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Fetal Dysrhythmias

from Section 2: - Fetal Disease: Pathogenesis and Treatment

Published online by Cambridge University Press:  21 October 2019

Mark D. Kilby
Affiliation:
University of Birmingham
Anthony Johnson
Affiliation:
University of Texas Medical School at Houston
Dick Oepkes
Affiliation:
Leids Universitair Medisch Centrum
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Summary

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Chapter
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Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
, pp. 166 - 190
Publisher: Cambridge University Press
Print publication year: 2020

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References

References

Naheed, ZJ, Strasburger, JF, Deal, BJ, Benson, DW Jr., Gidding, SS. Fetal tachycardia: mechanisms and predictors of hydrops fetalis. J Am Coll Cardiol. 1996; 27: 1736–40.Google Scholar
Artman, M, Coetzee, W. Developmental regulation of cardiac ion channels. In Zipes, D, Jalife, J, eds., Cardiac Electrophysiology: From Cell to Bedside. Philadelphia, PA: Saunders Elsevier, 2009, pp. 157–68.Google Scholar
Creazzo, T. Functional developmental biology of the myocardium. In Loewy Kirby, M, ed., Cardiac Development. New York: Oxford University Press, 2007, pp. 5368.Google Scholar
Friedman, WF. The intrinsic physiologic properties of the developing heart. Prog Cardiovasc Dis. 1972; 15: 87111.Google Scholar
Romero, T, Covell, J, Friedman, WF. A comparison of pressure-volume relations of the fetal, newborn, and adult heart. Am J Physiol. 1972; 222: 1285–90.CrossRefGoogle ScholarPubMed
Schmidt, MR, Kristiansen, SB, White, P, Smerup, M, Bøtker, HE, Vogel, M, Hjortdal, V, Sørensen, K, Redington, A. Glucose-insulin infusion improves cardiac function during fetal tachycardia. J Am Coll Cardiol. 2004; 43: 445–52.CrossRefGoogle ScholarPubMed
Vanoli, E, Cerati, D, Pedretti, RF. Autonomic control of heart rate: pharmacological and nonpharmacological modulation. Basic Res Cardiol. 1998; 93 (Suppl. 1): 133–42.Google Scholar
Rudolph, AM, Heymann, MA. Cardiac output in the fetal lamb: the effects of spontaneous and induced changes of heart rate on right and left ventricular output. Am J Obstet Gynecol. 1976; 124: 183–92.CrossRefGoogle ScholarPubMed
Reed, KL, Appleton, CP, Anderson, CF, Shenker, L, Sahn, DJ. Doppler studies of vena cava flows in human fetuses. Insights into normal and abnormal cardiac physiology. Circulation. 1990; 81: 498505.Google Scholar
Brace, RA. Effects of outflow pressure on fetal lymph flow. Am J Obstet Gynecol. 1989; 160: 494–7.CrossRefGoogle ScholarPubMed
Rudolph, A. The fetal circulation and postnatal adaptation. In Rudolph, A, ed., Congenital Diseases of the Heart. Armonk, NY: Future Publishing Company, 2001, pp. 344Google Scholar
Schmidt, KG, Ulmer, HE, Silverman, NH, Kleinman, CS, Copel, JA. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol. 1991; 17: 1360–6.CrossRefGoogle ScholarPubMed
Simpson, JM, Sharland, GK. Fetal tachycardias: management and outcome of 127 consecutive cases. Heart. 1998; 79: 576–81.Google Scholar
Jaeggi, E, Fouron, JC, Drblik, SP. Fetal atrial flutter: diagnosis, clinical features, treatment, and outcome. J Pediatr. 1998; 132: 335–9.Google Scholar
