A list of 50 optically observable O stars that are likely on or very near the ZAMS is presented. They have been selected on the basis of five distinct criteria, although some of them exhibit more than one. Three of the criteria are spectroscopic (He II λ4686 absorption stronger than in normal luminosity class V spectra, abnormally broad or strong Balmer lines, weak UV wind profiles for their spectral types), one is environmental (association with dense, dusty nebular knots), and one is photometric (derived absolute magnitudes fainter than class V). Very few of these stars have been physically analyzed, and they have not been considered in the current framework of early massive stellar evolution. In particular, they may indicate that the earliest, embedded phases are not as large a fraction of the main-sequence lifetimes as is currently believed. Detailed analyses of these objects will likely prove essential to a complete understanding of the early evolution of massive stars.