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Mood disorders require consistent management of symptoms to prevent recurrences of mood episodes. Circadian rhythm (CR) disruption is a key symptom of mood disorders to be proactively managed to prevent mood episode recurrences. This study aims to predict impending mood episodes recurrences using digital phenotypes related to CR obtained from wearable devices and smartphones.
The study is a multicenter, nationwide, prospective, observational study with major depressive disorder, bipolar disorder I, and bipolar II disorder. A total of 495 patients were recruited from eight hospitals in South Korea. Patients were followed up for an average of 279.7 days (a total sample of 75 506 days) with wearable devices and smartphones and with clinical interviews conducted every 3 months. Algorithms predicting impending mood episodes were developed with machine learning. Algorithm-predicted mood episodes were then compared to those identified through face-to-face clinical interviews incorporating ecological momentary assessments of daily mood and energy.
Two hundred seventy mood episodes recurred in 135 subjects during the follow-up period. The prediction accuracies for impending major depressive episodes, manic episodes, and hypomanic episodes for the next 3 days were 90.1, 92.6, and 93.0%, with the area under the curve values of 0.937, 0.957, and 0.963, respectively.
We predicted the onset of mood episode recurrences exclusively using digital phenotypes. Specifically, phenotypes indicating CR misalignment contributed the most to the prediction of episodes recurrences. Our findings suggest that monitoring of CR using digital devices can be useful in preventing and treating mood disorders.
To propose a new anthropometric index that can be employed to better predict percent body fat (PBF) among young adults and to compare with current anthropometric indices.
All measurements were taken in a controlled laboratory setting in Seoul (South Korea), between 1 December 2015 and 30 June 2016.
Eighty-seven young adults (18–35 years) who underwent dual-energy x-ray absorptiometry (DXA) were used for analysis. Multiple regression analyses were conducted to develop a body fat index (BFI) using simple demographic and anthropometric information. Correlations of DXA measured PBF (DXA_PBF) with previously developed anthropometric indices and the BFI were analysed. Receiver operating characteristic curve analyses were conducted to compare the ability of anthropometric indices to identify obese individuals.
BFI showed a strong correlation with DXA_PBF (r = 0·84), which was higher than the correlations of DXA_PBF with the traditional (waist circumference, r = 0·49; waist to height ratio, r = 0·68; BMI, r = 0·36) and alternate anthropometric indices (a body shape index, r = 0·47; body roundness index, r = 0·68; body adiposity index, r = 0·70). Moreover, the BFI showed higher accuracy at identifying obese individuals (area under the curve (AUC) = 0·91), compared with the other anthropometric indices (AUC = 0·71–0·86).
The BFI can accurately predict DXA_PBF in young adults, using simple demographic and anthropometric information that are commonly available in research and clinical settings. However, larger representative studies are required to build on our findings.
The aim of this study is to develop predictive models to predict organ at risk (OAR) complication level, classification of OAR dose-volume and combination of this function with our in-house developed treatment decision support system.
Materials and methods
We analysed the support vector machine and decision tree algorithm for predicting OAR complication level and toxicity in order to integrate this function into our in-house radiation treatment planning decision support system. A total of 12 TomoTherapyTM treatment plans for prostate cancer were established, and a hundred modelled plans were generated to analyse the toxicity prediction for bladder and rectum.
The toxicity prediction algorithm analysis showed 91·0% accuracy in the training process. A scatter plot for bladder and rectum was obtained by 100 modelled plans and classification result derived. OAR complication level was analysed and risk factor for 25% bladder and 50% rectum was detected by decision tree. Therefore, it was shown that complication prediction of patients using big data-based clinical information is possible.
We verified the accuracy of the tested algorithm using prostate cancer cases. Side effects can be minimised by applying this predictive modelling algorithm with the planning decision support system for patient-specific radiotherapy planning.
Devastating disasters around the world directly contribute to significant increases in human mortality and economic costs. The objective of this study was to examine the current state of the Korea Disaster Relief Team that participated in an international training module.
The whole training period was videotaped in order to observe and evaluate the respondents. The survey was carried out after completion of the 3-day training, and the scores were reported by use of a 5-point Likert scale.