Jaeggi, ET, Carvalho, JS, De Groot, E, Api, O, Clur, SA, Rammeloo, L, McCrindle BW, , Ryan, G, Manlhiot, C, Blom, NA. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation. 2011; 124: 1747–54.Google Scholar
Wacker-Gussmann, A, Strasburger, JF, Srinivasan, S, Cuneo, BF, Lutter, W, Wakai, RT. Fetal atrial flutter: electrophysiology and associations with rhythms involving an accessory pathway. J Am Heart Assoc. 2016; 5: e003673.Google Scholar
Kleinman, CS, Donnerstein, RL, Jaffe, CC, DeVore, GR, Weinstein, EM, Lynch, DC, Talner, NS, Berkowitz, RL, Hobbins, JC. Fetal echocardiography. A tool for evaluation of in utero cardiac arrhythmias and monitoring of in utero therapy: analysis of 71 patients. Am J Cardiol. 1983; 51: 237–43.Google Scholar
Jaeggi, E, Fouron, JC, Fournier, A, van Doesburg, N, Drblik, SP, Proulx, F. Ventriculo-atrial time interval measured on M mode echocardiography: a determining element in diagnosis, treatment, and prognosis of fetal supraventricular tachycardia. Heart. 1998; 79: 582–7.Google Scholar
Fouron, JC, Fournier, A, Proulx, F, Lamarche, J, Bigras, JL, Boutin, C, Brassard, M, Gamache, S. Management of fetal tachyarrhythmia based on superior vena cava/aorta Doppler flow recordings. Heart. 2003; 89: 1211–16.Google Scholar
Donofrio, MT, Moon-Grady, AJ, Hornberger, LK, Copel, JA, Sklansky, MS, Abuhamad, A, et al. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation. 2014; 129: 2183–242.Google Scholar
Kleinman, CS, Copel, JA, Weinstein, EM, Santulli, TV Jr., Hobbins, JC. Treatment of fetal supraventricular tachyarrhythmias. J Clin Ultrasound. 1985; 13: 265–73.Google Scholar
van Engelen, AD, Weijtens, O, Brenner, JI, Kleinman, CS, Copel, JA, Stoutenbeek, P, Meijboom, EJ. Management outcome and follow-up of fetal tachycardia. J Am Coll Cardiol. 1994; 24: 1371–5.Google Scholar
Frohn-Mulder, IM, Stewart, PA, Witsenburg, M, Den Hollander, NS, Wladimiroff, JW, Hess, J. The efficacy of flecainide versus digoxin in the management of fetal supraventricular tachycardia. Prenat Diagn. 1995; 15: 1297–302.Google Scholar
Ebenroth, ES, Cordes, TM, Darragh, RK. Second-line treatment of fetal supraventricular tachycardia using flecainide acetate. Pediatr Cardiol. 2001; 22: 483–7.Google Scholar
Jouannic, JM, Delahaye, S, Fermont, L, Le Bidois, J, Villain, E, Dumez, Y, Dommerques, M. Fetal supraventricular tachycardia: a role for amiodarone as second-line therapy? Prenat Diagn. 2003; 23: 152–6.Google Scholar
Sridharan, S, Sullivan, I, Tomek, V, Wolfenden, J, Škovranek, J, Yates, R, Janoušek, J, Dominguez, TE, Marek, J. Flecainide versus digoxin for fetal supraventricular tachycardia: comparison of two drug treatment protocols. Heart Rhythm. 2016; 13: 1913–19.Google Scholar
Ekman-Joelsson, BM, Mellander, M, Lagnefeldt, L, Sonesson, SE. Foetal tachyarrhythmia treatment remains challenging even if the vast majority of cases have a favourable outcome. Acta Paediatr. 2015; 104: 1090–7.Google Scholar
Hill, GD, Kovach, JR, Saudek, DE, Singh, AK, Wehrheim, K, Frommelt, MA. Transplacental treatment of fetal tachycardia: a systematic review and meta-analysis. Prenat Diagn. 2017; 37: 1076–83.Google Scholar
Allan, LD, Chita, SK, Sharland, GK, Maxwell, D, Priestley, K. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991; 65: 46–8.Google Scholar
Barjot, P, Hamel, P, Calmelet, P, Maragnes, P, Herlicoviez, M. Flecainide against fetal supraventricular tachycardia complicated by hydrops fetalis. Acta Obstet Gynecol Scand. 1998; 77: 353–8.Google Scholar
