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Chapter 35 - Neurological and Long-Term Neurodevelopmental Outcome after Fetal Therapy in Complicated Monochorionic Twins

from Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome

Published online by Cambridge University Press:  21 October 2019

By
Jeanine van Klink ,
Marjolijn S. Spruijt  and
Enrico Lopriore
Edited by
Mark D. Kilby ,
Anthony Johnson  and
Dick Oepkes
Mark D. Kilby
Affiliation:
University of Birmingham
Anthony Johnson
Affiliation:
University of Texas Medical School at Houston
Dick Oepkes
Affiliation:
Leids Universitair Medisch Centrum
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Summary

An increasing number of monochorionic (MC) twin pregnancy complications are being detected prior to birth due to major improvements in prenatal ultrasound examinations [1]. For various MC twin complications, fetal therapy is a life-saving option or an alternative to postnatal treatment to prevent permanent organ damage, including damage to the developing fetal brain. The aim of this chapter is threefold: to summarize current knowledge on the neurological and neurodevelopmental outcome after fetal therapy in complicated MC twin pregnancies; to identify risk factors for adverse long-term outcome; and to provide future research and care suggestions.

Type
Chapter
Information
Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
 , pp. 373 - 383
Publisher: Cambridge University Press
Print publication year: 2020

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References

Deprest, J, Jani, J, Lewi, L, et al. Fetoscopic surgery: encouraged by clinical experience and boosted by instrument innovation. Semin Fetal Neonatal Med. 2006; 11: 398–412.Google Scholar
Rossi, AC, D’Addario, V. Laser therapy and serial amnioreduction as treatment for twin-twin transfusion syndrome: a meta-analysis and review of literature. Am J Obstet Gynecol. 2008; 198: 147–52.CrossRefGoogle ScholarPubMed
van Klink, JMM, Koopman, HM, van Zwet, EW, et al. Cerebral injury and neurodevelopmental impairment after amnioreduction versus laser surgery in twin-twin transfusion syndrome: a systematic review and meta-analysis. Fetal Diagn Ther. 2013; 33: 81–9.CrossRefGoogle ScholarPubMed
Senat, MV, Deprest, J, Boulvain, M, et al. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. New Engl J Med. 2004; 351: 136–44.Google Scholar
Slaghekke, F, Lopriore, E, Lewi, L, et al. Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome: an open-label randomised controlled trial. Lancet. 2014; 383: 2144–51.CrossRefGoogle ScholarPubMed
van Klink, JM, Koopman, HM, Rijken, M, et al. Long-term neurodevelopmental outcome in survivors of twin-to-twin transfusion syndrome. Twin Res Hum Genet. 2016; 19: 255–61.CrossRefGoogle ScholarPubMed
Stirnemann, J, Chalouhi, G, Essaoui, M, et al. Fetal brain imaging following laser surgery in twin-to-twin surgery. BJOG. 2016; 125: 1186–91.Google ScholarPubMed
Lopriore, E, van Wezel-Meijler, G, Middeldorp, JM, et al. Incidence, origin, and character of cerebral injury in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery. Am J Obstet Gynecol. 2006; 194: 1215–20.CrossRefGoogle ScholarPubMed
Salomon, LJ, Ortqvist, L, Aegerter, P, et al. Long-term developmental follow-up of infants who participated in a randomized clinical trial of amniocentesis vs laser photocoagulation for the treatment of twin-to-twin transfusion syndrome. Am J Obstet Gynecol. 2010; 203: 444. e1–7.CrossRefGoogle Scholar
Tosello, B, Blanc, J, Haumonté, JB, D'Ercole, C, Gire, C. Short and medium-term outcomes of live-born twins after fetoscopic laser therapy for twin-twin transfusion syndrome. J Perinat Med. 2014; 42: 99–105.CrossRefGoogle Scholar
