Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-17T19:36:35.656Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of peroxidation products in thermoxidised dietary oil in female rats during rearing, pregnancy and lactation on their reproductive performance and the antioxidative status of their offspring

Published online by Cambridge University Press:  09 March 2007

Corinna Brandsch  and
Klaus Eder
Corinna Brandsch
Affiliation:
Institute of Nutritional Sciences, Martin-Luther-University Halle-Wittenber, Emil-Abderhalden-Straße 26, D-06108 Halle/Saale, Germany
Klaus Eder*
Affiliation:
Institute of Nutritional Sciences, Martin-Luther-University Halle-Wittenber, Emil-Abderhalden-Straße 26, D-06108 Halle/Saale, Germany
*
*Corresponding author: fax +49 345 552 7124, email eder@landw.uni-halle.de
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The present study was performed to investigate whether lipid peroxidation products in thermoxidised dietary oil fed during rearing, pregnancy and lactation influences the reproductive performance of female rats and the antioxidant status of their offspring. Twenty-four female rats were divided into two groups at 4 weeks of age. They were fed diets containing fresh or oxidised oil (the latter prepared by heating at a temperature of 50°C for 16 d) for 14 weeks. At the age of 12 weeks female rats were mated. The number of total pups and pups born alive was not different between both groups. However, individual pups and litters of dams fed oxidised oil were lighter at birth and gained less weight during the suckling period than those of dams fed fresh oil (P>0·05). Pups of dams fed oxidised oil contained less protein and more fat in their carcasses than those of dams fed fresh oil (P>0·05). The milk of dams fed oxidised oil had a lower concentration of triacylglycerols and a lower energy content than that of dams fed the fresh oil (P>0·05). The pups of dams fed oxidised oil had higher concentrations of lipid peroxidation products in the liver at birth and day 19 of lactation than those of dams fed fresh oil (P>0·05). In conclusion, the present study shows that feeding oxidised oil with a high concentration of lipid peroxidation products to female rats during rearing, pregnancy and lactation influences the development and antioxidant status of fetus and suckling pups.

Keywords

Thermoxidised fatLactationLipid peroxidationRat
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 2 , August 2004 , pp. 267 - 275
Copyright
Copyright © The Nutrition Society 2004