A total of 43 respondents were interviewed for the survey, and the results showed that the overall preparedness score for international disasters was 3.4±1.6 (mean±SD). The awareness of the Incident Command System for international disasters was shown to be low (3.5±1.1). Higher scores were given to personnel who took on leadership roles in the team and who answered “I knew my duty” (4.4±0.6) in the survey, as well as to the training participants who answered “I clearly knew my duty” (4.5±0.5).
The preparedness level of the Korea Disaster Relief Team was shown to be insufficient, whereas understanding of the roles of leaders and training participants in the rescue team was found to be high. It is assumed that the preparedness level for disaster relief must be improved through continued training. (Disaster Med Public Health Preparedness. 2016;1–5)
Perimesencephalic subarachnoid hemorrhage (PSH) is a relatively benign clinical entity with a low risk of recurrent bleeding. The precise etiology of PSH has not yet been determined. We report here three cases of PSH with clinical and radiological features that support a venous system as a cause.
The first patient, a 72-year-old woman, had PSH and venous hemorrhagic infarct in the left thalamus on non-contrast CT. Subsequent cerebral angiography revealed widespread thrombosis in the cerebral venous system, a potential cause for reflux overflow hemorrhage. The second patient, a 55-year-old man with an established diagnosis of neuro-Behçet's disease, a well-known cause for cerebral venulitis, presented with PSH one year later. The third patient, a 39-year-old female, with incomplete Behçet's disease was admitted with PSH.
Current concepts on the anatomic origin and the possible pathophysiologic mechanism leading to PSH are discussed. The underlying pathological conditions in the venous system in our cases provide theoretical clues to the anatomic origin of PSH in general.
It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders.
The relationship between BDV infection and schizophrenia with deficit syndrome was investigated.
Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40.
Results and conclusions:
BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.
The neurobiological mechanism of auditory hallucination (AH) in schizophrenia remains elusive, but AH can be caused by the abnormality in the speech perception system based on the speech perception neural network model.
The purpose of this study was to investigate whether schizophrenic patients with AH have the speech processing impairment as compared with schizophrenic patients without AH, and whether the speech perception ability could be improved after AH had subsided.
Twenty-four schizophrenic patients with AH were compared with 25 schizophrenic patients without AH. Narrative speech perception was assessed using a masked speech tracking (MST) task with three levels of superimposed phonetic noise. Sentence repetition task (SRT) and auditory continuous performance task (CPT) were used to assess grammar-dependent verbal working memory and non-language attention, respectively. These tests were measured before and after treatment in both groups.
Before treatment, schizophrenic patients with AH showed significant impairments in MST compared with those without AH. There were no significant differences in SRT and CPT correct (CPT-C) rates between both groups, but CPT incorrect (CPT-I) rate showed a significant difference. The low-score CPI-I group showed a significant difference in MST performance between the two groups, while the high-score CPI-I group did not. After treatment (after AH subsided), the hallucinating schizophrenic patients still had significant impairment in MST performance compared with non-hallucinating schizophrenic patients.
Our results support the claim that schizophrenic patients with AH are likely to have a disturbance of the speech perception system. Moreover, our data suggest that non-language attention might be a key factor influencing speech perception ability and that speech perception dysfunction might be a trait marker in schizophrenia with AH.
Recent extensive nanomechanical experiments have revealed that the instantaneous strength and plasticity of a material can be significantly affected by the size (of sample, microstructure, or stressed zone). One more important property to be added into the list of size-dependent properties is time-dependent plastic deformation referred to as creep; it has been reported that the creep becomes more active at the small scale. Analyzing the creep in the small scale can be valuable not only for solving scientific curiosity but also for obtaining practical engineering information about the lifetime or durability of advanced small-scale structures. For the purpose, nanoindentation creep experiments have been widely performed by far. Here we critically review the existing nanoindentation creep methods and the related issues and finally suggest possible novel ways to better estimate the small-scale creep properties.
We performed this study to investigate the effect of histone deacetylase inhibition during extended culture of in vitro matured mouse oocytes. In vitro matured mouse (BDF1) oocytes were cultured in vitro for 6, 12, and 24 h, respectively, and then inseminated. During in vitro culture for 6 and 12 h, two doses of trichostatin A (TSA), a histone deacetylase inhibitor, were added (100 nM and 500 nM) to the culture medium and the oocytes were then inseminated. During the 24-h in vitro culture, two doses of TSA were added (100 nM and 500 nM) to the medium and the oocytes were activated with 10 mM SrCl2. After the 6-h culture, the fertilization rate was similar to that of the control group, but the blastocyst formation rate was significantly decreased. After the 12-h culture, both the fertilization and blastocyst formation rates were significantly decreased. After the 24-h culture, total fertilization failure occurred. In the oocytes cultured for 6 and 12 h, the fertilization and blastocyst formation rates did not differ between the TSA-supplemented and control groups. Although extended culture of the mouse oocytes significantly affected their fertilization and embryo development, TSA supplementation did not overcome their decreased developmental potential.
