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Chapter 20 - Rhabdomyomas and rhabdomyosarcomas

Published online by Cambridge University Press:  19 October 2016

Markku Miettinen
Affiliation:
National Cancer Institute, Maryland
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Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
, pp. 527 - 552
Publisher: Cambridge University Press
Print publication year: 2016

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References

Rubin, BP, Nishijo, K, Chen, HI, et al. Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell 2011;19:177191.CrossRefGoogle ScholarPubMed
Shern, JF, Chen, L, Chmielecki, J, et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov 2014;4:216231.Google Scholar
Enzinger, FM, Weiss, SW. Rhabdomyoma and rhabdomyosarcoma. In Soft Tissue Tumors, 4th edn. St. Louis: Mosby; 2001: 771.Google Scholar
Pendle, F. Uber ein congenitales Rhabdomyom der Zunge. Ztschn Neilkund 1897;18:457468.Google Scholar
Dehner, LP, Enzinger, FM, Font, RL. Fetal rhabdomyoma: an analysis of nine cases. Cancer 1972;30:160166.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Kapadia, SB, Meis, JM, Frisman, DM, Ellis, GL, Heffner, DK. Fetal rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study of 24 cases. Hum Pathol 1993;24:754765.Google Scholar
O'Shea, P. Pediatric Soft Tissue Tumors: A Clinical, Pathologic, and Therapeutic Approach. Baltimore: Williams & Wilkins; 1997: 214.Google Scholar
Kodet, R, Fajstavr, J, Kabelka, Z, et al. Is fetal cellular rhabdomyoma an entity or a differentiated rhabdomyosarcoma?: a study of patients with rhabdomyoma of the tongue and sarcoma of the tongue enrolled in the intergroup rhabdomyosarcoma studies I, II, and III. Cancer 1991;67:29072913.3.0.CO;2-B>CrossRefGoogle ScholarPubMed
Crotty, PL, Nakhleh, RE, Dehner, LP. Juvenile rhabdomyoma: an intermediate form of skeletal muscle tumor in children. Arch Pathol Lab Med 1993;117:4347.Google ScholarPubMed
Tostar, U, Malm, CJ, Meis-Kindblom, JM, et al. Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 2006;208:1725.Google Scholar
Hettmer, S, Teot, LA, van Hummelen, P, et al. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol 2013;231:4452.Google Scholar
Agamanolis, DP, Dasu, S, Krill, CE Jr. Tumors of skeletal muscle. Hum Pathol 1986;17:778795.Google Scholar
Kapadia, SB, Meis, JM, Frisman, DM, et al. Adult rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study. Hum Pathol 1993;24:608617.Google Scholar
Solomon, MP, Tolete-Velcek, F. Lingual rhabdomyoma (adult variant) in a child. J Pediatr Surg 1979;14:9194.Google Scholar
Hansen, T, Katenkamp, D. Rhabdomyoma of the head and neck: morphology and differential diagnosis. Virchows Arch 2005;447:849854.CrossRefGoogle ScholarPubMed
Friedman, MT, Molho, L, Valderrama, E, Kahn, LB. Crystal-storing histiocytosis associated with a lymphoplasmacytic neoplasm mimicking adult rhabdomyoma: a case report and review of the literature. Arch Pathol Lab Med 1996;120:11331136.Google Scholar
Gibas, Z, Miettinen, M. Recurrent parapharyngeal rhabdomyoma: evidence of neoplastic nature of the tumor from cytogenetic study. Am J Surg Pathol 1992;16:721728.CrossRefGoogle ScholarPubMed
Willis, J, Abdul-Karim, FW, di Sant'Agnese, PA. Extracardiac rhabdomyomas. Semin Diagn Pathol 1994;11:1525.Google ScholarPubMed
Konrad, EA, Meister, P, Hubner, G. Extracardiac rhabdomyoma: report of different types with light microscopic and ultrastructural studies. Cancer 1982;49:898907.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Tanda, F, Rocca, PC, Bosincu, L, et al. Rhabdomyoma of the tunica vaginalis of the testis: a histologic, immunohistochemical, and ultrastructural study. Mod Pathol 1997;10:608611.Google Scholar