References

Adachi, J, Kudo, R, Ueno, Y, Hunter, R, Rajendram, R, Want, E & Preedy, VRHeart 7-hydroperoxycholesterol and oxysterols are elevated in chronically ethanol-fed rats. J Nutr (2001) 131, 2916–2920.CrossRefGoogle ScholarPubMed
AOAC International Basic Calculations for Chemical and Biological Analysis, 2nd ed. [Efiok, BJS and Eduok, EE, editors]. Gaithersberg, MD: AOAC International. (2001)Google Scholar
Arikan, S, Konukoglu, D, Arikan, C, Akcay, T & Davas, ILipid peroxidation and antioxidant status in maternal and cord blood. Gynecol Obstet Invest (2001) 51, 145–149.CrossRefGoogle ScholarPubMed
Atwater, WO & Bryant, APThe availability and food values of food materials. In 12th Annual Report of the Storrs, CT, Agricultural Experimental Station, pp. 73 – 110. Storrs, CT: University of Connecticut. (1900)Google Scholar
Baldi, A, Savioni, G, Pinotti, L, Monfardini, E, Cheli, F & Dell’Orto, VEffects of vitamin E and different energy sources on vitamin E status, milk quality and reproduction in transition cows. J Vet Med A Physiol Pathol Clin Med (2000) 47, 599 – 608.CrossRefGoogle ScholarPubMed
Balz, M, Schulte, E & Thier, H-PSimultaneous determination of a-tocopherol acetate, tocopherols and tocotrienols by HPLC with fluorescence detection in foods. Fat Sci Technol (1993) 95, 215 – 220.Google Scholar
Björkhem, IDo oxysterols control cholesterol homeostasis? J Clin Invest (2002) 110, 725–730.CrossRefGoogle ScholarPubMed
Blanc, P, Revol, A & Pacheco, HChronical ingestion of oxidized oil in the rat: effect on lipid composition and on cytidylyl transferase activity in various tissues. Nutr Res (1992) 12, 833 – 844.CrossRefGoogle Scholar
Borsting, CF, Engberg, RM, Jakobsen, K, Jensen, SK & Andersen, JOInclusion of oxidized fish oil in mink diets. 1. The influence on nutrient digestibility and fatty acid accumulation in tissues. J Anim Physiol Anim Nutr (1994) 72, 132 – 145.CrossRefGoogle Scholar
Bradford, MMA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 72, 248 – 254.CrossRefGoogle ScholarPubMed
Brandsch, C, Ringseis, R & Eder, KHigh dietary iron concentrations enhance the formation of cholesterol oxidation products in the liver of adult rats fed salmon oil with minimal effects on antioxidant status. J Nutr (2002) 132, 2263 – 2269.CrossRefGoogle ScholarPubMed
Breuer, O & Björkhem, IUse of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. J Biol Chem (1995) 270, 20278 – 20284.CrossRefGoogle ScholarPubMed
Cederberg, J, Siman, CM & Eriksson, UJCombined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr Res (2001) 49, 755 – 762.CrossRefGoogle ScholarPubMed
Chao, PM, Chao, CY, Lin, FJ & Huang, COxidized frying oil up-regulates hepatic acyl-CoA oxidase and cytochrome P450 4 A1 genes in rats and activates PPARalpha. J Nutr (2001) 131, 3166 – 3174.CrossRefGoogle ScholarPubMed
Cho, SH & Choi, YSLipid peroxidation and antioxidant status is affected by different vitamin E levels when feeding fish oil. Lipids (1994) 29, 47 – 52.CrossRefGoogle ScholarPubMed
De Hoff, JL, Davidson, JH & Kritchevsky, VAn enzymatic assay for determining free and total cholesterol in tissues. Clin Chem (1978) 24, 433 – 435.CrossRefGoogle Scholar
Deutsche Gesellschaft für Fettwissenschaft Einheitsmethoden zur Untersuchung von Fetten, Fettprodukten, Tensiden und verwandten Stoffen. (Standard Methods for Analysis of Fats, Fat Products, Tensides and Related Substances). Stuttgart: Wissenschaftliche Verlagsgesellschaft. (1994)Google Scholar
Eder, K & Kirchgessner, MThe effect of dietary vitamin E supply and a moderately oxidized oil on activities of hepatic lipogenic enzymes in rats. Lipids (1998) 33, 277 – 283.CrossRefGoogle Scholar
Eder, K, Suelzle, A, Skufca, P, Brandsch, C & Hirche, FEffects of dietary thermoxidized fats on expression and activities of lipogenic enzymes in rats. Lipids (2003) 38, 31 – 38.CrossRefGoogle ScholarPubMed
Endo, Y, Li, CM, Tagiri-Endo, M & Fujimoto, KA modified method for the estimation of total carbonyl compounds in heated and frying oils using 2-propanol as a solvent. J Am Oil Chem Soc (2001) 78, 1021 – 1024.CrossRefGoogle Scholar
