Chapters 16 presents the first of the two real-life multivariate biomarker discovery studies included in the book. The goal of this study – which implements the method presented in Chapters 14 and 15 – is to identify the essential gene expression patterns and a multivariate biomarker common for multiple types of cancer. This study is based on the TCGA RNA-Seq data of 3,528 patients and 20,530 gene expression variables; the data represent five tumor types of five different tissues. A parsimonious multivariate biomarker (consisting of ten genes) with high sensitivity and specificity has been identified.