Strizek, B, Berg, C, Gottschalk, I, Herberg, U, Geipel, A, Gembruch, U. High-dose flecainide is the most effective treatment of fetal supraventricular tachycardia. Heart Rhythm. 2016; 13: 1283–8.Google Scholar
Ekiz, A, Kaya, B, Bornaun, H, Acar, DK, Avci, ME, Bestel, A, Yildirim, G. Flecainide as first-line treatment for fetal supraventricular tachycardia. J Matern Fetal Neonatal Med. 2018: 31: 407–12.Google Scholar
Sonesson, SE, Fouron, JC, Wesslen-Eriksson, E, Jaeggi, E, Winberg, P. Foetal supraventricular tachycardia treated with sotalol. Acta Paediatr. 1998; 87: 584–7.Google Scholar
Oudijk, MA, Michon, MM, Kleinman, CS, Kapusta, L, Stoutenbeek, P, Visser, GH, Meijboom, EJ. Sotalol in the treatment of fetal dysrhythmias. Circulation. 2000; 101: 2721–6.Google Scholar
Oudijk, MA, Ruskamp, JM, Ververs, FF, Ambachtsheer, EB, Stoutenbeek, P, Visser, GH, Meijboom, EJ. Treatment of fetal tachycardia with sotalol: transplacental pharmacokinetics and pharmacodynamics. J Am Coll Cardiol. 2003; 42: 765–70.Google Scholar
Shah, A, Moon-Grady, A, Bhogal, N, Collins, KK, Tacy, T, Brook, M, Hornberger, LK. Effectiveness of sotalol as first-line therapy for fetal supraventricular tachyarrhythmias. Am J Cardiol. 2012; 109: 1614–18.Google Scholar
van der Heijden, LB, Oudijk, MA, Manten, GT, ter Heide, H, Pistorius, L, Freund, MW. Sotalol as first-line treatment for fetal tachycardia and neonatal follow-up. Ultrasound Obstet Gynecol. 2013; 42: 285–93.Google Scholar
Uzun, O, Babaoglu, K, Sinha, A, Massias, S, Beattie, B. Rapid control of foetal supraventricular tachycardia with digoxin and flecainide combination treatment. Cardiol Young. 2012; 22: 372–80.Google Scholar
Strasburger, JF, Cuneo, BF, Michon, MM, Gotteiner, NL, Deal, BJ, McGregor, SN, Oudijk, MA, Meijboom, EJ, Feinkind, L, Hussey, M, Parilla, BV. Amiodarone therapy for drug-refractory fetal tachycardia. Circulation. 2004; 109: 375–9.Google Scholar
Krapp, M, Baschat, AA, Gembruch, U, Geipel, A, Germer, U. Flecainide in the intrauterine treatment of fetal supraventricular tachycardia. Ultrasound Obstet Gynecol. 2002; 19: 158–64.Google Scholar
Hansmann, M, Gembruch, U, Bald, R, Manz, M, Redel, DA. Fetal tachyarrhythmias: transplacental and direct treatment of the fetus – a report of 60 cases. Ultrasound Obstet Gynecol. 1991; 1: 162–8.Google Scholar
Parilla, BV, Strasburger, JF, Socol, ML. Fetal supraventricular tachycardia complicated by hydrops fetalis: a role for direct fetal intramuscular therapy. Am J Perinatol. 1996; 13: 483–6.Google Scholar
Moatassim, S, Touleimat, S, Hazelzet, T, Brasseur, MD, Diguet, A, Durand, I, Verspyck, E. Maternal complications induced by digoxin treatment of fetal tachycardia: a retrospective series of 18 cases. J Gynecol Obstet Hum Reprod. 2018; 47: 35–8.Google Scholar
Bourget, P, Pons, JC, Delouis, C, Fermont, L, Frydman, R. Flecainide distribution, transplacental passage, and accumulation in the amniotic fluid during the third trimester of pregnancy. Ann Pharmacother. 1994; 28: 1031–4.Google Scholar
Hopson, JR, Buxton, AE, Rinkenberger, RL, Nademanee, K, Heilman, JM, Kienzle, MG. Safety and utility of flecainide acetate in the routine care of patients with supraventricular tachyarrhythmias: results of a multicenter trial. The Flecainide Supraventricular Tachycardia Study Group. Am J Cardiol. 1996; 77: 72A82A.Google Scholar