Engberg, RM, Lauridsen, C, Jensen, SK & Jakobsen, KInclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. Poult Sci (1996) 75, 1003 – 1011.CrossRefGoogle ScholarPubMed
Focant, M, Mignolet, E, Marique, M, Clabots, F, Breyne, T, Dalemans, D & Larondelle, YThe effect of vitamin E supplementation of cow diets containing rapeseed and linseed on the prevention of milk fat oxidation. J Dairy Sci (1998) 81, 1095 – 1101.CrossRefGoogle ScholarPubMed
Halliwell, B & Gutteridge, JMFree Radicals in Biology and Medicine. Oxford: Clarendon Press. (1989)Google Scholar
Hara, A & Radin, SNLipid extraction of tissues with a lowtoxicity solvent. Anal Biochem (1978) 90, 420 – 426.CrossRefGoogle ScholarPubMed
Henderson, GI, Chen, JJ & Schenker, SEthanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci (1999) 15, 541 – 550.Google Scholar
Hermes-Lima, M, Willmore, WG & Storey, KBQuantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation. Free Radic Biol Med (1995) 19, 271 – 280.CrossRefGoogle Scholar
Herrera, ELipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine (2002) 19, 43 – 55.CrossRefGoogle ScholarPubMed
International Union of Pure and Applied Chemistry Determination of polar compounds, polymerized and oxidized triacylglycerols, and diacylglycerols in oils and fats. Pure Appl Chem (2000) 72, 1563 – 1575.CrossRefGoogle Scholar
Lauridsen, C, Engel, H, Jensen, SK, Craig, AM & Traber, MGLactating sows and suckling piglets preferentially incorporate RRR- over all-rac-alpha-tocopherol into milk, plasma and tissues. J Nutr (2002) 132, 1258 – 1264.CrossRefGoogle ScholarPubMed
Liu, JF & Huang, CJTissue a-tocopherol retention in male rats is compromised by feeding diets containing oxidized frying oil. J Nutr (1995) 125, 3071 – 3080.Google Scholar
Mahan, DC, Kim, YY & Stuart, RLEffect of vitamin E sources (RRR- or all-rac-alpha-tocopheryl acetate) and levels on sow reproductive performance, serum, tissue, and milk alpha-tocopherol contents over a five-parity period, and the effects on the progeny. J Anim Sci (2000) 78, 110 – 119.CrossRefGoogle Scholar
Martin, JC, Joffre, F, Siess, MH, Vernevaut, MF, Collenot, P, Genty, M & Sebedio, JLCyclic fatty acid monomers from heated oil modify the activities of lipid synthesizing and oxidizing enzymes in rat liver. J Nutr (2000) 130, 1524 – 1530.CrossRefGoogle ScholarPubMed
Mori, TA, Croft, KD, Puddey, IB & Beilin, LJAnalysis of native and oxidized low-density lipoprotein oxysterols using gas chromatography-mass spectrometry with selective ion monitoring. Redox Rep (1996) 2, 25 – 34.CrossRefGoogle ScholarPubMed
National Research Council Nutrient Requirements of Laboratory Animals. Washington, DC: National Academy Press. (1995)Google Scholar
Recknagel, RO & Glende, EA Jr Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol (1984) 105, 331 – 337.CrossRefGoogle ScholarPubMed
Ringseis, R & Eder, KInsufficient dietary vitamin E increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil. J Nutr (2002) 132, 3732 – 3735.CrossRefGoogle ScholarPubMed
Rogers, MS, Mongelli, M, Tsang, KH & Wang, CCFetal and maternal levels of lipid peroxides in term pregnancies. Acta Obstet Gynecol Scand (1999) 78, 120 – 124.CrossRefGoogle ScholarPubMed
Sidwell, CG, Salwin, H, Benca, M & Mitchell, JH Jr The use of thiobarbituric acid as a measure of fat oxidation. J Am Oil Chem Soc (1954) 31, 603 – 606.CrossRefGoogle Scholar
Viana, M, Aruoma, OI, Herrera, E & Bonet, BOxidative damage in pregnant diabetic rats and their embryos. Free Radic Biol Med (2000) 29, 1115 – 1121.CrossRefGoogle ScholarPubMed
Viana, M, Barbas, C, Castro, M, Herrera, E & Bonet, BAlpha-tocopherol concentration in fetal and maternal tissues of pregnant rats supplemented with alpha-tocopherol. Ann Nutr Metab (1999) 43, 107 – 112.CrossRefGoogle ScholarPubMed
Vine, DF, Mamo, CL, Beilin, LJ, Mori, TA & Croft, KDDietary oxysterols are incorporated in plasma triglyceriderich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. J Lipid Res (1998) 39, 1995 – 2004.CrossRefGoogle ScholarPubMed