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Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women

Published online by Cambridge University Press:  26 October 2011

Silvia Valtueña ,
Kevin Cashman ,
Simon P. Robins ,
Aedin Cassidy ,
Alwine Kardinaal  and
Francesco Branca
Silvia Valtueña
Affiliation:
Unit of Human Nutrition, National Institute for Research on Food and Nutrition, Via Ardeatina 546, 1-00179 Rome, Italy
Kevin Cashman
Affiliation:
Nutritional Sciences, Department of Food Science, Food Technology and Nutrition, University College, Cork, Republic of Ireland
Simon P. Robins
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
Aedin Cassidy
Affiliation:
Unilever Research, Molecular Nutrition and Physiology Unit, Colworth House, Sharnbrook, Bedford MK44 1LQ, UK
Alwine Kardinaal
Affiliation:
Department of Nutritional Physiology, TNO Nutrition and Food Research Institute, PO Box 360, 3700 AJ Zeist, The Netherlands
Francesco Branca*
Affiliation:
Unit of Human Nutrition, National Institute for Research on Food and Nutrition, Via Ardeatina 546, 1-00179 Rome, Italy
*
*Corresponding author: Dr F. Branca, fax +39 06 50 31 592, email f.branca@agora.it
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Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These questions can only be addressed by conducting well-planned, randomised clinical trials that take into consideration present knowledge in the oestrogen, phyto-oestrogen and bone fields. This review is intended to provide hints for critical decision-making about the selection of subjects, type of intervention, suitable outcome measures and variables that need to be controlled.

Keywords

IsoflavonesMenopauseClinical trials
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue S1: Effects of Phyto-oestrogens on Bone Health: the VENUS Concerted Action , June 2003 , pp. S87 - S99
Copyright
Copyright © The Nutrition Society 2003

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