Hohnloser, SH, Woosley, RL. Sotalol. N Engl J Med. 1994; 331: 31–8.Google Scholar
Peralta, AO, John, RM, Gaasch, WH, Taggart, PI, Martin, DT, Venditti, FJ. The class III antiarrhythmic effect of sotalol exerts a reverse use-dependent positive inotropic effect in the intact canine heart. J Am Coll Cardiol. 2000; 36: 1404–10.CrossRefGoogle ScholarPubMed
Arnoux, P, Seyral, P, Llurens, M, Djiane, P, Potier, A, Unal, D, Cano, JP, Serradimigni, A, Rouault, F. Amiodarone and digoxin for refractory fetal tachycardia. Am J Cardiol. 1987; 59: 166–7.Google Scholar
Gembruch, U, Manz, M, Bald, R, Rüddel, H, Redel, DA, Schlebusch, H, Nitsch, J, Hansmann, M. Repeated intravascular treatment with amiodarone in a fetus with refractory supraventricular tachycardia and hydrops fetalis. Am Heart J. 1989; 118: 1335–8.Google Scholar
Bartalena, L, Bogazzi, F, Braverman, LE, Martino, E. Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment. J Endocrinol Invest. 2001; 24: 116–30.Google Scholar
Magee, LA, Nulman, I, Rovet, JF, Koren, G. Neurodevelopment after in utero amiodarone exposure. Neurotoxicol Teratol. 1999; 21: 261–5.Google Scholar
Vanbesien, J, Casteels, A, Bougatef, A, De Catte, L, Foulon, W, De Bock, S, Smitz, J, De Schepper, J. Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia. Am J Perinatol. 2001; 18: 113–16.Google Scholar
Gembruch, U, Hansmann, M, Redel, DA, Bald, R. Intrauterine therapy of fetal tachyarrhythmias: intraperitoneal administration of antiarrhythmic drugs to the fetus in fetal tachyarrhythmias with severe hydrops fetalis. J Perinat Med. 1988; 16: 3944.Google Scholar
Gembruch, U, Manz, M, Bald, R, Ruddel, H, Redel, DA, Schlebusch, H, Nitsch, J, Hansmann, M. Repeated intravascular treatment with amiodarone in a fetus with refractory supraventricular tachycardia and hydrops fetalis. Am Heart J. 1989; 118: 1335–8.Google Scholar

References

Glickstein, JS, Buyon, J, Friedman, D. Pulsed Doppler echocardiographic assessment of the fetal PR interval. Am J Cardiol. 2000; 86: 236–9.Google Scholar
Fouron, JC, Fournier, A, Proulx, F, et al. Management of fetal tachyarrhythmia based on superior vena cava/aorta Doppler flow recordings. Heart. 2003; 89: 1211–16.Google Scholar
Carvalho, JS, Prefumo, F, Ciardelli, V, et al. Evaluation of fetal arrhythmias from simultaneous pulsed wave Doppler in pulmonary artery and vein. Heart. 2007; 93: 1448–53.Google Scholar
Wacker-Gussmann, A, Plankl, C, Sewald, M, et al. Fetal cardiac time intervals in healthy pregnancies – an observational study by fetal ECG (Monica Healthcare System). J Perin Medicine. 2017; 46: 587–92.Google Scholar
Wacker-Gussmann, A, Strasburger, JF, Srinivasan, S, et al. Fetal atrial flutter: electrophysiology and associations with rhythms involving an accessory pathway. J Am Heart Assoc. 2016; 5: e003673.Google Scholar
Eswaran, H, Escalona-Vargas, D, Bolin, EH, et al. Fetal magnetocardiography using optically pumped magnetometers: a more adaptable and less expensive alternative? Prenat Diagn. 2017; 37: 193–6.Google Scholar
Rasiah, SV, Ewer, AK, Miller, P, et al. Prenatal diagnosis, management and outcome of fetal dysrhythmia: a tertiary fetal medicine centre experience over an eight-year period. Fetal DiagnTher. 2011; 30: 122–7.Google Scholar
Fouron, JC. Fetal arrhythmias: the Saint-Justine hospital experience. Prenat Diagn. 2004; 24: 1068–80.CrossRefGoogle ScholarPubMed