Hanski, W, Hagel-Lewicka, E, Daniszewski, K. Rhabdomyomas of female genital tract: report on two cases. Zentralbl Pathol 1991;137:439442.Google ScholarPubMed
Ostor, AG, Fortune, DW, Riley, CB. Fibroepithelial polyps with atypical stromal cells (pseudosarcoma botryoides) of vulva and vagina: a report of 13 cases. Int J Gynecol Pathol 1988;7:351360.Google Scholar
Kawamoto, S, Matsuda, H, Ueki, K, Okada, Y, Kim, P. Neuromuscular choristoma of the oculomotor nerve: case report. Neurosurgery 2007;60:E777E778; discussion E778.CrossRefGoogle ScholarPubMed
Tobias, S, Kim, CH, Sade, B, Staugaitis, SM, Lee, JH. Neuromuscular hamartoma of the trigeminal nerve in an adult. Acta Neurochir 2006;148:8387; discussion 87.Google Scholar
Uysal, A, Sungur, N, Kocer, U, et al. Neuromuscular hamartoma of the occipital nerve: clinical report. J Craniofacial Surg 2005;16:740742.CrossRefGoogle ScholarPubMed
Tiffee, JC, Barnes, EL. Neuromuscular hamartomas of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124:212216.Google Scholar
Van Dorpe, J, Sciot, R, De Vos, R, et al. Neuromuscular choristoma (hamartoma) with smooth and striated muscle component: case report with immunohistochemical and ultrastructural analysis. Am J Surg Pathol 1997;21:10901095.CrossRefGoogle ScholarPubMed
Mavrikakis, I, White, VA, Heran, M, Rootman, J. Orbital mesenchymal hamartoma with rhabdomyomatous features. Br J Ophthalmol 2007;91:692693.Google Scholar
De la Sotta, P, Salomone, C, Gonzalez, S. Rhabdomyomatous (mesenchymal) hamartoma of the tongue: report of a case. J Oral Pathol Med 2007;36:5859.CrossRefGoogle ScholarPubMed
Ortak, T, Orbay, H, Unlu, E, et al. Rhabdomyomatous mesenchymal hamartoma. J Craniofacial Surg 2005;16:11351137.CrossRefGoogle ScholarPubMed
Magro, G, Di Benedetto, A, Sanges, G, Scalisi, F, Alaggio, R. Rhabdomyomatous mesenchymal hamartoma of oral cavity: an unusual location for such a rare lesion. Virchows Arch 2005;446:346347.CrossRefGoogle ScholarPubMed
Rosenberg, AS, Kirk, J, Morgan, MB. Rhabdomyomatous mesenchymal hamartoma: an unusual dermal entity with a report of two cases and a review of the literature. J Cutan Pathol 2002;29:238243.CrossRefGoogle Scholar
Read, RW, Burnstine, M, Rowland, JM, Zamir, E, Rao, NA. Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review. Ophthalmology 2001;108:798804.CrossRefGoogle ScholarPubMed
Takeyama, J, Hayashi, T, Sanada, T, et al. Rhabdomyomatous mesenchymal hamartoma associated with nasofrontal meningocele and dermoid cyst. J Cutan Pathol 2005;32:310313.Google Scholar
Adam, MP, Abramowsky, CR, Brady, AN, Coleman, K, Todd, NW. Rhabdomyomatous hamartomata of the pharyngeal region with bilateral microtia and aural atresia: a new association? Birth defects research Part A. Clin Mol Teratol 2007;79:242248.Google Scholar
Heffner, RR Jr., Armbrustmacher, VW, Earle, KM. Focal myositis. Cancer 1977;40:301306.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Colding-Jorgensen, E, Laursen, H, Lauritzen, M. Focal myositis of the thigh: report of two cases. Acta Neurol Scand 1993;88:289292.Google Scholar
Ellis, GL, Brannon, RB. Focal myositis of the perioral musculature. Oral Surg Oral Med Oral Pathol 1979;48:337341.Google Scholar
Heffner, RR Jr., Barron, SA. Denervating changes in focal myositis, a benign inflammatory pseudotumor. Arch Pathol Lab Med 1980;104:261264.Google Scholar
Flaisler, F, Blin, D, Asencio, G, Lopez, FM, Combe, B. Focal myositis: a localized form of polymyositis? J Rheumatol 1993;20:14141416.Google ScholarPubMed
Weber, C. Anatomishche Untersuchung einer hypertrophische Zunge nebst Bemerkunger uber die Neubildung quergestreifter Muskelfasern. Virchows Arch 1854;7:115.Google Scholar