Mullers, SM, McAuliffe, FM, Kent, E, et al. Outcome following selective fetoscopic laser ablation for twin to twin transfusion syndrome: an 8 year national collaborative experience. Eur J Obstet Gynecol Reprod Biol. 2015; 191: 125–9.CrossRefGoogle ScholarPubMed
Campos, D, Arias, AV, Campos-Zanelli, TM, et al. Twin-twin transfusion syndrome: neurodevelopment of infants treated with laser surgery. Arq Neuropsiquiatr. 2016; 74: 307–13.CrossRefGoogle ScholarPubMed
Lopriore, E, Ortibus, E, Acosta-Rojas, R, et al. Risk factors for neurodevelopment impairment in twin-twin transfusion syndrome treated with fetoscopic laser surgery. Obstet Gynecol. 2009; 113: 361–6.Google Scholar
van Klink, JM, Slaghekke, F, Balestriero, MA, et al. Neurodevelopmental outcome at 2 years in twin-twin transfusion syndrome survivors randomized for the Solomon trial. Am J Obstet Gynecol. 2015; 214: 113. e1–7.Google ScholarPubMed
Slaghekke, F, van Klink, JM, Koopman, HM, et al. Neurodevelopmental outcome in twin anemia-polycythemia sequence after laser surgery for twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2014; 44: 316–21.CrossRefGoogle ScholarPubMed
Taniguchi, K, Sumie, M, Sugibayashi, R, et al. Twin anemia-polycythemia sequence after laser surgery for twin-twin transfusion syndrome and maternal morbidity. Fetal Diagn Ther. 2015; 37: 148–53.Google Scholar
Ashwal, E, Yinon, Y, Fishel-Bartal, M, et al. Twin Anemia-Polycythemia Sequence: perinatal Management and Outcome. Fetal Diagn Ther. 2016; 40: 28–34.CrossRefGoogle ScholarPubMed
Tollenaar, LS, Slaghekke, F, Middeldorp, JM, et al. Twin anemia polycythemia sequence: current views on pathogenesis, diagnostic criteria, perinatal management, and outcome. Twin Res Hum Genet. 2016; 19: 222–33.Google Scholar
Lopriore, E, Sluimers, C, Pasman, SA, et al. Neonatal morbidity in growth-discordant monochorionic twins: comparison between the larger and the smaller twin. Twin Res Hum Genet. 2012; 15: 541–6.CrossRefGoogle ScholarPubMed
Inklaar, MJ, van Klink, JM, Stolk, TT, et al. Cerebral injury in monochorionic twins with selective intrauterine growth restriction: a systematic review. Prenat Diagn. 2014; 34: 205–13.CrossRefGoogle ScholarPubMed
Swamy, RS, McConachie, H, Ng, J, et al. Cognitive outcome in childhood of birth weight discordant monochorionic twins: the long-term effects of fetal growth restriction. Arch Dis Child Fetal Neonatal Ed. 2018; 103: F512–16.Google Scholar
Edmonds, CJ, Isaacs, EB, Cole, TJ, et al. The effect of intrauterine growth on verbal IQ scores in childhood: a study of monozygotic twins. Pediatrics. 2010; 126: e1095–101.Google Scholar
Barker, DJ. Adult consequences of fetal growth restriction. Clin Obstet Gynecol. 2006; 49: 270–83.Google Scholar
Gluckman, PD, Hanson, MA, Cooper, C, Thornburg, KL. Effect of in utero and early-life conditions on adult health and disease. New Engl J Med. 2008; 359: 61–73.Google Scholar
Heijmans, BT, Tobi, EW, Stein, AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008; 105: 17046–9.Google Scholar
Rossi, AC, D’Addario, V. Umbilical cord occlusion for selective feticide in complicated monochorionic twins:a systematic review of the literature. Am J Obstet Gynecol. 2009; 200: 123–9.CrossRefGoogle Scholar
van den Bos, EM, van Klink, JM, Middeldorp, JM et al. Perinatal outcome after selective feticide in monochorionic twin pregnancies. Ultrasound Obstet Gynecol. 2013; 41: 653–8.Google Scholar
Robyr, R, Yamamoto, M, Ville, Y. Selective feticide in complicated monochorionic twin pregnancies using ultrasound-guided bipolar cord coagulation. BJOG. 2005; 112: 1344–8.Google Scholar
Lewi, L, Gratacós, E, Ortibus, E, et al. Pregnancy and infant outcome of 80 consecutive cord coagulations in complicated monochorionic multiple pregnancies. Am J Obstet Gynecol. 2006; 194: 782–9.Google Scholar
