Hostname: page-component-848d4c4894-sjtt6 Total loading time: 0 Render date: 2024-06-19T09:55:49.408Z Has data issue: false hasContentIssue false
  • English
  • Français

Regional Cerebral Blood Flow in Patients with Affective Disorders

Published online by Cambridge University Press:  02 January 2018

V. Delvenne ,
F. Delecluse ,
Ph. P. Hubain ,
A. Schoutens ,
V. De Maertelaer  and
J. Mendlewicz
V. Delvenne
Affiliation:
Department of Psychiatry, Erasme Hospital
F. Delecluse
Affiliation:
Department of Nuclear Medicine, Erasme Hospital
Ph. P. Hubain
Affiliation:
Department of Psychiatry, Erasme Hospital
A. Schoutens
Affiliation:
Department of Nuclear Medicine, Erasme Hospital
V. De Maertelaer
Affiliation:
IRIBHN Statistical Unit, Free University of Brussels, Brussels, Belgium
J. Mendlewicz*
Affiliation:
Department of Psychiatry, Erasme Hospital, University Clinics of Brussels, Free University of Brussels, 808 route de Lennik, 1070 Brussels, Belgium
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Extract

Regional cerebral blood flow at rest was measured in 38 patients with major depressive disorders and 16 controls by SPECT with inhalation of xenon-133. All subjects had been withdrawn from medication. The mean hemispheric cerebral blood flow was not statistically different between the controls and the different subgroups of depressed patients defined either by biological markers or clinical characteristics. However, the predominantly cortical blood flow, measured on the outer cerebral rim of the third tomographic slice, was significantly lower on the left hemisphere in bipolar patients when compared with normals and unipolar patients. The same lateralisation was observed in patients with an endogenous depression according to the Newcastle scale.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 3 , September 1990 , pp. 359 - 365
Copyright
Copyright © Royal College of Psychiatrists, 1990 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alexander, S. C., Wollman, H., Cohen, P. J., et al (1964) Cerebrovascular response to PaCO2 during halothane anesthesia in man. Journal of Applied Physiology, 19, 561–565.Google Scholar
Berman, D. S., Garcia, E. V. & Maddahi, J. (1981) Thallium-201 myocardial scintigraphy in the detection and evaluation of coronary artery disease. In Clinical Nuclear Cardiology (eds D. S. Berman & D. T. Mason) pp. 49–106. London: Academic Press.Google Scholar
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–674.CrossRefGoogle Scholar
Caroll, B. J., Curtis, G. C. & Mendels, J. (1976) Neuroendocrine regulation in depression. II: Discrimination of depressed from non-depressed patients. Archives of General Psychiatry, 33, 1051–1058.CrossRefGoogle Scholar
Celsis, P., Goldman, T., Henriksen, L., et al (1981) A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentration. Journal of Computer Assisted Tomography, 5, 641–645.CrossRefGoogle Scholar
D'Elia, G. & Perris, C. (1973) Cerebral functional dominance and depression. Acta Psychiatrica Scandinavica, 49, 191–197.Google Scholar
Flor-Henry, P. (1976) Lateralized temporal-limbic dysfunction and psychopathology. Annals of the New York Academy of Sciences, 280, 777–795.Google Scholar
Gruzelier, J. & Flor-Henry, P. (1979) Hemispheric Asymmetries of Function in Psychopathology. Amsterdam: Biomedical Press.Google Scholar
Gur, R. C., Gur, R. E., Obrist, W. D. et al (1982) Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science, 213, 659–661.Google Scholar
Gur, R. E., Skolnick, B. E., Gur, R. C., et al (1984) Brain function in psychiatric disorders. II. Regional cerebral blood flow in medicated unipolar depressives. Archives of General Psychiatry, 41, 695–699.Google Scholar