To enhance the lifetime of large-sized active matrix organic light emitting
diodes (AMOLEDs), we developed a liquid desiccant for encapsulation. The
liquid desiccant was prepared by mixing nano-sized calcium oxide (CaO)
powders and silicone binder including polyalkylalkenylsiloxane,
polyalkylhydrogensiloxane and platinum compound. It was confirmed that
liquid desiccant had an effect on absorption of penetrated moisture and
oxygen through calcium tests. Also, the test cells encapsulated with only
epoxy sealant dispensed at the edge of the cell developed dark spots within
100 hrs, which grew larger with time at 85 oC and 85 % R.H. On the other hand, the test cell sealed with epoxy
sealant and liquid desiccant showed no dark spots and retained 97% of its
initial luminance even after being stored for 800 hrs at 85 oC and 85 % R.H. Furthermore, the accelerating storage lifetimes of
31-inch bottom-emitting AMOLEDs with epoxy sealant and liquid desiccant
showed about 1000 hrs. These results suggest that the liquid desiccant can
be applied to encapsulation of large-sized AMOLEDs.
This study aimed to investigate whether aquaporin 3 (Aqp3) mRNAs are expressed in immature oocytes and altered during in vitro maturation process. Five- to 6-week-old female ICR mice were primed by gonadotropin for 24 and 48 h. Immature oocytes obtained 48 h after priming were also matured in vitro for 17 to 18 h. In vivo matured oocytes were obtained after 48 h priming followed by hCG injection. Total RNAs were extracted from 80 to 150 oocytes in each experimental group, and the levels of Aqp3 mRNA were quantified by real-time reverse transcriptase polymerase chain reaction. The experiments were repeated twice using different oocytes. The Aqp3 mRNA was expressed in immature oocytes, as well as in in vitro and in vivo matured oocytes. The expression level was higher in immature oocytes obtained 48 h after priming (17.2 ± 8.6, mean ± SD) than those with no priming (5.7 ± 0.8) or obtained 24 h after priming (2.5 ± 0.8). The expression of Aqp3 mRNA decreased after in vitro maturation (1.2 ± 0.5), which was similar to in vivo matured oocytes (1.0 ± 0.0). Our work demonstrated that Aqp3 mRNA expression increased during the development of immature oocyte but decreased after completion of in vitro maturation. The results indicate that AQP3 is certainly needed for the acquisition of immature oocytes’ full growing potential within antral follicles.
In this study, we have investigated microencapsulation of magenta, yellow, and cyan color polymer balls with white pigment for multi-color electrophoretic display implementation. The charged color pigments have been prepared by physical coating of magenta, yellow, and cyan with functionalized polymers, then surface charging with charge control agent. These color balls with white pigment were microencapsulated in suspending fluid through in-situ polymerization.
The complex dielectric constants of several π-conjugated materials were measured, and generalized Langevin equation was used to analyze the dielectric behavior in the frequency domain. From the results of the fitting the experimental data using the generalized Langevin equation, we suggest that the charge carriers are electrically screened by the neighboring charges through the structural relaxation, and the carriers are not interact each other. We confirmed that the generalized Langevin equation offers a very good approach to analyze and understand the transport properties of charge carriers in π-conjugated materials.
We have investigated the growth mechanism and thin film morphology of pentacene thin films by the process of low-pressure gas assisted organic vapor deposition (LP-GAOVD). As the source temperature, flow rate of the carrier gas, substrate temperature and chamber pressure were varied, the growth rate, morphology and grain size of the films were differently obtained. The electrical properties of pentacene thin films for applications in organic thin film transistor and electrophoretic displays were discussed
AlxGa1-xN sample with x=0.36 was epitaxially grown on sapphire by MOCVD. SAW velocity of 5420 m/s and TCF (temperature coefficient of frequency) of -51.20 ppm/°C were measured from the SAW devices fabricated on the AlxGa1-xN sample, when kh value was 0.078, at temperatures between –30 °C and 60 °C Electromechanical coupling coefficient was ranged from 1.26 % to 2.22 %. The fabricated SAW filter have shown a good device performance with insertion loss of -33.853 dB and side lobe attenuation of 20 dB.
