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Chapter 21 - ART and Oocyte Donation in Cancer Survivors

from Section 6 - Fertility Preservation Strategies in the Female: ART

Published online by Cambridge University Press:  27 March 2021

By
Glenn L Schattman ,
Ina N Cholst  and
Zev Rosenwaks
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Every year many women worldwide are diagnosed with cancer. More than 90% of cancer patients undergo invasive cancer therapy, such as chemo- and radiotherapy [1]. Most chemotherapy regimens include the alkylating agent cyclophosphamide, which is known to cause a significant loss in ovarian follicle reserve, and may result in infertility and early menopause. The irreversible destruction of germ cells after using both radio and chemotherapy is due to a direct apoptotic effect on oocytes [2]. On the other hand, advances in oncological treatments and better screening programs have significantly improved the life expectancy thus increasing the population of young cancer survivors. Therefore, protection against iatrogenic infertility caused by cancer therapies is considered indispensable to allow patients to have a chance to conceive in the future and to have their own genetic offspring.

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 225 - 242
Publisher: Cambridge University Press
Print publication year: 2021

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