Gustafson, L., Risberg, J. & Silfverskiöld, P. (1981) Regional cerebral blood flow in organic dementia and affective disorders. In Electroneurophysiology and Psychopathology. Advances in Biological Psychiatry (vol. 6). (eds C. Perris, D. Kemali & L. Vacca), pp. 109–116. Basel: Karger.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Johanson, M., Risberg, J. Silfverskiöld, P., et al (1979) Regional cerebral blood flow related to acute memory disturbance following electroconvulsive therapy on depression. Acta Neurologica Scandinavica, 60 (suppl. 72), 534–535.Google Scholar
Kanno, I. & Lassen, N. (1979) Two methods for calculation of regional cerebral blood flow from emission computed tomography of inert gas concentration. Journal of Computer Assisted Tomography, 3, 71–76.CrossRefGoogle Scholar
Kupkfer, D. J., Foster, F. G., Coble, P., et al (1978) The application of the EEG sleep for the differential diagnosis of affective disorders. American Journal of Psychiatry, 135, 69–74.Google Scholar
Lassen, N. & Rommer, P. (1986) Cerebral blood flow tomography by single photon emission computerized tomography using 133Xenon in cerebrovascular disease. In Monograph on Atherosclerosis, vol. 14 (eds A. Ventura, G. Crepaldi & V. Senin), pp. 71–82. Basel: Karger.Google Scholar
Lipsey, J. R., Robinson, R. G., Pearlson, G. D., et al (1983) Mood change following bilateral hemisphere brain injury. British Journal of Psychiatry, 143, 266–273.Google Scholar
Lishman, W. A. (1968) Brain damage in relation to psychiatric disability after head injury. British Journal of Psychiatry, 144, 373–410.CrossRefGoogle Scholar
Mathew, R. J., Meyer, J. S., Francis, D. J., et al (1980) Cerebral blood flow in depression. American Journal of Psychiatry, 137, 1449–1450.Google Scholar
Mendlewicz, J., Kerkhofs, M., Hoffmann, G., et al (1984) Dexamethasone suppression test and REM sleep in patients with major depressive disorders. British Journal of Psychiatry, 45, 383–388.Google Scholar
Nie, N. H., Hull, C. H., Jenkins, J. G., et al (1975). Statistical Package for the Social Sciences (2nd edn). New York: McGraw-Hill.Google Scholar
Obrist, W. D., Thompson, H. K., Wang, H. S., et al (1975) Regional cerebral blood flow estimated by 133Xenon inhalation. Stroke, 6, 245–256.Google Scholar
Oldfield, R. C. (1971) The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia, 9, 97–113.CrossRefGoogle ScholarPubMed
Rechtschaffen, A. & Kales, A. (1968) A Manual of Standardised Terminology, Techniques and Storing System for Sleep Stages of Human Subjects. Washington, DC: USPHS Government Printing Office.Google Scholar
Risberg, J. (1980) Regional cerebral blood flow measurements by 133Xenon-inhalation: methodology and applications in neuropsychology and psychiatry. Brain and Language, 9, 9–34.Google Scholar
Rootwelt, K., Dybevold, S., Nyberg-Hansen, R., et al (1986) Measurement of cerebral blood flow with 133Xenon inhalation and dynamic single photon emission computer tomography. Normal values. Scandinavian Journal of Clinical Laboratory Investigations, 46, (suppl. 184), 97–105.Google Scholar
Sackeim, H. A., Greenberg, M. S., Weinan, A. L., et al (1982) Hemispheric asymmetry in the expression of positive and negative emotions. Archives of Neurology, 39, 210–218.Google Scholar
Silfverskiöld, P., Gustafson, L., Johanson, M., et al Regional cerebral blood flow related to the effect of electroconvulsive therapy in depression. In Biological Psychiatry Today (eds J. Obiols, C. Balluis, E. Gonzalez, et al), pp. 1178–1183. Amsterdam: Elsevier.Google Scholar
Silfverskiöld, P., & Risberg, J. (1989) Regional cerebral blood flow in depression and mania. Archives of General Psychiatry, 46, 253–259.Google Scholar
Spitzer, R. L., Endicott, J. & Robbins, E. (1975) Research Diagnostic Criteria for a Selected Group of functional Disorders (2nd edn). New York: State Psychiatric Institute.Google Scholar
Uytenhoef, P., Portelange, P., Jacquy, J., et al (1983) Regional cerebral blood flow and lateralized hemispheric dysfunction in depression. British Journal of Psychiatry, 143, 128–132.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.