Berard, M. Tumeur embryonnaire du muscle striae. Lyon Med 1894:52.Google Scholar
Riopelle, JL, Theriault, JP. [An unknown type of soft part sarcoma: alveolar rhabdomyosarcoma]. Ann Anat Pathol (Paris) 1956;1:88111.Google Scholar
Horn, RC Jr., Enterline, HT. Rhabdomyosarcoma: a clinicopathological study and classification of 39 cases. Cancer 1958;11:181199.Google Scholar
Newton, WA Jr., Gehan, EA, Webber, BL, et al. Classification of rhabdomyosarcomas and related sarcomas: pathologic aspects and proposal for a new classification – an Intergroup Rhabdomyosarcoma Study. Cancer 1995;76:10731085.Google Scholar
Qualman, SJ, Coffin, CM, Newton, WA, et al. Intergroup Rhabdomyosarcoma Study: update for pathologists. Pediatr Dev Pathol 1998;1:550561.CrossRefGoogle ScholarPubMed
Skapek, SX, Anderson, J, Barr, FG, et al. PAX-FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: a children's oncology group report. Pediatr Blood Cancer 2013;60:14111417.Google Scholar
Fletcher, CDM, Bridge, JA, Hogendoorn, PCW, Mertens, F. WHO Classification of Tumours of Soft Tissue and Bone. Lyon: International Agency for Research of Cancer; 2013.Google Scholar
Locatelli, F, Tonani, P, Porta, F, et al. Rhabdomyosarcoma with primary osteolytic lesions simulating non-Hodgkin's lymphoma. Pediatr Hematol Oncol 1991;8:159164.Google Scholar
Arndt, CA, Crist, WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 1999;341:342352.Google Scholar
Coffin, CM, Rulon, J, Smith, L, Bruggers, C, White, FV. Pathologic features of rhabdomyosarcoma before and after treatment: a clinicopathologic and immunohistochemical analysis. Mod Pathol 1997;10:11751187.Google Scholar
Arndt, CA, Hammond, S, Rodeberg, D, Qualman, S. Significance of persistent mature rhabdomyoblasts in bladder/prostate rhabdomyosarcoma: results from IRS IV. J Pediatr Hematol Oncol 2006;28:563567.Google Scholar
Meza, JL, Anderson, J, Pappo, AS, Meyer, WH. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the Children's Oncology Group. J Clin Oncol 2006;24:38443851.Google Scholar
Parham, DM, Barr, FG. Classification of rhabdomyosarcoma and its molecular basis. Adv Anat Pathol 2013;20:387397.Google Scholar
Scott, RS, Jagirdar, J. Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. Ann Diagn Pathol 2007;11:274276.Google Scholar
Smith, LM, Anderson, JR, Qualman, SJ, et al. Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy?: a report from the soft tissue sarcoma committee of the children's oncology group. J Clin Oncol 2001;19:40584064.CrossRefGoogle ScholarPubMed
Rudzinski, ER, Teot, LA, Anderson, JR, et al. Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Am J Clin Pathol 2013;140:8290.Google Scholar
Bridge, JA, Liu, J, Weibolt, V, et al. Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study. Genes Chromosomes Cancer 2000;27:337344.Google Scholar
Merlino, G, Helman, LJ. Rhabdomyosarcoma: working out the pathways. Oncogene 1999;18:53405348.Google Scholar
Bridge, JA, Liu, J, Qualman, SJ, et al. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer 2002;33:310321.Google Scholar
Leuschner, I, Newton, WA Jr., Schmidt, D, et al. Spindle cell variants of embryonal rhabdomyosarcoma in the paratesticular region. A report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Pathol 1993;17:221230.Google Scholar
Mentzel, T, Katenkamp, D. Sclerosing, pseudovascular rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of three cases. Virchows Arch 2000;436:305311.Google Scholar
Folpe, AL, McKenney, JK, Bridge, JA, Weiss, SW. Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma. Am J Surg Pathol 2002;26:11751183.Google Scholar
