hydroxylase polymorphism and manic depressive illness. Lancet 1990; 336: 575CrossRefGoogle ScholarPubMed
Nöthen, MMCichon, SErdmann, Jet al.Pseudoautosomal marker DXYS20 and manic depression. Am J Hum Genet 1993; 52: 841–842Google ScholarPubMed
Nylander, POEngstrom, CChotai, JWahlstrom, JAdolfsson, RAnticipation in Swedish families with bipolar affective disorder. J Med Gen 1994; 31: 686–689CrossRefGoogle ScholarPubMed
O’Donovan, MCGuy, CCraddock, NMurphy, KCCardno, AGJones, LAOwen, MJMcGuffin, PExpanded CAG repeats in schizophrenia and bipolar disorder. Nature Genetics 1995;10:380–381CrossRefGoogle ScholarPubMed
Ott, J(1991) Analysis of Human Genetic Linkage 2nd edn. Baltimore: Johns Hopkins University PressGoogle Scholar
Parsian, ATodd, RDBipolar disorder and the pseudoautosomal region: an association study. Am J Med Genet 1994; 54: 5–7CrossRefGoogle Scholar
Pauls, DLOtt, JPaul, SMet al.Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. Am J Hum Genet 1995; 57: 636–643Google ScholarPubMed
Pekkarinen, PTerwilliger, JBredbacka, PELonnqvist, JPeltonen, LEvidence of a predisposing locus to bipolar disorder on Xq24–q27.1 in an extended Finnish pedigree. Genome Res 1995; 5: 105–115CrossRefGoogle Scholar
Penrose, LSThe problem of anticipation in pedigrees of dystrophia myotonica. Ann Eugenics 1948; 14: 125–132CrossRefGoogle ScholarPubMed
Propping, PNothen, MMFimmers, Ret al.Linkage versus association studies in complex diseases. Pychiatr Genet 1993; 3: 136Google Scholar
Souery, DLipp, OMahieu, Bet al.Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1 and TH genes. Am J Med Genet (Neuropsychiatr Genet) 1996a;67 (6):551–5553.0.CO;2-K>CrossRefGoogle ScholarPubMed
Souery, DPapadimitriou, GNMendlewicz, JNew genetic approaches in affective disorders. In Papadimitriou, GNMendlewicz, JGenetics of Mental Disorders. II. Clinical Issues. Baillière's Clinical Psychiatry, International Practice and Research. London: Bailliere Tindall, February 1996b:2(1):1–13Google Scholar
Souery, DMendelbaum, KDe bruyn, Aet al.Tyrosine hydroxylase polymorphisms in unipolar and bipolar affective disorders: a preliminary report. Biol Psychiatry 1996c;39(8):679–688Google Scholar
Stine, CXu, JKoskela, Ret al.Evidence for linkage of bipolar disorder to chromosome 18 with parent-of-origin effect. Am J Hum Genet 1996; 57: 1384–1394Google Scholar
Straub, RELehner, TLuo, Yet al.A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genetics 1994; 8: 291–296CrossRefGoogle ScholarPubMed
Terwilliger, JDOtt, JA haplotype-based haplotype relative risk statistic. Hum Hered 1992; 42: 337–346CrossRefGoogle Scholar
Todd, RO’Malley, KPopulation frequencies of tyrosine hydroxylase RFLP in bipolar affective disorders. Biol Psychiatry 1989; 25: 626–630CrossRefGoogle Scholar
Trottier, YLutz, YStevanin, Get al.Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias. Nature 1995; 378: 403–405CrossRefGoogle ScholarPubMed
Yoneda, HSakai, TIshida, Tet al.An association between manic-depressive illness and a pseudoautosomal DNA marker. Ant J Hum Genet 1992;51:1172–1173Google Scholar
Weiss, KMGenetic Variation and Human Disease: Principles and Evolutionary Approaches. Cambridge: Cambridge University Press, 1993CrossRefGoogle Scholar
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