Gastrointestinal (GI) symptoms such as pain, heartburn, abdominal bloating, diarrhea, and constipation occur in most individuals at some time or another. Numerous diagnostic studies and medical interventions are available, but often the problems continue. Eager for relief, nearly half of all patients with chronic GI symptoms turn to the many “complementary” or “alternative” approaches available to the public [1]. This chapter reviews the options that have undergone testing, and summarizes those that are most likely to be of clinical benefit based on the quality of the studies. Many of the alternative approaches have undergone one form or another of clinical trial, but most often the data was either of poor quality or the studies were poorly controlled. Table 9.1 lists those approaches that are low risk and may be beneficial or have some supportive evidence. Table 9.2 lists those approaches that are clinically interesting but have insufficient supportive data to make a recommendation.