Chiles, MC, Parham, DM, Qualman, SJ, et al. Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group. Pediatr Dev Pathol 2004;7:583594.CrossRefGoogle Scholar
Kikuchi, K, Wettach, GR, Ryan, CW, et al. MDM2 amplification and PI3KCA mutation in a case of sclerosing rhabdomyosarcoma. Sarcoma 2013;2013:520858.Google Scholar
Mosquera, JM, Sboner, A, Zhang, L, et al. Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. Genes Chromosomes Cancer 2013;52:538550.CrossRefGoogle ScholarPubMed
Parham, DM, Ellison, DA. Rhabdomyosarcomas in adults and children: an update. Arch Pathol Lab Med 2006;130:14541465.Google Scholar
Kuhnen, C, Herter, P, Leuschner, I, et al. Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma. Virchows Arch 2006;449:572578.Google Scholar
Croes, R, Debiec-Rychter, M, Cokelaere, K, et al. Adult sclerosing rhabdomyosarcoma: cytogenetic link with embryonal rhabdomyosarcoma. Virchows Arch 2005;446:6467.Google Scholar
Morandi, S, Manna, A, Sabattini, E, Porcellini, A. Rhabdomyosarcoma presenting as acute leukemia. J Pediatr Hematol Oncol 1996; 18:305307.CrossRefGoogle ScholarPubMed
Tsokos, M, Webber, BL, Parham, DM, et al. Rhabdomyosarcoma: a new classification scheme related to prognosis. Arch Pathol Lab Med 1992;116:847855.Google ScholarPubMed
Kazanowska, B, Jelen, M, Reich, A, Tarnawski, W, Chybicka, A. The role of nuclear morphometry in prediction of prognosis for rhabdomyosarcoma in children. Histopathology 2004;45:352359.Google Scholar
Parham, DM, Shapiro, DN, Downing, JR, Webber, BL, Douglass, EC. Solid alveolar rhabdomyosarcomas with the t(2;13): report of two cases with diagnostic implications. Am J Surg Pathol 1994;18:474478.Google Scholar
Scrable, H, Witte, D, Shimada, H, et al. Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes Cancer 1989;1:2335.Google Scholar
Kelly, KM, Womer, RB, Sorensen, PH, Xiong, QB, Barr, FG. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol 1997;15:18311836.Google Scholar
Barr, FG, Qualman, SJ, Macris, MH, et al. Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. Cancer Res 2002;62:47044710.Google Scholar
Davicioni, E, Finckenstein, FG, Shahbazian, V, et al. Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas. Cancer Res 2006;66:69366946.CrossRefGoogle ScholarPubMed
Missiaglia, E, Williamson, D, Chisholm, J, et al. PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification. J Clin Oncol 2012;30:16701677.CrossRefGoogle ScholarPubMed
Furlong, MA, Fanburg-Smith, JC. Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol 2001;5:199206.Google Scholar
Gaffney, EF, Dervan, PA, Fletcher, CD. Pleomorphic rhabdomyosarcoma in adulthood: analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol 1993;17:601609.Google Scholar
Wesche, WA, Fletcher, CD, Dias, P, Houghton, PJ, Parham, DM. Immunohistochemistry of MyoD1 in adult pleomorphic soft tissue sarcomas. Am J Surg Pathol 1995;19:261269.Google Scholar
Gordon, A, McManus, A, Anderson, J, et al. Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case. Cancer Genet Cytogenet 2003;140:7377.Google Scholar
Kodet, R, Newton, WA Jr., Hamoudi, AB, et al. Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features: a report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Pathol 1993;17:443453.Google Scholar
Govender, D, Chetty, R. Clear cell (glycogen-rich) rhabdomyosarcoma presenting as cervical lymphadenopathy. ORL 1999;61:5254.Google Scholar
Boman, F, Champigneulle, J, Schmitt, C, et al. Clear cell rhabdomyosarcoma. Pediatr Pathol Lab Med 1996;16:951959.Google Scholar
Chan, JK, Ng, HK, Wan, KY, et al. Clear cell rhabdomyosarcoma of the nasal cavity and paranasal sinuses. Histopathology 1989;14:391399.Google Scholar