Cuneo, BF, Strasburger, JF, Wakai, RT, et al. Conduction system disease in fetuses evaluated for irregular cardiac rhythm. Fetal Diagn Ther. 2006; 21: 307–13.Google Scholar
Srinivasan, S, Strasburger, J. Overview of fetal arrhythmias. Curr Opin Pediatr. 2008; 20: 522–31.Google Scholar
Eliasson, H, Wahren-Herlenius, M, Sonesson, SE. Mechanisms in fetal bradyarrhythmia: 65 cases in a single center analyzed by Doppler flow echocardiographic techniques. Ultrasound Obstet Gynecol. 2011; 37:172–8.Google Scholar
Wiggins, DL, Strasburger, JF, Gotteiner, NL, et al. Magnetophysiologic and echocardiographic comparison of blocked atrial bigeminy and 2:1 atrioventricular block in the fetus. Heart Rhythm. 2013; 10: 1192–8.Google Scholar
Carvalho, JS. Primary bradycardia: keys and pitfalls in diagnosis. Ultrasound Obstet Gynecol. 2014; 44: 125–30.Google Scholar
Strasburger, JF, Wakai, RT. Fetal cardiac arrhythmia detection and in utero therapy. Nat Rev Cardiol. 2010; 7: 277–90.Google Scholar
Jaeggi, ET, Carvalho, JS, De Groot, E, et al. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation. 2011; 124: 1747–54.Google Scholar
Uzun, O, Babaoglu, K, Sinha, A, et al. Rapid control of foetal supraventricular tachycardia with digoxin and flecainide combination treatment. Cardiol Young. 2012; 22: 372–80.Google Scholar
Gembruch, U. Fetal Tachyarrhythmia. In Yagel, S, Silverman, NH, Gembruch, U, eds., Fetal Cardiology: Maternal-Fetal Medicine. New York: Informa Healthcare, 2009, pp. 461–81.Google Scholar
Oudijk, MA, Stoutenbeek, P, Sreeram, N, et al. Persistent junctional reciprocating tachycardia in the fetus. J Matern Fetal Neonatal Med. 2003; 13: 191–6.Google Scholar
Zaidi, SJ, Siddiqui, S, Cuneo, BF, et al. Prenatal diagnosis and management of junctional ectopic tachycardia. Heart Rhythm Case Rep. 2017; 3: 503–8.Google Scholar
Dubin, AM, Cuneo, BF, Strasburger, JF, et al. Congenital junctional ectopic tachycardia and congenital complete atrioventricular block: a shared etiology? Heart Rhythm. 2005; 2: 313–15.Google Scholar
Kang, SL, Howe, D, Coleman, M, et al. Foetal supraventricular tachycardia with hydrops fetalis: a role for direct intraperitoneal amiodarone. Cardiol Young. 2015; 25: 447–53.Google Scholar
Shah, A, Moon-Grady, A, Bhogal, N, et al. Effectiveness of sotalol as first-line therapy for fetal supraventricular tachyarrhythmias. Am J Cardiol. 2012; 109: 1614–18.Google Scholar
Sridharan, S, Sullivan, I, Tomek, V, et al. Flecainide versus digoxin for fetal supraventricular tachycardia: comparison of two drug treatment protocols. Heart Rhythm. 2016; 13: 1913–19.Google Scholar
Ekman-Joelsson, BM, Mellander, M, Lagnefeldt, L, et al. Foetal tachyarrhythmia treatment remains challenging even if the vast majority of cases have a favourable outcome. Acta Paediatr. 2015; 104: 1090–7.Google Scholar
Strizek, B, Berg, C, Gottschalk, I, et al. High-dose flecainide is the most effective treatment of fetal supraventricular tachycardia. Heart Rhythm. 2016; 13: 1283–8.Google Scholar
Ekiz, A, Kaya, B, Bornaun, H, et al. Flecainide as first-line treatment for fetal supraventricular tachycardia. J Matern Fetal Neonatal Med. 2018; 31: 407–12.Google Scholar
Hill, GD, Kovach, JR, Saudek, DE, et al. Transplacental treatment of fetal tachycardia: a systematic review and meta-analysis. Prenat Diagn. 2017; 37: 1076–83.Google Scholar
