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Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects

Published online by Cambridge University Press:  09 March 2007

Christine M. Williams ,
F. Moore ,
L. Morgan  and
J. Wright
Christine M. Williams
Affiliation:
The Nutrition Research Group, Department of Biochemistry, University of Surrey, Guildford GU2 5XH
F. Moore
Affiliation:
The Nutrition Research Group, Department of Biochemistry, University of Surrey, Guildford GU2 5XH
L. Morgan
Affiliation:
The Nutrition Research Group, Department of Biochemistry, University of Surrey, Guildford GU2 5XH
J. Wright
Affiliation:
The Nutrition Research Group, Department of Biochemistry, University of Surrey, Guildford GU2 5XH
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Abstract

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The present study reports results from two investigations to determine effects of a 6-week period of moderate n-3 fatty acid supplementation (2.7 g/d) on fasting and on postprandial triacylglycerol and metabolic hormone concentrations in response to standard test meals. In the first study postprandial responses were followed for 210 min after an early morning test meal challenge; in the second study responses to an evening test meal were followed during the evening and overnight for a total period of 12 h. In both studies postprandial triacylglycerol responses to the test meals were significantly reduced after compared with before fish-oil supplementation. In the second study the triacylglycerol peak response seen between 200 and 400 min in subjects studied before supplementation with fish oils was almost completely absent in the same subjects after 6 weeks of n-3 fatty acid supplementation. Analysis of fasting concentrations of metabolites and hormones was carried out on the combined data from the two studies. There were no significant differences in total, low-density-lipoprotein- or high-density-lipoprotein-cholesterol concentrations during fish-oil supplementation, although there was considerable individual variation in cholesterol responses to the supplement. Concentrations of Apo-B and Apo-A1 were unchanged during supplementation with fish oils. Fasting and early morning postprandial GIP concentrations were lower in subjects taking fish oils, possibly due to acute effects of fish-oil capsules taken on the evening before the studies. In both studies fasting insulin and glucose and postprandial insulin concentrations remained unchanged following fish-oil supplementation. The results do not support the view that triacylglycerol-lowering effects of n-3 fatty acids are due to modulation of insulin secretion mediated via the enteroinsular axis. Further studies are required to determine the precise mechanism by which fish oils reduce both fasting and postprandial triacylglycerol concentrations.

Keywords

Polyunsaturated fatty acidsPostprandial triacylglycerolsMetabolic hormones
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 3 , November 1992 , pp. 655 - 666
Copyright
Copyright © The Nutrition Society 1992