Quincey, C, Banerjee, SS, Eyden, BP, Vasudev, KS. Lipid rich rhabdomyosarcoma. J Clin Pathol 1994;47:280282.Google Scholar
Zuppan, CW, Mierau, GW, Weeks, DA. Lipid-rich rhabdomyosarcoma: a potential source of diagnostic confusion. Ultrastruct Pathol 1991;15:353359.Google Scholar
Kodet, R, Newton, WA Jr., Hamoudi, AB, Asmar, L. Rhabdomyosarcomas with intermediate-filament inclusions and features of rhabdoid tumors: light microscopic and immunohistochemical study. Am J Surg Pathol 1991;15:257267.Google Scholar
Caputo, V, Repetti, ML, Grimoldi, N, et al. Cerebral rhabdomyosarcoma with rhabdoid tumor-like features. J Neuro oncol 1997;32:8186.Google Scholar
Jo, VY, Marino-Enriquez, ML, Fletcher, CD. Epithelioid rhabdomyosarcoma: clinicopathologic analysis of 16 cases of a morphologically distinct variant of rhabdomyosarcoma. AM J Surg Pathol 2011;35:15231530.Google Scholar
Zin, A, Bertorelle, R, Dall’Igna, P, et al. Epithelioid rhabdomyosarcoma: a clinicopathologic and molecular study. AM J Surg Pathol 2014;38:273278.CrossRefGoogle ScholarPubMed
Hoot, AC, Russo, P, Judkins, AR, Perlman, EJ, Biegel, JA. Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors. Am J Surg Pathol 2004;28:14851491.Google Scholar
Uno, K, Takita, J, Yokomori, K, et al. Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors. Genes Chromosomes Cancer 2002;34:3341.Google Scholar
Newsham, I, Daub, D, Besnard-Guerin, C, Cavenee, W. Molecular sublocalization and characterization of the 11;22 translocation breakpoint in a malignant rhabdoid tumor. Genomics 1994;19:433440.Google Scholar
Karnes, PS, Tran, TN, Cui, MY, et al. Establishment of a rhabdoid tumor cell line with a specific chromosomal abnormality, 46,XY,t(11;22)(p15.5;q11.23). Cancer Genet Cytogenet 1991;56:3138.Google Scholar
Sabbioni, S, Veronese, A, Trubia, M, et al. Exon structure and promoter identification of STIM1 (alias GOK), a human gene causing growth arrest of the human tumor cell lines G401 and RD. Cytogenet Cell Genet 1999;86:214218.Google Scholar
DeCristofaro, MF, Betz, BL, Wang, W, Weissman, BE. Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors. Oncogene 1999;18:75597565.Google Scholar
Kumar, S, Perlman, E, Harris, CA, Raffeld, M, Tsokos, M. Myogenin is a specific marker for rhabdomyosarcoma: an immunohistochemical study in paraffin-embedded tissues. Mod Pathol 2000;13:988993.Google Scholar
Mouton, SC, Rosenberg, HS, Cohen, MC, et al. Malignant ectomesenchymoma in childhood. Pediatr Pathol Lab Med 1996;16:607624.CrossRefGoogle ScholarPubMed
Bahrami, A, Gown, AM, Baird, GS, Hicks, MJ, Folpe, AL. Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. Mod Pathol 2008;21:795806.Google Scholar
Edwards, V, Tse, G, Doucet, J, Pearl, R, Phillips, MJ. Rhabdomyosarcoma metastasizing as a malignant ectomesenchymoma. Ultrastruct Pathol 1999;23:267273.Google Scholar
Brooks, J. Immunohistochemistry in the differential diagnosis of soft tissue tumors. In Soft Tissue Tumors, Weiss, SW, Brooks, JSJ (eds.) No 38 in the USCAP Monographs in Pathology series, Baltimore: Williams & Wilkins; 1996: 65.Google Scholar
Azumi, N, Ben-Ezra, J, Battifora, H. Immunophenotypic diagnosis of leiomyosarcomas and rhabdomyosarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue. Mod Pathol 1988;1:469474.Google Scholar
Parham, DM, Reynolds, AB, Webber, BL. Use of monoclonal antibody 1H1, anticortactin, to distinguish normal and neoplastic smooth muscle cells: comparison with anti-alpha-smooth muscle actin and antimuscle-specific actin. Hum Pathol 1995;26:776783.CrossRefGoogle ScholarPubMed
Parham, DM, Dias, P, Kelly, DR, Rutledge, JC, Houghton, P. Desmin positivity in primitive neuroectodermal tumors of childhood. Am J Surg Pathol 1992;16:483492.Google Scholar