Strasburger, JF, Cuneo, BF, Michon, MM, et al. Amiodarone therapy for drug-refractory fetal tachycardia. Circulation. 2004; 109: 375–9.Google Scholar
Jouannic, JM, Delahaye, S, Fermont, L, et al. Fetal supraventricular tachycardia: a role for amiodarone as second-line therapy? Prenat Diagn. 2003; 23: 152–6.Google Scholar
Parilla, BV, Strasburger, JF, Socol, ML. Fetal supraventricular tachycardia complicated by hydrops fetalis: a role for direct fetal intramuscular therapy. Am J Perinatol. 1996; 13: 483–6.CrossRefGoogle ScholarPubMed
Vigneswaran, TV, Callaghan, N, Andrews, RE, et al. Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia. Heart Rhythm. 2014; 11: 2047–53.Google Scholar
Cuneo, BF, Strasburger, JF. We only find what we look for: fetal heart rate and the diagnosis of long-QT syndrome. Circ Arrhythm Electrophysiol. 2015; 8: 760–2.Google Scholar
Lopes, LM, Tavares, GM, Damiano, AP, et al. Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution. Circulation. 2008; 118: 1268–75.Google Scholar
Glatz, AC, Gaynor, JW, Rhodes, LA, et al. Outcome of high-risk neonates with congenital complete heart block paced in the first 24 hours after birth. J Thorac Cardiovasc Surg. 2008; 136: 767–73.Google Scholar
Baruteau, AE, Fouchard, S, Behaghel, A, et al. Characteristics and long-term outcome of non-immune isolated atrioventricular block diagnosed in utero or early childhood: a multicentre study. Eur Heart J. 2012; 33: 622–9.CrossRefGoogle ScholarPubMed
Eliasson, H, Sonesson, SE, Sharland, G, et al. Isolated atrioventricular block in the fetus: a retrospective multinational, multicentre study of 175 patients. Circulation. 2011; 124: 1919–26.Google Scholar
Van Hare, GF. Magnetocardiography in the diagnosis of fetal arrhythmias. Heart Rhythm. 2013; 10: 1199–200.Google Scholar
Buyon, JP, Hiebert, R, Copel, J, et al. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol. 1998; 31: 1658–66.Google Scholar
Levesque, K, Morel, N, Maltret, A, et al. Description of 214 cases of autoimmune congenital heart block: results of the French neonatal lupus syndrome. Autoimmun Rev. 2015; 14: 1154–60.Google Scholar
Friedman, DM, Kim, MY, Copel, JA, et al. Utility of Cardiac Monitoring in Fetuses at Risk for Congenital Heart Block: The PR Interval and Dexamethasone Evaluation (PRIDE) Prospective Study. Circulation. 2008; 117: 485–93.Google Scholar
Jaeggi, E, Laskin, C, Hamilton, R, et al. The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol. 2010; 55: 2778–84.Google Scholar
Hutter, D, Silverman, ED, Jaeggi, ET. The benefits of transplacental treatment of isolated congenital complete heart block associated with maternal anti-Ro/SSA antibodies: a review. Scand J Immunol. 2010; 72: 235–41.Google Scholar
Saxena, A, Izmirly, PM, Mendez, B, et al. Prevention and treatment in utero of autoimmune-associated congenital heart block. Cardiol Rev. 2014; 22: 263–7.Google Scholar
Vest, AN, Zhou, L, Huang, X, et al. Design and testing of a transcutaneous RF recharging system for a fetal micropacemaker. IEEE Trans Biomed Circuits Syst. 2017; 11: 336–46.CrossRefGoogle ScholarPubMed
Cuneo, BF, Mitchell, MB, Marwan, AI, et al. Ex utero intrapartum treatment to ventricular pacing: a novel delivery strategy for complete atrioventricular block with severe bradycardia. Fetal Diagn Ther. 2017; 42: 311–14.Google Scholar