Moise, KJ Jr., Johnson, A, Moise, KY, Nickeleit, V. Radiofrequency ablation for selective reduction in the complicated monochorionic gestation. Am J Obstet Gynecol. 2008; 198: 198. e1–198. e5.Google Scholar
Delabaere, A, Favre, N, Velemir, L, et al. Pediatric outcome after selective feticide for 30 complicated monochorionic twin pregnancies. Gynecol Obstet Fertil. 2013; 41: 85–9.Google Scholar
van Klink, JM, Koopman, HM, Middeldorp, JM, et al. Long-term neurodevelopmental outcome after selective feticide in monochorionic pregnancies. BJOG. 2015; 122: 1517–24.Google Scholar
Wang, HM, Li, HY, Wang, XT, et al. Radiofrequency ablation for selective reduction in complex monochorionic multiple pregnancies: A case series. Taiwan J Obstet Gynecol. 2017; 56: 740–4.CrossRefGoogle ScholarPubMed
Hillman, SC, Morris, RK, Kilby, MD. Co-twin prognosis after single fetal death. A systematic review and meta-analysis. Obstet Gynecol. 2011; 118: 928–40.Google Scholar
van Klink, JM, van Steenis, A, Steggerda, SJ, et al. Single fetal demise in monochorionic pregnancies: incidence and patterns of cerebral injury. Ultrasound Obstet Gynecol. 2015; 45: 294–300.Google Scholar
Conte, G, Righini, A, Griffiths, PD, et al. Brain-injured survivors of monochorionic twin pregnancies complicated by single intrauterine death: MR findings in a multicenter study. Radiology. 2018; 288: 582–90.Google Scholar
O’Donoghue, K, Barigye, O, Pasquini, L, et al. Interstitial laser therapy for fetal reduction in monochorionic multiple pregnancy: loss rate and association with aplasia cutis congenita. Prenat. Diagn. 2008; 28: 535–43.Google Scholar
Mackie, FL, Morris, RK, Kilby, MD. Fetal brain injury in survivors of twin pregnancies complicated by demise of one twin: a review. Twin Res Hum Genet. 2016; 19: 262–7.Google Scholar
Aylward, GP, Hatcher, RP, Stripp, B, Gustafson, NF, Leavitt, LA. Who goes and who stays: subject loss in a multicenter, longitudinal follow-up study. J Dev Behav Pediatr. 1985; 6: 3–8.Google Scholar
Wolke, D, Söhne, B, Ohrt, B, Riegel, K. Follow-up of preterm children: important to document dropouts. Lancet. 1995; 345: 447.CrossRefGoogle ScholarPubMed
Reisner, DP, Mahony, BS, Petty, CN, et al. Stuck twin syndrome: outcome in thirty-seven consecutive cases. Am J Obstet Gynecol. 1993; 169: 991–5.Google Scholar
Mari, G, Detti, L, Oz, U, Abuhamad, AZ. Long-term outcome in twin-twin transfusion syndrome treated with serial aggressive amnioreduction. Am J Obstet Gynecol. 2000; 183: 211–17.Google Scholar
Cincotta, RB, Gray, PH, Phythian, G, Rogers, YM, Chan, FY. Long term outcome of twin-twin transfusion syndrome. Arch Dis Child Fetal Neonatal Ed. 2000; 83: F171–6.Google Scholar
Haverkamp, F, Lex, C, Hanisch, C, Fahnenstich, H, Zerres, K. Neurodevelopmental risks in twin-to-twin transfusion syndrome: preliminary findings. Eur J Paediatr Neurol. 2001; 5: 21–7.Google Scholar
Frusca, T, Soregaroli, M, Fichera, A, et al. Pregnancies complicated by twin-twin transfusion syndrome: outcome and long-term neurological follow-up. Eur J Obstet Gynecol Reprod Biol. 2003; 107: 145–50.Google Scholar
Lopriore, E, Middeldorp, JM, Sueters, M, et al. Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery. Am J Obstet Gynecol. 2007; 196: 231. e1–4.Google ScholarPubMed
Dickinson, JE, Duncombe, GJ, Evans, SF, French, NP, Hagan, R. The long term neurologic outcome of children from pregnancies complicated by twin-to-twin transfusion syndrome. BJOG. 2005; 112: 63–8.CrossRefGoogle Scholar
Lenclen, R, Ciarlo, G, Paupe, A, Bussieres, L, Ville, Y. Neurodevelopmental outcome at 2 years in children born preterm treated by amnioreduction or fetoscopic laser surgery for twin-to-twin transfusion syndrome: comparison with dichorionic twins. Am J Obstet Gynecol. 2009; 201: 291. e1–5.Google Scholar