References

Atkinson, P. M., Wheeler, M. C., Mendelson, D., Piennar, N. & Chetty, N. (1987). Effects of a 4-week, freshwater fish (trout) diet on platelet aggregation, platelet fatty acids, serum lipids and coagulation factors. American Journal of Hematology 24, 143–149.CrossRefGoogle ScholarPubMed
Bergseth, S., Christiansen, E. N. & Bremer, J. (1986). The effect of feeding fish oils, vegetable oils and clofibrate on the ketogenesis from long chain fatty acids in hepatocytes. Lipids 21, 508–514.CrossRefGoogle ScholarPubMed
Brunzell, J., Hazzard, W. R., Porte, D. & Bierman, E. L. (1973). Evidence for a common, saturable triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. Journal of Clinical Investigation 52, 1578–1585.CrossRefGoogle ScholarPubMed
Carlson, L. A., Bottiger, L. E. & Ahfeldt, P.-E. (1979). Risk factors for myocardial infarction in the Stockholm Prospective Study. Acta Medica Scandinavica 206, 351–360.CrossRefGoogle ScholarPubMed
Castelli, W. P. (1986). The triglyceride issue: a view from Framingham. American Heart Journal 112, 432–437.CrossRefGoogle ScholarPubMed
Cohn, J. S., McNamara, J. R., Cohn, S. D., Ordovas, J. M. & Schaefer, E. J. (1988). Postprandial plasma lipoprotein changes in subjects of different ages. Journal of Lipid Research 29, 469–479.CrossRefGoogle ScholarPubMed
Friedwald, W. T., Levy, R. I. & Frederickson, D. S. (1972). Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.CrossRefGoogle Scholar
Gibbons, G. F. (1990). Assembly and secretion of very-low-density lipoprotein. Biochemical Journal 268, 1–13.CrossRefGoogle ScholarPubMed
Harris, W. S. (1989). Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. Journal of Lipid Research 30, 785–807.CrossRefGoogle ScholarPubMed
Harris, W. S., Connor, W. E., Alam, N. & Illingworth, D. R. (1988). Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, 1451–1460.CrossRefGoogle ScholarPubMed
Harris, W. S., Connor, W. E. & McMurry, M. P. (1983). The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 32, 179–184.CrossRefGoogle ScholarPubMed
Herzberg, G. R. & Rogerson, M. (1988). LPL activity in muscle and adipose tissue of rats fed glucose or fructose based diets containing fish oil. FASEB Journal 2, 852A.Google Scholar
Kane, J. P., Chen, G. C., Hamilton, R. L., Hardman, D. A., Malloy, M. J. & Havel, R. J. (1983). Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia. Arteriosclerosis 3, 47–56.CrossRefGoogle ScholarPubMed
Lardinois, C. K., Starich, G. H. & Mazzaferri, E. (1988). The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition 7, 241–247.CrossRefGoogle ScholarPubMed
Morgan, L. M., Hampton, S. M., Tredger, J. A., Cramb, R. & Marks, V. (1988). Modifications of gastric inhibitory polypeptide (GIP) secretion in man by a high-fat diet. British Journal of Nutrition 59, 373–380.CrossRefGoogle Scholar
Nestel, P. J., Connor, W. E., Reardon, M. R., Connor, S., Wong, S. & Boston, R. (1984). Suppression by diets rich in fish oil of very low density lipoprotein production in man. Journal of Clinical Investigation 74, 72–89.CrossRefGoogle Scholar
Reardon, M. F., Nestel, P. J., Craig, I. H. & Harper, R. W. (1985). Lipoprotein predictors of the severity of coronary artery disease in men and women. Circulation 71, 881–888.CrossRefGoogle ScholarPubMed
Rustan, A. C., Nossen, J. O., Christiansen, E. N. & Drevon, C. A. (1988). EPA reduces hepatic production and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A: 1,2-diacylglycerolacyltransferase. Journal of Lipid Research 29, 1417–1426.CrossRefGoogle Scholar
Sanders, T. A. B., Vickers, M. & Haines, A. P. (1981). Effect on blood lipids and haemostasis of a supplement of cod liver oil, rich in EPA and DHA, in healthy young men. Clinical Science 61, 317–324.CrossRefGoogle Scholar
Simons, L. A., Dwyer, T., Simons, J., Bermann, J., Branson, J. & Morgan, J. (1987). Chylomicrons and chylomicron remnants in coronary artery disease: a control study. Atherosclerosis 65, 181–189.CrossRefGoogle ScholarPubMed
Singer, P., Jaeger, W., Wirth, M., Voigt, S., Naumann, E., Zimontkowski, S., Hadju, S. & Godicke, W. (1983). Lipid and blood pressure-lowering effect of mackerel diet in man. Atherosclerosis 49, 99–108.CrossRefGoogle ScholarPubMed
Singer, P., Wirth, H., Voigt, S., Richter-Heinrich, E., Godicke, E., Berger, I., Naumann, E., Listing, J., Hartrodt, W. & Taube, C. (1985). Blood pressure- and lipid-lowering effect of mackerel and herring diets in patients with mild essential hypertension. Atherosclerosis 56, 223–235.CrossRefGoogle ScholarPubMed
Stender, S. & Zilversmit, D. B. (1981). Comparison of cholesterol ester transfer from chylomicrons and other plasma lipoproteins to aorta intima-media of cholesterol-fed rabbit. Arteriosclerosis 2, 493–499.CrossRefGoogle Scholar
von Lossonczy, T. O., Ruiter, D. A., Bronsgeest-Schoute, H. C., van Gent, C. M. & Hermuss, R. J. J. (1978). The effect of a fish diet on serum lipids in healthy human subjects. American Journal of Clinical Nutrition 31, 1340–1346.CrossRefGoogle ScholarPubMed
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S. & Breslow, J. L. (1988). Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Journal of Clinical Investigation 82, 1884–1893.CrossRefGoogle ScholarPubMed
Wong, S. & Nestel, P. S. (1987). Eicosapentaenoic acid inhibits the secretion of triacylglycerol and of apoprotein B and the binding of LDL in HepG2 cells. Atherosclerosis 64, 139–146.CrossRefGoogle Scholar
Zilversmit, D. B. (1979). Atherogenesis: a postprandial phenomenon. Circulation 60, 473–485.CrossRefGoogle ScholarPubMed
Zucker, M. L., Bilyeu, D., Helmkamp, D. H., Harris, W. S. & Dujovne, C. A. (1988). Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. Atherosclerosis 73, 13–22.CrossRefGoogle ScholarPubMed