Izmirly, PM, Costedoat-Chalumeau, N, Pisoni, C, et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/RO associated cardiac manifestations of neonatal lupus. Circulation. 2012; 126: 7682.Google Scholar
Ciardulli, A, D’Antonio, F, Magro-Malosso, ER, et al. Maternal steroid therapy for fetuses with second-degree immune-mediated congenital atrioventricular block: a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2018; 97: 787–94.Google Scholar
Van den Berg, NW, Slieker, MG, van Beynum, IM, et al. Fluorinated steroids do not improve outcome of isolated atrioventricular block. Int J Cardiol. 2016; 225: 167–71.Google Scholar
Izmirly, PM, Saxena, A, Sahl, SK, et al. Assessment of fluorinated steroids to avert progression and mortality in anti-SSA/Ro-associated cardiac injury limited to the fetal conduction system. Ann Rheum Dis. 2016; 75: 1161–5.Google Scholar
Cuneo, BF, Ambrose, SE, Tworetzky, W. Detection and successful treatment of emergent anti-SSA-mediated fetal atrioventricular block. Am J Obstet Gynecol. 2016; 215: 27–8.Google Scholar
Cuneo, BF, Zhao, H, Strasburger, JF, et al. Atrial and ventricular rate response and patterns of heart rate acceleration during maternal-fetal terbutaline treatment of fetal complete heart block. Am J Cardiol. 2007; 100: 661–5.Google Scholar
Friedman, DM, Llanos, C, Izmirly, PM, et al. Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: results of a multicenter, prospective, open-label clinical trial. Arthritis Rheum. 2010; 62: 1138–46.CrossRefGoogle Scholar
Pisoni, CN, Brucato, A, Ruffatti, A, et al. Failure of intravenous immunoglobulin to prevent congenital heart block: findings of a multicenter, prospective, observational study. Arthritis Rheum. 2010; 62: 1147–52.Google Scholar
Trucco, SM, Jaeggi, E, Cuneo, B, et al. Use of intravenous gamma globulin and corticosteroids in the treatment of maternal autoantibody-mediated cardiomyopathy. J Am Coll Cardiol. 2011; 57: 715–23.Google Scholar
Ruffatti, A, Cerutti, A, Favaro, M, et al. Plasmapheresis, intravenous immunoglobulins and bethametasone – a combined protocol to treat autoimmune congenital heart block: a prospective cohort study. Clin Exp Rheumatol. 2016; 34: 706–13.Google ScholarPubMed
Rein, AJ, Mevorach, D, Perles, Z, et al. Early diagnosis and treatment of atrioventricular block in the fetus exposed to maternal anti-SSA/ RO-SSB/LA antibodies. a prospective, observational, fetal kinetocardiogram-based study. Circulation. 2009; 119: 1867–72.Google Scholar
Jaeggi, ET, Silverman, ED, Laskin, C, et al. Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. A prospective observational study on the effects of maternal antibodies on 165 fetuses. J Am Coll Cardiol. 2011; 57: 1487–92.Google Scholar
Bergman, G, Eliasson, H, Bremme, K, et al. Anti-Ro52/SSA antibody-exposed fetuses with prolonged atrioventricular time intervals show signs of decreased cardiac performance. Ultrasound Obstet Gynecol. 2009; 34: 543–9.Google Scholar
Kan, N, Silverman, ED, Kingdom, J, et al. Serial echocardiography for immune-mediated heart disease in the fetus: results of a risk-based prospective surveillance strategy. Prenat Diagn. 2017; 37: 375–82.Google Scholar
Cuneo, BF, Moon-Grady, AJ, Sonesson, SE, et al. Heart sounds at home: feasibility of an ambulatory fetal heart rhythm surveillance program for anti-SSA-positive pregnancies. J Perinatol. 2017; 37: 226–30.Google Scholar

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