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Antibodies in Serum of Patients with Alzheimer's Disease Cause Immunolysis of Cholinergic Nerve Terminals from the Rat Cerebral Cortex

Published online by Cambridge University Press:  18 September 2015

H.F. Bradford ,
P. Foley ,
M. Docherty ,
H. Fillit ,
V.N. Luine ,
B. McEwen ,
G. Bucht ,
B. Winbald  and
J. Hardy
H.F. Bradford*
Affiliation:
Department of Biochemistry, Imperial College of Science and Technology, London, Rockefeller University, New York
P. Foley
Affiliation:
Department of Biochemistry, Imperial College of Science and Technology, London, Rockefeller University, New York
M. Docherty
Affiliation:
Department of Biochemistry, Imperial College of Science and Technology, London, Rockefeller University, New York
H. Fillit
Affiliation:
Department of Biochemistry, St. Mary's Hospital Medical School, London, Rockefeller University, New York
V.N. Luine
Affiliation:
Department of Biochemistry, St. Mary's Hospital Medical School, London, Rockefeller University, New York
B. McEwen
Affiliation:
Department of Biochemistry, St. Mary's Hospital Medical School, London, Rockefeller University, New York
G. Bucht
Affiliation:
Department of Geriatric Medicine, University of Umea, Sweden
B. Winbald
Affiliation:
Department of Geriatric Medicine, Karolinska Institute, Sweden
J. Hardy
Affiliation:
Department of Biochemistry, St. Mary's Hospital Medical School, London, Rockefeller University, New York
*
Department of Biochemistry, Imperial College of Science and Technology, London SW7 2AZ UK
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Abstract:

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A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue S4 , November 1989 , pp. 528 - 534
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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