Li, X, Morokuma, S, Fukushima, K, et al. Prognosis and long-term neurodevelopmental outcome in conservatively treated twin-to-twin transfusion syndrome. BMC Pregnancy Childbirth. 2011; 11: 32.Google Scholar
De Lia, JE, Kuhlmann, RS, Lopez, KP. Treating previable twin-twin transfusion syndrome with fetoscopic laser surgery: outcomes following the learning curve. J Perinat Med. 1999; 27: 61–7.CrossRefGoogle ScholarPubMed
Sutcliffe, AG, Sebire, NJ, Pigott, AJ, et al. Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome. BJOG. 2001; 108: 1246–50.Google Scholar
Banek, CS, Hecher, K, Hackeloer, BJ, Bartmann, P. Long-term neurodevelopmental outcome after intrauterine laser treatment for severe twin-twin transfusion syndrome. Am J Obstet Gynecol. 2003; 188: 876–80.Google Scholar
Graef, C, Ellenrieder, B, Hecher, K, et al. Long-term neurodevelopmental outcome of 167 children after intrauterine laser treatment for severe twin-twin transfusion syndrome. Am J Obstet Gynecol. 2006; 194: 303–8.Google Scholar
Gray, PH, Poulsen, L, Gilshenan, K, et al. Neurodevelopmental outcome and risk factors for disability for twin-twin transfusion syndrome treated with laser surgery. Am J Obstet Gynecol. 2011; 204: 159. e1–6.Google Scholar
Chang, YL, Chao, AS, Chang, SD, et al. The neurological outcomes of surviving twins in severe twin-twin transfusion syndrome treated by fetoscopic laser photocoagulation at a newly established center. Prenat Diagn. 2012; 32: 893–6.Google Scholar
Graeve, P, Banek, C, Stegmann-Woessner, G, et al. Neurodevelopmental outcome at 6 years of age after intrauterine laser therapy for twin-twin transfusion syndrome. Acta Paediatr. 2012; 101: 1200–5.CrossRefGoogle ScholarPubMed
McIntosh, J, Meriki, N, Joshi, A, et al. Long term developmental outcomes of pre-school age children following laser surgery for twin-to-twin transfusion syndrome. Early Hum Dev. 2014; 90: 837–42.Google Scholar
Vanderbilt, DL, Schrager, SM, Llanes, A, et al. Predictors of 2-year cognitive performance after laser surgery for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2014; 211: 388. e1–7.Google Scholar
Sananes, N, Gabriele, V, Weingertner, AS, et al. Evaluation of long-term neurodevelopment in twin-twin transfusion syndrome after laser therapy. Prenat Diagn. 2016; 36: 1139–45.Google Scholar
van Klink, JM, Koopman, HM, van Zwet, EW, et al. Improvement in neurodevelopmental outcome in survivors of twin-twin transfusion syndrome treated with laser surgery. Am J Obstet Gynecol. 2014; 210: 540. e1–7.Google Scholar
Adegbite, AL, Castille, S, Ward, S, Bajoria, R. Neuromorbidity in preterm twins in relation to chorionicity and discordant birth weight. Am J Obstet Gynecol. 2004; 190: 156–63.Google Scholar
Hack, KE, Koopman-Esseboomet, C, Derks, JB, et al. Long-term neurodevelopmental outcome of monochorionic and matched dichorionic twins. PLoS ONE. 2009; 4: e6815.CrossRefGoogle ScholarPubMed
Halling, C, Malone, FD, Breathnach, FM, et al. Neuro-developmental outcome of a large cohort of growth discordant twins. Eur J Pediatr. 2016; 175: 381–9.Google Scholar
Vedel, C, Oldenburg, A, Worda, K, et al. Short- and long-term perinatal outcome in twin pregnancies affected by weight discordance. Acta Obstet Gynecol Scand. 2017; 96: 233–42.Google Scholar
Rustico, MA, Consonni, D, Lanna, M, et al. Selective intrauterine growth restriction in monochorionic twins: changing patterns in umbilical artery Doppler flow and outcomes. Ultrasound Obstet Gynecol. 2017; 49: 387–93.Google Scholar
Lanna, MM, Rustico, MA, Dell’Avanzo, M, et al. Bipolar cord coagulation for selective feticide in complicated monochorionic twin pregnancies: 118 consecutive cases at a single center. Ultrasound Obstet Gynecol. 2012; 39: 407–13.Google Scholar

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