Boundary properties between two adjacent grains with different crystallographic orientation relation are important factors in deciding the mechanical properties of materials. in our previous reports, we introduced the geometric compatibility equation as a factor determining the brittle crack propagation condition into the adjacent grain in banitic low alloy steel as follows:
M = cos α · cos θ
where α is the angle between crack normal in the cracked grain-I and normal to (001) plane in the adjacent grain-II and θ is the angle between normal to (001) plane in the grain II and loading axis.(see FIG. 1) Higher M gives greater possibility to the crack propagation. The geometric compatibility factor (M) could be easily calculated from the crystallographic data obtained from Electron Backscatter Diffraction (EBSD) analysis, and successfully predicted actual crack propagation plane. We also found that there was a critical M value to arrest the brittle crack propagation at the boundaries.
YMnO3 thin films were sputtered on Si (100) substrates under different ambient conditions. After rapid thermal annealing process at 850 °C, the YMnO3 film deposited in Ar ambient had random orientations and the YMnO3 film deposited in Ar+O2 ambient was crystallized with distinct two layers, i.e., c-axis oriented layer in top region and random oriented layer in bottom region. Relations between the microstructure and the electrical properties of Pt/YMnO3/Si capacitor were investigated. Memory window and leakage current depended on the orientation of the YMnO3 thin films and the interfacial microstructure of the YMnO3/Si, respectively
The YSTAR program is a general sky survey looking for variability. The main equipments are three 0.5-m telescopes. These telescopes have fast F/2 optics covering nearly 3.5 square degree field onto a 2K CCD. They also have very fast slew capability, which exceeds 10 degrees per second. These two factors make them most suitable for rapid target acquisition and wide-field surveys of various kinds. Our primary objective is to identify and monitor variable stars down to 18th R-magnitude, and our observing mode allows the same data set to be also useful in identifying asteroids. Our first telescope has just begun regular automated operation, and the second telescope will be installed in South Africa within this year to provide coverage of the southern sky.
The purpose of the present study was to characterize the Ca2+ channels in smooth
muscle cells from human stomach and to examine the effects of osmotic swelling on
the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier
was recorded from freshly isolated smooth muscle cells using the conventional
whole-cell patch clamp technique. The degree of cell swelling as a result of hypotonic
challenge was monitored using a video image analysis system. The changes in
intracellular Ca2+ concentration ([Ca2+]i) were measured by microfluorimetry. The
pharmacological and voltage activation profile suggests a typical
dihydropyridine-sensitive L-type Ca2+ current. Cell swelling, induced by hypotonic
challenge, enhanced the amplitude of currents through L-type Ca2+ channels without
significant effects on steady-state voltage dependency. After treatment with the
L-type Ca2+ channel agonist Bay K 8644 (0.1-2 µM), no further significant increase in
calcium channel current or corresponding [Ca2+]i transients were provoked by the
swelling. The above results demonstrated that the presence of L-type Ca2+ current in
smooth muscle cells of the human stomach and the augmentation of the current are
closely associated with the volume increase resulting from hypotonic swelling.
Experimental Physiology (2000) 85.5, 497-504.
Boundary properties between two adjacent grains with different crystallographic orientation relation are important factors in deciding the mechanical properties of materials. The concept of the geometric compatibility factor has been introduced in order to explain the relationship between transfer of deformation mode and crystal orientation. In the same manner, when the brittle crack propagates, grain boundary also obstructs crack propagation. Therefore it is also possible to introduce the concept of geometric compatibility considering the crystallographic orientation in analyzing the crack propagation.
In this study, the characteristics of the brittle crack propagation in bainitic low alloy steel with compositions shown in table 1 have been investigated using EBSD analysis. A 3-point bending test was performed at -100°C and the secondary crack below fracture surface was analyzed in relation to the crystallographic orientation. In order to explain the behavior of crack propagation, modified geometric compatibility factor, M was introduced considering loading axis and crystallographic orientation relationship.