Somerhausen, NS, Fletcher, CD. Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol 2000;24:479492.Google Scholar
Leader, M, Patel, J, Collins, M, Henry, K. Myoglobin: an evaluation of its role as a marker of rhabdomyosarcomas. Br J Cancer 1989;59:106109.Google Scholar
Eusebi, V, Bondi, A, Rosai, J. Immunohistochemical localization of myoglobin in nonmuscular cells. Am J Surg Pathol 1984;8:5155.Google Scholar
Dias, P, Dilling, M, Houghton, P. The molecular basis of skeletal muscle differentiation. Semin Diagn Pathol 1994;11:314.Google Scholar
Wang, NP, Marx, J, McNutt, MA, Rutledge, JC, Gown, AM. Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol 1995;147:17991810.Google Scholar
Mukunyadzi, P. DPHPea: comparison of MyoD1 immunostaining of pediatric tumors using frozen or paraffin-embedded sections. Appl Immunohistochem Mol Morphol 1999;7:260.CrossRefGoogle Scholar
Mentzel, T, Kuhnen, C. Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch 2006;449:554560.Google Scholar
Ellison, DA, Adada, B, Qualman, SJ, Parham, DM. Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation. Pediatr Dev Pathol 2007;10:157160.Google Scholar
Dias, P, Chen, B, Dilday, B, et al. Strong immunostaining for myogenin in rhabdomyosarcoma is significantly associated with tumors of the alveolar subclass. Am J Pathol 2000;156:399408.Google Scholar
Morotti, RA, Nicol, KK, Parham, DM, et al. An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. Am J Surg Pathol 2006;30:962968.Google Scholar
Chen, B, Dias, P, Jenkins, JJ 3rd, Savell, VH, Parham, DM. Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas. Am J Pathol 1998;152:10711079.Google Scholar
Rudzinski, ER, Anderson, JR, Lyden, ER, et al. Myogenin, AP2beta, NOS-1, and HMGA2 are surrogate markers of fusion status in rhabdomyosarcoma: a report from the soft tissue sarcoma committee of the children's oncology group. Am J Surg Pathol 2014;38:654659.Google Scholar
Furlong, MA, Mentzel, T, Fanburg-Smith, JC. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol 2001;14:595603.Google Scholar
Walterhouse, D, Watson, A. Optimal management strategies for rhabdomyosarcoma in children. Paediatr Drugs 2007;9:391400.Google Scholar
d'Amore, ES, Tollot, M, Stracca-Pansa, V, et al. Therapy associated differentiation in rhabdomyosarcomas. Mod Pathol 1994;7:6975.Google Scholar
Smith, LM, Anderson, JR, Coffin, CM. Cytodifferentiation and clinical outcome after chemotherapy and radiation therapy for rhabdomyosarcoma (RMS). Med Pediatr Oncol 2002;38:398404.Google Scholar
Gu, W, Schneider, JW, Condorelli, G, et al. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 1993;72:309324.Google Scholar
Diller, L, Sexsmith, E, Gottlieb, A, Li, FP, Malkin, D. Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest 1995;95:16061611.Google Scholar
Hettmer, S, Archer, NM, Somers, GR, et al. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Cancer 2014;120:10681075.Google Scholar
Zhang, L, Zhan, Q, Zhan, S, et al. p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells. DNA Cell Biol 1998;17:125131.CrossRefGoogle ScholarPubMed
Kilpatrick, SE, Teot, LA, Geisinger, KR, et al. Relationship of DNA ploidy to histology and prognosis in rhabdomyosarcoma: comparison of flow cytometry and image analysis. Cancer 1994;74:32273233.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
De Zen, L, Sommaggio, A, d'Amore, ES, et al. Clinical relevance of DNA ploidy and proliferative activity in childhood rhabdomyosarcoma: a retrospective analysis of patients enrolled onto the Italian Cooperative Rhabdomyosarcoma Study RMS88. J Clin Oncol 1997;15:11981205.Google Scholar

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